Oral tuberculosis following successful treatment of oral malignancy

Bagga, Preeti; Dewan, Abhinav; Agarwal, Pankaj; Garg, Chanchal; Datta, Niloy Ranjan

doi:10.4103/0973-1482.106590

Cited by 3 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to WHO, around onethird of the population has a latent TB infection, and this can undergo reactivation in those with an incompetent immune system. 13 Her baseline chest radiograph revealed minimal infiltrates which were suspicious for tuberculosis, but because the priority was to start her on chemotherapy, work-up and treatment for latent tuberculosis were not pursued.…”

Section: Discussionmentioning

confidence: 99%

Cervical Tuberculosis Mimicking Tumor Persistence: A Case Report

Factor, MD,

Toral, MD, MSc,

Bravo, MD, MS

2024

Acta Med Philipp

View full text Add to dashboard Cite

Tuberculosis can coexist with malignancy in the same organ, but cancer with TB in the cervix is rare. This is a case of cervical tuberculosis diagnosed in a cervical cancer patient after concurrent chemoradiotherapy and brachytherapy. This is the case of a 38-year-old G2P2 (2002) diagnosed with squamous cell carcinoma, large cell non-keratinizing cervix, Stage IIIB. The patient underwent concurrent chemoradiotherapy and brachytherapy. One month after the last brachytherapy dose, the attending physician noted a nodularity on the anterior lip of the cervix. A cervical punch biopsy was done to rule out tumor persistence. The histopathology revealed chronic granulomatous inflammation with Langhan’s type multinucleated giant cells consistent with tuberculous infection. She was diagnosed with cervical tuberculosis, postulated to be from latent TB reactivation, and was given Anti-Koch’s medication for six months. After receiving Anti-Koch’s treatment, the cervical nodularity was no longer appreciated, and the rest of the cervix was smooth on palpation. Her Pap Test was negative for any intraepithelial lesion and was declared with no evidence of carcinoma. A possible latent TB infection should always be screened in cancer patients from high-burden areas or those with close contact treated for tuberculosis because immunosuppression during cancer treatment can cause the reactivation of tuberculous disease. Cervical tuberculosis complicating cervical malignancy is treatable with Anti-Koch’s therapy and has not been shown to affect the course of the carcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Cervical Tuberculosis Mimicking Tumor Persistence: A Case Report

Factor, MD,

Toral, MD, MSc,

Bravo, MD, MS

2024

Acta Med Philipp

View full text Add to dashboard Cite

show abstract

“…The percentage of patients with concomitant pulmonary involvement was 41, [10,16,39–53] among them identifying 1 case of simultaneous pulmonary, tonsillar and cerebral tuberculosis, [54] 1 case of simultaneous pulmonary, tonsillar and renal involvement, [55] 3 cases of pulmonary, tonsillar and larynx tuberculosis, [56–58] and 5 immunocompromised patients: 1 case of HIV infection associated with pulmonary and tonsillar tuberculosis, [59] 2 patients developing pulmonary and tonsillar tuberculosis under anti TNF alpha inhibitors treatment, [60,61] and 2 cases of epithelial squamous cell carcinoma of the tonsil [62] or tongue [63] coexisting with pulmonary and tonsillar tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

Primary tonsillar tuberculosis in a pediatric patient

Moisă¹,

Miron²,

Adam-Raileanu³

et al. 2021

Medicine

View full text Add to dashboard Cite

Rationale:Tuberculosis is an entity that usually affects the lungs, although extrapulmonary sites can also be involved. Tonsils are rarely affected, especially in the absence of pulmonary disease, primary tonsillar tuberculosis being a diagnostic challenge for the clinician.Patient concerns:We present the case of a 14-year-old female teenager, presented to our Pediatric Service with a 14-day history of dysphagia, odynophagia and left reflex otalgia associated with a 5 kg weight loss. Clinical examination revealed mild pharyngeal erythema, marked enlargement of the left tonsil infiltrating the lateral pharyngeal wall and the uvula and painful, mobile, nonadherent to deep bilateral latero-cervical adenopathy.Diagnosis:Positive interferon-gamma release assay (QuantiFERON-TB gold). Mantoux test reading was 16 mm.Interventions:During hospitalization, the patient received Clindamycin and Gentamicin for 3 days i.v., with discrete relief of symptoms and inflammatory markers. On the 4th day of hospitalization, treatment with Imipenem/Cilastin is started for 7 days in micro-perfusion, with tonsil hypertrophy decrease in size and favorable clinical evolution.Outcome:Tonsil hypertrophy decreased in size and patient had a favorable clinical evolution. At discharge, the patient was given a 6-month course of anti-tuberculous drug.Lessons:The particularity of this case is represented by the rarity of primary tuberculosis of tonsils in children, with unilateral involvement, displaying at the same time a common issue encountered in the current practice: the limitations and the difficult course of setting the diagnosis due to the involvement of relatives in the medical act.

show abstract

“…On extensive search of the literature only four cases with co-existing oral malignancy and oral TB, have been reported. [2][3][4][5] But coexisting lesions over the cheek have never been reported. Here, we present a pioneer case of hard carcinoma cheek with tuberculosis in a 50 year old male patient who was successfully managed by multimodality approach by combining anti-tubercular therapy with chemotherapy and radiotherapy.…”

Section: Introductionmentioning

confidence: 99%