Oral Taurine Supplementation Prevents the Development of Ethanol-Induced Hypertension in Rats.

Harada, Hisashi; Kitazaki, Kazuhisa; Tsujino, Takeshi; Watari, Yasuhiro; Iwata, Sachiyo; Nonaka, Hidemi; Hayashi, Takeshi; Takeshita, Tatsuya; Morimoto, Kanehisa; Yokoyama, Mitsuhiro

doi:10.1291/hypres.23.277

Cited by 31 publications

(9 citation statements)

References 26 publications

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“…Puddey et al 83 reported a BP elevation of B10 mm Hg and decreases in the level of phospholipids and the ratio of unsaturated/saturated fatty acids in the aorta and kidney after the chronic administration of alcohol to rats. Harada et al 84 also observed increases in the BP and platelet-free calcium concentration with ethanol consumption (15%) in Wister Kyoto rats.…”

Section: Experimental Studiesmentioning

confidence: 88%

Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

Kawano

2010

Hypertens Res

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Alcohol has complex effects on the cardiovascular system. The purpose of this article is to review physio-pathological effects of alcohol on cardiovascular and related systems and to describe its role in hypertension and cardiovascular disease. The relationship between alcohol and hypertension is well known, and a reduction in the alcohol intake is widely recommended in the management of hypertension. Moreover, alcohol has both pressor and depressor actions. The latter actions are clear in Oriental subjects, especially in those who show alcohol flush because of the genetic variation in aldehyde dehydrogenase activity. Repeated alcohol intake in the evening causes an elevation in daytime and a reduction in nighttime blood pressure (BP), with little change in the average 24-h BP in Japanese men. Thus, the hypertensive effect of alcohol seems to be overestimated by the measurement of casual BP during the day. Heavy alcohol intake seems to increase the risk of several cardiovascular diseases, such as hemorrhagic stroke, arrhythmia and heart failure. On the other hand, alcohol may act to prevent atherosclerosis and to decrease the risk of ischemic heart disease, mainly by increasing HDL cholesterol and inhibiting thrombus formation. A J-or U-shaped relationship has been observed between the level of alcohol intake and risk of cardiovascular mortality and total mortality. It is reasonable to reduce the alcohol intake to less than 30 ml per day for men and 15 ml per day for women in the management of hypertension. As a small amount of alcohol seems to be beneficial, abstinence from alcohol is not recommended to prevent cardiovascular disease. INTRODUCTIONAlcohol has complex effects on the cardiovascular system. The relationship between alcohol and hypertension is well known, and a restriction of alcohol intake is widely recommended as a part of lifestyle modifications in the management of hypertension. 1-6 Alcohol has both pressor and depressor actions, however, and the genetic susceptibility regarding alcohol metabolism influences the cardiovascular effect of alcohol. 3,7 The effect of alcohol on blood pressure (BP) is also modified by several factors, such as the level of consumption, time period after the last drink and overall drinking behavior.Alcohol consumption is associated with several cardiovascular diseases, such as brain hemorrhage, heart failure and arrhythmia, as well as with other disorders. 3,[8][9][10][11] Heavy drinking and alcoholism not only lead to medical problems but are also serious social concerns. However, alcohol also seems to have beneficial effects, including the prevention of ischemic heart disease. It has been shown that cardiovascular and all-cause mortality is lower in light drinkers compared with nondrinkers. 3,[8][9][10][11][12] The purpose of this article is to review physio-pathological effects of alcohol on cardiovascular and related systems and to describe its role

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Section: Experimental Studiesmentioning

confidence: 88%

Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

Kawano

2010

Hypertens Res

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“…It is known as a conditionally essential amino acid, which is present in the brain, heart, liver, neutrophils, retina and kidneys of mammals in high concentrations [2][3][4]. It acts as an antioxidant, xenobiotic conjugant, osmoregulator, intracellular calcium flux regulator, bile acid conjugator, neuromodulator, cell membrane stabilizer and plays an important role in cell proliferation and viability [3][4][5]. Taurine is known to have regulatory activities in gastrointestinal tract including…”

Section: Editorialmentioning

confidence: 99%

Obesity and Taurine

Sattari¹,

Mashayekhi²

2015

AOWMC

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“…The antihypertensive effects of taurine have been demonstrated in several experimental models (Fujita and Sato 1984 ;Harada et al 2000 ;Nara et al 1978 ) . Studies in vitro showed that taurine relaxed pre-constricted rabbit ear artery (Franconi et al 1982 ) , rat aorta (Ristori and Verdetti 1991 ) , and rat mesenteric artery (Li et al 1996 ) .…”

Section: Discussionmentioning

confidence: 99%

Taurine Regulation of Blood Pressure and Vasoactivity

Idrissi

Okeke

Yan

et al. 2013

Advances in Experimental Medicine and Biology

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Taurine plays an important role in the modulation of cardiovascular function by acting not only within the brain but also within peripheral tissues. We found that IV injection of taurine to male rats caused hypotension and tachycardia. A single injection of taurine significantly lowered the systolic, diastolic, and mean arterial blood pressure in freely moving Long-Evans control rats. We further confirm the vasoactive properties of taurine using isolated aortic ring preparations. Mechanical responses of circular aortic rings to pharmacological agents were measured by an isometric force transducer and amplifier. We found that bath application of taurine to the aortic rings caused vasodilation which was blocked by picrotoxin. Interestingly, picrotoxin alone induced a constriction of the aortic ring in the absence of exogenously added taurine, suggesting a tonic activation of GABA(A)receptors by circulating either taurine or GABA. Additionally, we found that the endothelial cells express high levels of taurine transporters and GABA(A)receptors. We have previously shown that taurine activates GABA(A)receptors and thus we suggest that the functional implication of GABA(A)receptor activation is the relaxation of the arterial muscularis, vasodilation, and a decrease in blood pressure. Interestingly however, the effects of acute taurine injection were very different than chronic supplementation of taurine. When rats were supplemented taurine (0.05%, 4 weeks) in their drinking water, taurine has significant hypertensive properties. The increase in blood pressure was observed however only in females; males supplemented with taurine did not show an increase in systolic, diastolic, or mean arterial pressure. In both genders however, taurine supplementation caused a significant tachycardia. Thus, we suggest that acute administration of taurine may be beneficial to lowering blood pressure. However, our data indicate that supplementation of taurine to females caused a significant increase in blood pressure. The effect of taurine supplementation on hypertensive rats remains to be seen.

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Oral Taurine Supplementation Prevents the Development of Ethanol-Induced Hypertension in Rats.

Cited by 31 publications

References 26 publications

Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

Obesity and Taurine

Taurine Regulation of Blood Pressure and Vasoactivity

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