Oral ulceration: an unusual manifestation of Churg–Strauss syndrome

Abstract

Churg-Strauss Syndrome (CSS) is a relatively rare entity characterized by asthma, transient pulmonary infiltrates, eosinophilia and systemic vasculitis. Oral ulceration is a possible clinical manifestation of some systemic vasculitides, such as Wegener's granulomatosis (WG) or giant cell arteritis, but has never been reported with Churg-Strauss syndrome. We report the first observation of a palatine ulceration in a 15-year-old girl with Churg-Strauss syndrome.

Refractory oral ulcers in eosinophilic granulomatosis with polyangiitis

“…1 Oral ulcers are uncommon clinical manifestations in EGPA. 2,3 The present case demonstrated refractory oral ulcers with severe eosinophilic infiltrates.…”

“…Oral ulcers are uncommon clinical features in EGPA. 2,3 In the present case, we were able to clinically link the symptom to the disease due to the presence of preceding bronchial asthma, subsequent cutaneous lesions and eosinophilia. Typical histological features of EGPA are leukocytoclastic vasculitis and palisading granuloma associated with eosinophils.…”

“…1 Oral ulcers are uncommon clinical manifestations in EGPA. 2,3 The present case demonstrated refractory oral ulcers with severe eosinophilic infiltrates.A 49-year-old woman had been suffering from painful oral ulcers for several months. Physical examination revealed multiple ulcers with necrotic tissue on the palate, tongue, gingiva and floor of the mouth, which seemed to predominate on the right side (Fig.…”

“…Takuya OTSUKA, 1 Hiroaki IWATA, 1 Hideyuki KOSUMI, 1 Ken MURAMATSU, 1 Takamasa ITO, 1 Masumi TSUJIWAKI, 1 Yasuyuki FUJITA, 1 Mayumi KAMAGUCHI, 2 Yoshimasa KITAGAWA, 2 Hiroshi SHIMIZU 1…”

Facial blistering eruption in a patient with acute respiratory failure

“…Facial lesions have only rarely been reported in EGPA, and previous cases described additional manifestations at other sites [5,6]. The pathogenesis of EGPA and how tolerance to ANCA antigens is lost in ANCA-associated vasculitis (AAV) remains unclear.…”