Oral Vaccination of Captive Small Indian Mongoose (<i>Herpestes auropunctatus</i>) against Rabies

Vos, Ad; Kretzschmar, Antje; Ortmann, Steffen; Lojkić, Ivana; Habla, C.; Müller, Thomas; Kaiser, Christian; Hundt, Boris; Schuster, Peter

doi:10.7589/2013-02-035

Cited by 30 publications

(20 citation statements)

References 12 publications

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“…The N protein as part of intracellular ribonucleoproteins (RNPs) accumulates in large inclusion bodies and is likely to be less prone to degradation, while soluble GFP may be less stable in infected cells and may be rapidly removed by host immune system. Strikingly, comparative immunofluorescence analyses revealed substantially more vaccine virus and virus infected cells in species that are more responsive to oral vaccination, thus corroborating general assumptions and field observations on differences among reservoir species in vaccine uptake efficiencies 8 www.nature.com/scientificreports www.nature.com/scientificreports/ to oral rabies vaccination [18][19][20][21][22][23] . Viral N-protein staining confirmed locally restricted areas of RABV infected cells in the peripheral layer of the t. palatina of foxes, raccoon dogs and mongooses with similar limited vertical and lateral spread of virus infection, but failed to identify even single infected cells in the other species (Fig.…”

Section: Discussionsupporting

confidence: 63%

“…To investigate species-specific differences in vaccine virus tropism, all animals received 1.0 mL SAD L16 GFP (10 8 FFU/mL) by direct oral application (d.o.A.). This rather high dose was selected because it increased the likelihood of successful immunization in all species based on experience with SAD B19 or SAD B19-derived oral rabies virus vaccines 19,20,23,28,32 .…”

Section: Methodsmentioning

confidence: 99%

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Responsiveness of various reservoir species to oral rabies vaccination correlates with differences in vaccine uptake of mucosa associated lymphoid tissues

Kamp

Freuling

Vos³

et al. 2020

Sci Rep

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Oral rabies vaccination (ORV) is highly effective in foxes and raccoon dogs, whereas for unknown reasons the efficacy of ORV in other reservoir species is less pronounced. To investigate possible variations in species-specific cell tropism and local replication of vaccine virus, different reservoir species including foxes, raccoon dogs, raccoons, mongooses, dogs and skunks were orally immunised with a highly attenuated, high-titred GFP-expressing rabies virus (RABV). Immunofluorescence and RT-qPCR screenings revealed clear differences among species suggesting host specific limitations to ORV. While for responsive species the palatine tonsils (tonsilla palatina) were identified as a main site of virus replication, less virus dissemination was observed in the tonsils of rather refractory species. While our comparison of vaccine virus tropism emphasizes the important role that the tonsilla palatina plays in eliciting an immune response to ORV, our data also indicate that other lymphoid tissues may have a more important role than originally anticipated. Overall, these data support a model in which the susceptibility to oral live RABV vaccine infection of lymphatic tissue is a major determinant in vaccination efficacy. The present results may help to direct future research for improving vaccine uptake and efficacy of oral rabies vaccines under field conditions.

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Section: Discussionsupporting

confidence: 63%

Section: Methodsmentioning

confidence: 99%

Responsiveness of various reservoir species to oral rabies vaccination correlates with differences in vaccine uptake of mucosa associated lymphoid tissues

Kamp

Freuling

Vos³

et al. 2020

Sci Rep

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“…Their successful use of diverse habitat on the Caribbean Islands resulted in mongooses being a significant public health threat where they are a rabies reservoir. These islands include Puerto Rico, Grenada, Cuba, the Dominican Republic, and most likely Haiti (Tierkel et al , Nadin‐Davis et al , Vos et al ).…”

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confidence: 99%

Estimates of small Indian mongoose densities: Implications for rabies management

et al. 2015

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The small Indian mongoose (Herpestes auropunctatus) is an invasive species and rabies reservoir in Puerto Rico. In the continental United States, terrestrial wildlife rabies is primarily managed by the National Rabies Management Program (NRMP) of the United States Department of Agriculture through oral rabies vaccination (ORV); the distribution of the vaccine baits is influenced by the population density of the target species. The NRMP uses a density index for estimating raccoon (Procyon lotor) population density to guide bait distribution. In Puerto Rico, a wildlife rabies vaccination program does not exist and vaccination of domestic animals is limited and not compulsory. To acquire information on density and other population dynamics, we compared a mongoose density index (MDI) adapted from the NRMP raccoon density index (RDI) to 3 other methods (2 types of capture-mark-recapture [CAPTURE and MARK] and spatially explicit capture-recapture [SECR]) for estimating density that incorporate modeling procedures on detection probabilities, and examined the spatial distribution of mongooses within our study plots. We used the RDI trapping protocol modified for mongooses to livetrap mongooses in El Yunque National Forest (El Yunque) and Cabo Rojo National Wildlife Refuge (Cabo Rojo) in fall of 2011 and spring of 2012 resulting in 4 trapping sessions. The MDI estimates were consistently less than those from other methods for estimating mongoose densities. The MDI detected a greater mongoose density during the wet season (0.55 mongooses/ha) than the dry season (0.34 mongooses/ha) at Cabo Rojo, consistent with all 3 other density estimation methods. Overall, the correlation coefficient between MDI and the other calculation methods was !0.68. When we examined known locations of mongooses and travel distances, we detected more mongooses in a smaller area within the study plot at Cabo Rojo than at El Yunque. The MDI provided information on the spatial distribution of mongooses, which will be needed to implement an ORV program to target mongooses in Puerto Rico. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

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“…Experimental vaccines have performed well for mongooses (Blanton et al 2006;Vos et al 2013), but none are commercially available. Mongoose-specific bait matrices for vaccine delivery are being studied to facilitate eventual implementation of vaccination through baiting.…”

Section: Management Approachmentioning

confidence: 99%

Diverse examples from managing invasive vertebrate species on inhabited islands of the United States

Engeman¹,

Avery²,

Shiels³

et al. 2017

Australasian Journal of Environmental Management

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Oral Vaccination of Captive Small Indian Mongoose (Herpestes auropunctatus) against Rabies

Cited by 30 publications

References 12 publications

Responsiveness of various reservoir species to oral rabies vaccination correlates with differences in vaccine uptake of mucosa associated lymphoid tissues

Responsiveness of various reservoir species to oral rabies vaccination correlates with differences in vaccine uptake of mucosa associated lymphoid tissues

Estimates of small Indian mongoose densities: Implications for rabies management

Diverse examples from managing invasive vertebrate species on inhabited islands of the United States

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