Oral zinc supplementation for reducing mortality in probable neonatal sepsis: A double blind randomized placebo controlled trial

Mehta, Kayur; Bhatta, Narendra; Majhi, S; Shrivastava, Manoj Kumar; Singh, Rupa

doi:10.1007/s13312-013-0120-2

Cited by 36 publications

(30 citation statements)

References 7 publications

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“…462 However, oral zinc supplementation did not alter mortality in neonates with probable sepsis. 463 In a study of pediatric patients who met the criteria for septic shock, 6 a unique whole-blood transcriptomic response was found in neonates as compared with infants, toddlers, and school-age children. Neonates manifested the largest number of uniquely regulated genes, representing both innate and adaptive immune system pathways, and showed a predominance of down-regulated transcripts representing the adaptive immune system.…”

Section: Impact Of Systems Biology Approachesmentioning

confidence: 99%

Pathophysiology of Neonatal Sepsis

Wynn¹,

Wong²

2017

Fetal and Neonatal Physiology

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Section: Impact Of Systems Biology Approachesmentioning

confidence: 99%

Pathophysiology of Neonatal Sepsis

Wynn¹,

Wong²

2017

Fetal and Neonatal Physiology

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“…It occurs in 1/1,000 full-term and 4/1,000 premature live births, and mortality rates can reach values up to 20% in some settings and among very low-birth-weight (VLBW) infants [1]–[3].…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms and Sepsis in Premature Neonates

et al. 2014

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Identifying single nucleotide polymorphisms (SNPs) in the genes involved in sepsis may help to clarify the pathophysiology of neonatal sepsis. The aim of this study was to evaluate the relationships between sepsis in pre-term neonates and genes potentially involved in the response to invasion by infectious agents. The study involved 101 pre-term neonates born between June 2008 and May 2012 with a diagnosis of microbiologically confirmed sepsis, 98 pre-term neonates with clinical sepsis and 100 randomly selected, otherwise healthy pre-term neonates born during the study period. During the study, 47 SNPs in 18 candidate genes were genotyped on Guthrie cards using an ABI PRISM 7900 HT Fast real-time and MAssARRAY for nucleic acids instruments. Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). Among the patients with bacteriologically confirmed sepsis, only genotype GG of rs2664349 (the MMP-16 gene) showed a significant association with an increased risk (p = 0.02). Genotypes GG of rs2569190 (the CD14 gene) and AT of rs4073 (the IL8 gene) were associated with a significantly increased risk of developing severe sepsis (p = 0.05 and p = 0.01). Genotype AG of rs1800629 (the LTA gene) and genotypes CC and CT of rs1341023 (the BPI gene) were associated with a significantly increased risk of developing Gram-negative sepsis (p = 0.04, p = 0.04 and p = 0.03). These results show that genetic variability seems to play a role in sepsis in pre-term neonates by influencing susceptibility to and the severity of the disease, as well as the risk of having disease due to specific pathogens.

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“…This study focuses on sepsis being one of the illnesses of newborn caused by bacteria that is found in the blood. According to [14], Neonatal sepsis is a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 4 weeks of life. Sepsis is when the immune system responds to a serious infection by attacking the body's own organs and tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Bacteria from the infection and the toxins they create can change a person's body temperature, heart rate, and blood pressure, and prevent the body's organ from working properly [11]. Neonatal Sepsis can affect people of any age and according to [14], can be classified into two sub-types depending upon whether the onset of symptoms is before 72 hours of life (early onset) or later (late onset). [10], posit that in 1992, a consensus conference held by the American College of Chest Physicians decided that a patient will be diagnosed with sepsis if they present with Systemic Inflammatory Response Syndrome (SIRS), which is readily diagnosed by the presence of at least two of: fever or hypothermia, tachycardia, tachypnea or hyperventilation, leukocytosis or leucopenia in addition to a confirmed infection.…”

Section: Introductionmentioning

confidence: 99%