“…Recommendations have ranged from medical management alone to radical surgery with adjuvant chemotherapy (4, 27, 28, 35). Combination antifungal therapy with amphotericin B and itraconazole, voriconazole, or micafungin with or without surgical intervention has been used successfully to control the infection in some cases (3, 19, 26, 28, 34, 35). Voriconazole recently has become the drug of choice for invasive aspergillosis because patients demonstrate a better tolerance for it and because of its lower toxicity compared with amphoterecin B (3); the overall response rate to antifungal chemotherapy ranges from 40% to 60% (39).…”