Oral Therapy With Amphotericin B of Fungal Infections in Surgical Oral Therapy With Amphotericin B of Fungal Infections in Surgical

Tsunoda, Takahiko; Tanimura, Hiroshi; Aoki, Yozo; Yamaue, Hiroki; Itō, Makoto; Ochiai, Minoru

doi:10.3919/ringe1963.51.677

Cited by 1 publication

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“…Candida glabrata is resistant to many antifungal agents, with fluconazole, flucytosine, or amphotericin B, or a combination of these agents being used. 7,8 In our patient, intravenous MCZ 400-800 mg/ day and oral AMPH 2400 mg/day were effective.…”

Section: Discussionmentioning

confidence: 56%

Fulminant hepatitis complicated by small intestine infection and massive hemorrhage

Tamura¹,

Yamashita²,

Kusano³

et al. 1998

Journal of Gastroenterology

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A 34-year-old man diagnosed with fulminant hepatitis, caused by hepatitis B virus, and acute renal failure was referred to our hospital. After admission to the intensive care unit, the liver and renal failure were ameliorated. Melena requiring transfusion occurred during the course of his illness. Endoscopic examination demonstrated pseudomembranes, erosions, ulcers, and hemorrhage in the duodenum, the upper jejunum, and the terminal ileum, suggesting widespread lesions throughout the small intestine. Pseudomonas putida, Xanthomonas maltophilia, and Candida glabrata were cultured from ileal fluid. Candida glabrata was also detected in sputum, feces, and on an intravenous catheter tip. The patient was treated with amphotericin B and miconazole. The melena was ameliorated, but inflammation of the small intestine persisted. Although we had difficulty in treating the enteritis, the patient survived, and 1 year later colonoscopic examination demonstrated no abnormalities. The small intestine is a difficult site to examine, but endoscopic examination of this site is important when massive hemorrhage develops.

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Section: Discussionmentioning

confidence: 56%