Oral, transdermal and vaginal combined contraceptives induce an increase in markers of chronic inflammation and impair insulin sensitivity in young healthy normal-weight women: a randomized study

Piltonen, Terhi; Puurunen, Johanna; Hedberg, Pirjo; Ruokonen, Aimo; Mutt, Shivaprakash Jagalur; Herzig, Karl‐Heinz; Nissinen, A; Morin‐Papunen, Laure; Tapanainen, Juha S.

doi:10.1093/humrep/des225

Cited by 71 publications

(76 citation statements)

References 39 publications

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“…Consistent with our findings, in a recent study comparing the metabolic effects of different administration routes of combined contraceptives, PTX3 levels increased after either oral or transdermal contraceptive administration, concurrently with free androgen index reduction (30). In this regard, although no data are available on the effect of androgens on PTX3 production, several studies have shown that androgens possess immune-modulating properties and, in particular, can suppress the activity of pro-inflammatory cytokines, while enhancing the activity of anti-inflammatory factors (31,32,33).…”

Section: European Journal Of Endocrinologysupporting

confidence: 92%

Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polycystic ovary syndrome

Tosi

Sarra

Bonin

et al. 2014

European Journal of Endocrinology

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Objective: Pentraxin-3 (PTX3), like C-reactive protein (CRP), is an acute-phase protein that belongs to the pentraxin superfamily. Moreover, it is expressed in the cumulus oophorus and appears to be involved in female fertility. The aim of the present study was to assess whether PTX3 levels are altered in polycystic ovary syndrome (PCOS) women and whether they show any relationship with the main features of these subjects. Design: A cross-sectional study was conducted at the outpatient clinic of an academic centre. Methods: A total of 66 women affected with PCOS and 51 healthy controls were studied. Plasma PTX3 and serum CRP were measured by ELISA. Androgens were measured by liquid chromatography-mass spectrometry and free testosterone was measured by equilibrium dialysis. In PCOS women, insulin sensitivity was assessed by the glucose clamp technique. Results: Adjusting for age and BMI, plasma PTX3 was reduced in PCOS women (PZ0.036), in contrast with serum CRP, which was increased (PZ0.004). In multiple regression analysis, serum androgens and other endocrine and ovarian features of PCOS were predictors of PTX3 levels, whereas body fat was the main independent predictor of CRP concentrations. Conclusions: Plasma PTX3 levels were reduced in PCOS women and independently associated with hyperandrogenism and other endocrine and ovarian features of PCOS.

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Section: European Journal Of Endocrinologysupporting

confidence: 92%

Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polycystic ovary syndrome

Tosi

Sarra

Bonin

et al. 2014

European Journal of Endocrinology

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“…The study population consisted of 298 women with PCOS and 194 healthy women who participated in six Nordic PCOS studies performed in two countries: four studies in Finland and two in Sweden . PCOS was diagnosed according to the Rotterdam criteria .…”

Section: Methodsmentioning

confidence: 99%

Bone markers in polycystic ovary syndrome: A multicentre study

Lingaiah

Morin‐Papunen

Piltonen

et al. 2017

Clinical Endocrinology

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“…Another similar study in 1992 revealed the same result [13]. A study in Finland [14] found that consumers of COC pills had significantly higher mean serum glucose levels compared to their baseline values, with an increased risk of developing glucose metabolism abnormalities. In the present study, it is important to note that even though the FBS level has increased, only small number of COC pills user demonstrated abnormally high glucose level.…”

Section: Physical and Biochemical Measurementsmentioning

confidence: 69%

Pattern of Fasting Blood Sugar, Blood Pressure and Body Mass Index among Combined Oral Contraceptive (COC) Pills Users in Chencha, Southern Ethiopia: a cross-sectional study

Kofole¹,

Haile²,

Solomon³

et al. 2019

Preprint

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Background: The use of contraceptives has become prevalent among women in Ethiopia. Oral contraceptive use has been suggested to trigger changes in glucose metabolism, energy expenditure, blood pressure, and body weight, among the various populations and ethnic groups. Objective: To elucidate the pattern of fasting blood sugar (FBS), blood pressure and body mass index (BMI) among combined oral contraceptive (COC) pills users, taking into account other confounding factors including socioeconomic conditions and physical activity status. Methods: An institution based cross-sectional study design was employed. A total of 110 healthy women using pills were recruited as cases. Another 110 healthy women not using any hormonal contraceptives were recruited as matched controls. A study was conducted between October 2018 and January 2019. Fasting Capillary blood sample was collected from the study participants for the estimation of the FBS level. Systolic and diastolic blood pressures were measured and means arterial blood pressure was calculated for each participant. Body weight and height were measured to compute body mass index. Data obtained was entered and analyzed using IBM SPSS version 23 software packages. Results: FBS level in users was significantly increased compared to controls (88.55 ± 7.89 vs. 86.00 ± 9.85 in users and controls respectively, P = 0.025). There was a significant difference in mean arterial blood pressure of users compared to controls (88.2 ± 8.48 vs. 86.0 ± 6.74 respectively, P=0.04). The mean weight and body mass index of users were significantly increased (P = 0.03 and P = 0.003, respectively). Changes in mean fasting blood sugar level and mean weight of users were independent (P = 0.27 and P = 0.46) to the duration of use (3-12, 13-24 and ≥ 25 months). On the other hand, changes in mean body mass index and mean arterial blood pressure of users were dependent of the duration of use (P = 0.03 and P = 0.000 respectively). Conclusions: Overall, oral contraceptive pills use appears to cause a 2.9% increase in fasting blood glucose level, a 2.5% increase in mean arterial blood pressure and a 3.9% increase in body mass index among the users.

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Oral, transdermal and vaginal combined contraceptives induce an increase in markers of chronic inflammation and impair insulin sensitivity in young healthy normal-weight women: a randomized study

Abstract: NCT01087879.

Cited by 71 publications

References 39 publications

Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polycystic ovary syndrome

Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polycystic ovary syndrome

Bone markers in polycystic ovary syndrome: A multicentre study

Pattern of Fasting Blood Sugar, Blood Pressure and Body Mass Index among Combined Oral Contraceptive (COC) Pills Users in Chencha, Southern Ethiopia: a cross-sectional study

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