Oral Sustained Release Tablets: An Overview with a special emphasis on Matrix Tablet

Abstract

Among the various routes of drug delivery oral route is most preferred route. But conventional dosage form offers few limitations which could be resolved by modifying the existing dosage form. Sustained and controlled drug delivery system helps in maintaince of constant plasma drug concentration and retards the release rate of drug thereby extending the duration of action. There are various formulation strategies for sustained release tablets among which matrix tablet serves as an important tool. Hence the problem like poor patient compliance, multiple dosing, see-saw fluctuations can be easily minimized. Matrix tablets can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers. The rate of drug release from the matrix is primarily governed by rate and extent of water penetration, swelling of polymer, dissolution and diffusion of drug. Thus, sustained release matrix tablet can offer better patient compliance and could be quite helpful in treatment of chronic diseases. The present article concentrates on oral sustained release tablets with a special emphasis on matrix tablet.

Application of Eudragit RS 30D as a Potential Drug Release Retardant of Acetaminophen and Caffeine for Prolonged Duration of Comfort

“…Modified oral drug delivery systems are considered as a new approach towards the development of drugs [1]. Physicochemical parameters affecting the performance of a drug are being studied extensively; pharmaceutical companies are focusing on the modification and development of available drugs in the market such that they will have better safety and efficacy that will lead to increased patient compliance due to low dosing and improved efficacy [2].…”

Evaluation Profile In Vitro Release Gastroretentive High Density Tablet Theophylline Using Sodium Alginate and PVP

“…The sustained-release formulation is expected to produce a more uniform blood concentration of the drug, with a peak level that does not fluctuate. Slow-release dosage forms can guarantee patient satisfaction, especially if the patient has difficulty taking the drug repeatedly during an acute asthma attack [11] A polymer is needed to control the drug release system [12], a hydrophilic polymer is widely used in the formulation of oral sustained release dosage forms [13].…”

Formulation and evaluation of sustained release diclofenac sodium matrix tablets produced using <i>Brachystegia eurycoma </i>gum

“…The polymer may undergo a relaxation process due to the stress of the penetrated solvent, so that the polymer chains become more flexible and the matrix swells. This allows the embedded drug to diffuse quicker out of the matrix [14]. On the other hand, it would take longer time for drug to diffuse out of the matrix since matrix swelling lengthens the diffusion path.…”

“…Polymer dissolution is another important mechanism that can modulate the drug delivery rate for dissolvable polymer matrix. While either swelling or dissolution can be the major factor for a specific type of polymers, in most cases drug release kinetics is a result of a combination of these two mechanisms [7,14]. The main polymers used in hydrophilic matrices are hydroxypropyl methyl cellulose (HPMC) and hydroxypropyl cellulose (HPC), xanthan gum, carbopol and alginates [15,16].…”