Oral tongue cancer in patients less than 45 years old: institutional experience and comparison with older patients.

Siegelmann‐Danieli, Nava; Hanlon, Alexandra; Ridge, John A.; Padmore, Ruth; Fein, Douglas A.; Langer, Corey J.

doi:10.1200/jco.1998.16.2.745

Cited by 83 publications

(79 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the cases presented late i.e., stage 3 or stage 4 involving adjacent structures. They are definitely higher than those presented in earlier series [8]. More advanced stage lesions are seen with buccal mucosal cancer than tongue cancer.…”

Section: Discussioncontrasting

confidence: 56%

Carcinoma buccal cavity: Late presentation and salvage, experience from a North Indian center

Tripathy

Yaseen²,

Bariar³

et al. 2010

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Carcinoma buccal cavity, the most common oral cavity cancer was seen in our set up in more than 50% cases. Forty patients of carcinoma buccal cavity were studied at JN Medical College, Aligarh Muslim University, and Aligarh over a period of last 5 years (2003)(2004)(2005)(2006)(2007)(2008). Mean age at presentation 36.5 years (30-55) years. Male: Female, 27:13.Most common association was with smoking and chewing tobacco and pan over a mean long period of 15 years (8-22 years). Most common location was lateral wall of buccal cavity over cheek area related to their typical chewing habit of keeping the tobacco over that area over a prolonged period. Most of them, more than 90% (36 cases) presented late involving both mucosa and skin and in 25% cases also involving the alveolus and mandible. Wide excision and modified radical neck dissection with or without mandibulectomy (marginal, partial or hemimandibulectomy) done in all cases. Reconstruction was done by pedicled pectoralis major (PM) and deltopectoral (DP), the workhorse flaps for head and neck reconstruction for mucosal lining and skin cover respectively in 25 cases. Five cases needed only lining done by PM flap. Ten cases were salvaged by pedicled forehead flap for both lining and cover. All the cases healed properly with acceptable results and good functional recovery. Two cases reported recurrence treated with postoperative radiotherapy. Poor socioeconomic status, smoking and chewing habit, poor oral hygiene, malnutrition and moreover lack of awareness led to late presentation. However, an attempt was made for salvage at our center.

show abstract

Section: Discussioncontrasting

confidence: 56%

Carcinoma buccal cavity: Late presentation and salvage, experience from a North Indian center

Tripathy

Yaseen²,

Bariar³

et al. 2010

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…En nuestro trabajo consideramos la edad de 45 años como punto de corte para la categorizar la edad en dos grupos, por que considerar una edad menor disminuiría el porcentaje de pacientes correspondiente al grupo con edades menores. Nuestros resultados muestran que la incidencia estimada de la recurrencia aunque es mayor en el grupo de pacientes con edades menores o iguales que 45 años, la diferencia con el grupo de mayores que 45 años no es significativa, resultado similar al reportado en los trabajos de N Siegelmann-Danieli y DM Hyam (3,4), quienes estudian si el hecho de ser joven incorpora un peor pronóstico a los pacientes con cáncer de lengua.…”

Section: Discussionunclassified

“…Reportan 38% de recurrencia, siendo la recurrencia local mayor comparada con la recurrencia regional (3,4).…”

Section: Introductionunclassified

lisis de la recurrencia de cáncer de lengua considerando la presencia de eventos competitivos.

Quispe¹,

Vega²

2012

Rev Med Hered

View full text Add to dashboard Cite

RESUMENObjetivo: Estimar la probabilidad de recurrencia en pacientes con cáncer de lengua según la edad, el estado ganglionar patológico y el tipo de tratamiento de los pacientes considerando la muerte antes de la recurrencia como evento competitivo. Material y métodos: Serie de casos retrospectiva de 290 pacientes con cáncer de lengua, con tratamiento en el INEN, entre los años 1977 y 2000. Se excluyeron del estudio 29 pacientes tratados solo con radioterapia. De los 261 pacientes, 31 solo tuvieron tratamiento del tumor primario. Resultados: La recurrencia fue 36,8%, la recurrencia local fue la más frecuente. La incidencia acumulada de la recurrencia a los 5 años, con el método de Kaplan Meier, se estimó en 44,7%, y según el análisis de riesgos competitivos en 42,4%. En el análisis univariado considerando riesgos competitivos, las incidencias acumuladas fueron: 56,8 y 38,9% en pacientes menores o iguales que 45 y mayores que 45 años respectivamente (p = 0,1556), 29,4% y 50,5% en pacientes con ganglios patológicos negativos y positivos, respectivamente (p = 0,0002), y 37,5% en pacientes con cirugía, y 47,4% con radioterapia (p = 0,03). En el análisis multivariado, con regresión de riesgos competitivos, no se encontró diferencia entre los tipos de tratamiento sobre la recurrencia (RR = 1,146, p = 0,620). Conclusiones: La pequeña diferencia entre los resultados del método Kaplan Meier y el que toma en cuenta eventos competitivos se debe a la baja tasa del evento competitivo, más aún por que se trata de muerte no relacionada con la enfermedad. La tasa de recurrencia fue similar al reportado en la literatura. Sólo se encontró diferencia significativa en la tasa de recurrencia en el grupo con compromiso ganglionar positivo. Aunque la comparación con los métodos estándar, Kaplan Meier y Regresión de Cox, muestra resultados similares se deben tener en cuenta los eventos competitivos. (Rev Med Hered 2008;19: 145-151).PALABRAS CLAVE: Riesgos competitivos, cáncer, lengua, recurrencia. SUMMARY Objective:To estimate the probability of recurrence of tongue cancer, according age, stage pathological of lymph node and treatment type, considering death before recurrence as competing event. Materials and methods: Retrospective cases series study of 290 patients with tongue cancer, who were treated at INEN between 1977 and 2000. Twenty-nine patients who were treated only with radiotherapy were excluded. Of the remaining 261 patients, 31 were treated only at the primary tumor site. Results: Recurrence was 36.8%, local recurrence was most frequent. Five year cumulative incidence of recurrence,

show abstract

“…7,15,22 Trabalhos de Siegelman-Danieli et al (1998) não encontram diferenças na sobrevida do paciente com câncer de língua com respeito à idade, mas reportam uma tendência de pior sobrevida nos pacientes sem historia de uso de álcool e tabaco. 11 Ao contrário de muitos relatos na literatura, Jones et al (1998) com casuística de 2.647 pacientes demonstram maior taxa de sobrevida em pacientes jovens. 25 A taxa de sobrevida de 5 anos em pacientes com CCE de cabeça e pescoço da terceira a sétima décadas de vida chega a 54%, e entre a oitava a décima décadas 44%; tal diferença foi significativa estatisticamente.…”

Section: Prognóstico (Comportamento Agressivo Prognóstico Sobrevida)unclassified

Carcinoma de células escamosas da cavidade oral em pacientes jovens e sua crescente incidência: revisão de literatura

Venturi¹,

Pamplona

Cardoso

2004

Rev. Bras. Otorrinolaringol.

View full text Add to dashboard Cite

A proposta deste estudo é rever o carcinoma de células escamosas oral na população jovem. A literatura mostra um comportamento diferente neste tipo de doença, que parece ser mais agressivo. Existe uma forte relação entre alguns hábitos (tabaco e consumo de álcool) e o desenvolvimento do carcinoma de células escamosas (CCE) oral, mas nestes casos os pacientes normalmente não relatam hábitos considerados de risco. Existe um pequeno número de relatos de casos de CCE oral em pacientes com menos de 40 anos de idade, então é difícil de provar o aumento da incidência do CCE da cavidade oral como dito na literatura. Outros estudos são necessários para entendermos melhor esta entidade. A identificação das características desta população jovem se faz necessária, pois pode refletir problemas no controle do câncer e pode possibilitar o desenvolvimento de um programa de prevenção primária para o CCE oral em pacientes jovens.

show abstract

Oral tongue cancer in patients less than 45 years old: institutional experience and comparison with older patients.

Abstract: Prognosis of oral tongue SCC was not affected by age at diagnosis. CFS rates tended to be worse in cases not related to prior tobacco or alcohol exposure. Multiple smoking-related cancers occurred only in older patients.

Cited by 83 publications

References 13 publications

Carcinoma buccal cavity: Late presentation and salvage, experience from a North Indian center

Carcinoma buccal cavity: Late presentation and salvage, experience from a North Indian center

lisis de la recurrencia de cáncer de lengua considerando la presencia de eventos competitivos.

Carcinoma de células escamosas da cavidade oral em pacientes jovens e sua crescente incidência: revisão de literatura

Contact Info

Product

Resources

About