Orally Administered Probiotics Decrease Aggregatibacter actinomycetemcomitans but Not Other Periodontal Pathogenic Bacteria Counts in the Oral Cavity: A Systematic Review and Meta-Analysis

Sang-Ngoen, Thanyaporn; Czumbel, László Márk; Sadaeng, Wuttapon; Mikó, Alexandra; Németh, Dávid; Mátrai, Péter; Hegyi, Péter; Tóth, Barbara; Csupor, Dezső; Kiss, István; Szabó, Andrea; Gerber, Gábor; Varga, Gábor; Kerémi, Beáta

doi:10.3389/fphar.2021.682656

Cited by 13 publications

(8 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biofilms are observed on some tooth surfaces, enamel and other parts of the oral cavity due to the adhesion, aggregation and colonization of various bacteria [ 58 , 59 ]. When the microbial community in the oral cavity is imbalanced, various oral diseases may occur, which in turn, affects the health of different parts of the body [ 60 ].…”

Section: The Site Of Action Of Probiotics and Their Corresponding Dos...mentioning

confidence: 99%

Characteristics of Probiotic Preparations and Their Applications

Wang

Chen

Xia

et al. 2022

Foods

View full text Add to dashboard Cite

The probiotics market is one of the fastest growing segments of the food industry as there is growing scientific evidence of the positive health effects of probiotics on consumers. Currently, there are various forms of probiotic products and they can be categorized according to dosage form and the site of action. To increase the effectiveness of probiotic preparations, they need to be specifically designed so they can target different sites, such as the oral, upper respiratory or gastrointestinal tracts. Here we review the characteristics of different dosage forms of probiotics and discuss methods to improve their bioavailability in detail, in the hope that this article will provide a reference for the development of probiotic products.

show abstract

Section: The Site Of Action Of Probiotics and Their Corresponding Dos...mentioning

confidence: 99%

Characteristics of Probiotic Preparations and Their Applications

Wang

Chen

Xia

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

“…One such approach is the direct application of live microorganisms that can confer a health benefit to the host, commonly referred to as probiotics 4 . While several probiotic strains have shown beneficial effects for oral health 5 – 11 , other studies assert a more limited benefit for their use 12 – 15 . Though the current opinion on oral probiotics may seem mixed, differences in strain effectiveness are often not taken into consideration.…”

Section: Introduction/state-of-the-artmentioning

confidence: 99%

Antimicrobial potential of known and novel probiotics on in vitro periodontitis biofilms

Holm

Carvalho

Delanghe

et al. 2023

npj Biofilms Microbiomes

View full text Add to dashboard Cite

Several oral diseases are characterized by a shift within the oral microbiome towards a pathogenic, dysbiotic composition. Broad-spectrum antimicrobials are often part of patient care. However, because of the rising antibiotic resistance, alternatives are increasingly desirable. Alternatively, supplying beneficial species through probiotics is increasingly showing favorable results. Unfortunately, these probiotics are rarely evaluated comparatively. In this study, the in vitro effects of three known and three novel Lactobacillus strains, together with four novel Streptococcus salivarius strains were comparatively evaluated for antagonistic effects on proximal agar growth, antimicrobial properties of probiotic supernatant and the probiotic’s effects on in vitro periodontal biofilms. Strain-specific effects were observed as differences in efficacy between genera and differences within genera. While some of the Lactobacillus candidates were able to reduce the periodontal pathobiont A. actinomycetemcomitans, the S. salivarius strains were not. However, the S. salivarius strains were more effective against periodontal pathobionts P. intermedia, P. gingivalis, and F. nucleatum. Vexingly, most of the Lactobacillus strains also negatively affected the prevalence of commensal species within the biofilms, while this was lower for S. salivarius strains. Both within lactobacilli and streptococci, some strains showed significantly more inhibition of the pathobionts, indicating the importance of proper strain selection. Additionally, some species showed reductions in non-target species, which can result in unexpected and unexplored effects on the whole microbiome.

show abstract

“…In combination with fluoride, their administration prevented or slowed the early demineralization of enamel [ 56 , 61 , 62 ]. In one study, a significant reduction in Aggregatibacter Actinomycetemcomitans , but not other periodontal pathogenic bacteria, occurred with probiotic administration in the oral cavity [ 63 ]. The science of probiotics using non-pathogenic oral bacteria, such as Streptococcus Salivarius M18 , creates strain-specific and tissue-mediated antagonism by releasing bacteriocins (salivaricins) with antibiotic action [ 64 , 65 ].…”

Section: Introductionmentioning

confidence: 99%

Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature

et al. 2022

View full text Add to dashboard Cite

The oral microbiota plays a vital role in the human microbiome and oral health. Imbalances between microbes and their hosts can lead to oral and systemic disorders such as diabetes or cardiovascular disease. The purpose of this review is to investigate the literature evidence of oral microbiota dysbiosis on oral health and discuss current knowledge and emerging mechanisms governing oral polymicrobial synergy and dysbiosis; both have enhanced our understanding of pathogenic mechanisms and aided the design of innovative therapeutic approaches as ORALBIOTICA for oral diseases such as demineralization. PubMed, Web of Science, Google Scholar, Scopus, Cochrane Library, EMBEDDED, Dentistry & Oral Sciences Source via EBSCO, APA PsycINFO, APA PsyArticles, and DRUGS@FDA were searched for publications that matched our topic from January 2017 to 22 April 2022, with an English language constraint using the following Boolean keywords: (“microbio*” and “demineralization*”) AND (“oral microbiota” and “demineralization”). Twenty-two studies were included for qualitative analysis. As seen by the studies included in this review, the balance of the microbiota is unstable and influenced by oral hygiene, the presence of orthodontic devices in the oral cavity and poor eating habits that can modify its composition and behavior in both positive and negative ways, increasing the development of demineralization, caries processes, and periodontal disease. Under conditions of dysbiosis, favored by an acidic environment, the reproduction of specific bacterial strains increases, favoring cariogenic ones such as Bifidobacterium dentium, Bifidobacterium longum, and S. mutans, than S. salivarius and A. viscosus, and increasing of Firmicutes strains to the disadvantage of Bacteroidetes. Microbial balance can be restored by using probiotics and prebiotics to manage and treat oral diseases, as evidenced by mouthwashes or dietary modifications that can influence microbiota balance and prevent or slow disease progression.

show abstract

Orally Administered Probiotics Decrease Aggregatibacter actinomycetemcomitans but Not Other Periodontal Pathogenic Bacteria Counts in the Oral Cavity: A Systematic Review and Meta-Analysis

Cited by 13 publications

References 77 publications

Characteristics of Probiotic Preparations and Their Applications

Characteristics of Probiotic Preparations and Their Applications

Antimicrobial potential of known and novel probiotics on in vitro periodontitis biofilms

Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature

Contact Info

Product

Resources

About