Oral Terbinafine and Itraconazole Treatments against Dermatophytes Appear Not to Favor the Establishment of &lt;b&gt;&lt;i&gt;Fusarium&lt;/i&gt;&lt;/b&gt; spp. in Nail

Verrier, Julie; Bontems, Olympia; Baudraz‐Rosselet, F.; Monod, Michel

doi:10.1159/000357764

Cited by 15 publications

(15 citation statements)

References 28 publications

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“…Frequencies vary between 1% and 16% [25,26]. Appropriate treatment is recommended because of the risk of dissemination from a local nail lesion upon increased immunosuppression [27]. The infections are clinically indistinguishable from onychomycosis by dermatophytes, and present as distal subungual, proximal subungual and total dystrophic infections [25,26].…”

Section: Onychomycosismentioning

confidence: 99%

Current antifungal treatment of fusariosis

Al‐Hatmi

Bonifáz

Ranque

et al. 2018

International Journal of Antimicrobial Agents

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Fungi of the genus Fusarium are well known as major plant pathogens and soil inhabitants, but also cause a broad spectrum of human infections. Fusariosis is the second most common mould infection after aspergillosis, and keratitis is the most encountered implantation infection in immunocompetent individuals. Natamycin is active against Fusarium species both in vitro and in vivo, and is used along with voriconazole as the mainstay of treatment for Fusarium keratitis. Onychomycosis is treated with terbinafine, voriconazole and sometimes itraconazole. Cure is possible despite high in vitro minimum inhibitory concentrations (MICs). Recently, disseminated infections have increased dramatically, mainly affecting severely immunocompromised patients. The remarkable intrinsic resistance of Fusarium species to most antifungal agents results in high mortality rates in this patient population. Recovery of neutropenia is essential for patient survival and treatment should include voriconazole or amphotericin B as first-line and posaconazole as salvage therapy.

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Section: Onychomycosismentioning

confidence: 99%

Current antifungal treatment of fusariosis

Al‐Hatmi

Bonifáz

Ranque

et al. 2018

International Journal of Antimicrobial Agents

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“…Onychomycosis is difficult to treat, requiring generally, prolonged, systemic oral treatment with anti‐fungal agents due to lack of effective therapeutic topical preparations . The necessity of management by orally administered systemic drugs and prolonged periods of treatment may result in significant adverse effects . This may lead to problems of compliance, followed by low rates of therapeutic success and recurrences of infection.…”

Section: Introductionmentioning

confidence: 99%

Onychomycosis in Israel: epidemiological aspects

Segal

Shemer

Hochberg

et al. 2015

Mycoses

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Onychomycosis is a fungal infection treated orally for prolonged periods of treatment, caused primarily by Dermatophytes, Candida species and non-dermatophyte moulds (NDMs). The prevalence of specific aetiology may differ in dependence of environmental, geographic and demographic factors, and may affect management of the infection. The objective of this survey was to analyse epidemiologic parameters of onychomycosis in Israel. Data of a cohort of 27,093 patients were collected from six centres during a 2- and 10-year period. The diagnosis was based on microscopy of KOH/calcofluor mounts of nail scrapings and culture isolation. A positive result indicates isolation of a fungus in culture. Data were analysed for each centre and expressed as range for the whole cohort, using the spss v18 software. Analysis included three epidemiologic parameters: fungal aetiology in toe- and fingernails; association with gender; association with age group. Dermatophytes were the major causative agents and Trichophyton rubrum the most frequent isolate. Candida species were more frequent in women fingernails; frequency increased with age and C. parapsilosis the most frequent species. NDMs were isolated at low rate and Aspergillus terreus was the most frequent isolate. This is a first large cohort of onychomycosis patients from Israel analysed by defined epidemiological parameters.

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“…A nested PCR assay is the modification of a conventional PCR approach in which the first amplification is followed by another amplification of a smaller region inside the initial amplified fragment [30]. The nested PCR consists of primary and secondary amplification to increase the specificity and sensitivity of a PCR [56] in which the primary PCR product is used as a template for secondary PCR to avoid primer dimer artefacts. Thus, it eliminates false‐positive and false‐negative results as well as discriminates between the specific and nonspecific DNA bands or, in other words, nested PCR tends to reduce the nonspecific binding in products due to the amplification of unexpected primer binding sites.…”

Section: Nested Pcrmentioning

confidence: 99%

Recent advances in the diagnosis of dermatophytosis

et al. 2020

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Dermatophytosis is a disease of global significance caused by pathogenic keratinolytic fungi called dermatophytes in both animals and humans. The recent taxonomy of dermatophytes classifies them into six pathogenic genera, namely Microsporum, Trichophyton, Epidermophyton, Nannizzia, Lophophyton and Arthroderma. It is because of the delayed diagnostic nature and low accuracy of dermatophyte detection by conventional methods that paved the path for the evolution of molecular diagnostic techniques, which provide the accurate and rapid diagnosis of dermatophytosis for an appropriate, timely antifungal therapy that prevents the nonspecific over‐the‐counter self‐medication. This review focuses on the importance of rapid and accurate diagnosis of dermatophytosis, limitations of conventional methods, selection of targets in diagnosis, and factors affecting sensitivity and specificity of various molecular diagnostic technologies in the diagnosis of dermatophytosis. Generally, all the molecular techniques have a significant edge over the conventional methods of culture and microscopy in the dermatophytosis diagnosis. However, in mycology laboratory, the suitability of any molecular diagnostic technique in the diagnosis of dermatophytosis is driven by the requirement of time, economy, complexity, the range of species spectrum detected and the scale of diagnostic output required. Thus, various choices involved in the pursuit of a diagnosis of dermatophytosis are determined by the available conditions and the facilities in the laboratory.

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Oral Terbinafine and Itraconazole Treatments against Dermatophytes Appear Not to Favor the Establishment of <b><i>Fusarium</i></b> spp. in Nail

Cited by 15 publications

References 28 publications

Current antifungal treatment of fusariosis

Current antifungal treatment of fusariosis

Onychomycosis in Israel: epidemiological aspects

Recent advances in the diagnosis of dermatophytosis

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