Oral Toxicity of Bismuth in Rat: Single and 28‐Day Repeated Administration Studies

Abstract

The consumption and production of bismuth are increasing, however there is very little information about the direct toxic effect of bismuth. The present study aimed to characterize the potential toxic effects of bismuth through oral administration and observation for fourteen days following single dose of 0 and 2,000 mg/kg (acute oral toxicity study), and repeated oral administration for twenty-eight days at dose levels of 0, 40, 200, and 1,000 mg/kg daily (28-d repeated oral dose toxicity study) to male and female Crj:CD (SD) IGS rats (SPF). We found no deaths and no abnormalities in clinical signs, body weights, and necropsy findings for any of the animals in the acute oral toxicity study and no changes attributable to bismuth in either males or females in the dose group up to 1,000 mg/kg of the 28-d repeated-dose toxicity study. Therefore, we determined that the lethal dose with a 50% mortality rate (LD50) is greater than 2,000 mg/kg and the no-observed-adverse-effect level (NOAEL) of bismuth is 1,000 mg/kg in both sexes. We conclude that the adverse toxic effects of bismuth as a simple metal substance are low compared to lead toxicity under the conditions tested in our studies.

Laboratory evaluation of the physicochemical properties of a new root canal sealer based on Copaifera multijuga oil‐resin

“…1999a). It also gave good radiopacity to Biosealer, better than barium sulphate, with the advantage of having a lower risk of toxicity, because bismuth is considered a less toxic heavy metal (Sano et al. 2005).…”

Aggregation Induced Phosphorescence in the Main Group

“…[38] Thus achieving phosphorescence by incorporation of this element into molecules is of great interest for various applications, such as in OLEDs and in bioimaging. [38] Thus achieving phosphorescence by incorporation of this element into molecules is of great interest for various applications, such as in OLEDs and in bioimaging.…”

Genotoxicity Studies of Heavy Metals: Lead, Bismuth, Indium, Silver and Antimony

“…Thus, we conducted bacterial mutation tests and chromosomal aberration tests in cultured mammalian cells for these metals as well as lead for a positive control metal. In our previous studies, animal experiments using rats were performed to examine the oral toxicity of bismuth and indium 2,3) . These two metals did not show toxicity in both acute oral toxicity studies and 28-day repeated oral dose toxicity studies.…”