Oral supplementation with lactic acid-producing bacteria during intake of clindamycin

Abstract

OBJECTIVE: To study the effect of administration of clindamycin with or without supplementation of the intestinal microflora with Bifidobacterium bifidum and Lactobacillus acidophilus. METHODS: Twenty-three healthy subjects received clindamycin by mouth for 7 days. Eleven of the subjects also received capsules containing lyophilized L. acidophilus and B. bifidum for 14 days. The other 12 subjects received placebo. RESULTS: There was a marked decrease in total numbers of anaerobic bacteria during the administration of clindamycin. In the lactic acid bacteria-supplemented group, a tendency towards delayed reduction and earlier increase in bifidobacteria was observed, and two of 11 subjects (18%) were colonized with Clostridium difficile, in comparison with five of 12 (41%) in the placebo group. The total number of microorganisms was significantly higher in the lactic acid bacteria-supplemented group than in the placebo group (p=0.02) 4 days after the end of clindamycin administration. The difference was mainly due to higher counts of Escherichia coli and enterococci. Mean levels of other enterobacteria increased less in the lactic acid bacteria-supplemented group than in the placebo group between days 0 and 14. CONCLUSIONS: The recolonization with aerobic and anaerobic microorganisms was faster in the lactic acid bacteria-supplemented group than in the placebo group. This may be of importance in preventing colonization with C. difficile.

Long-term ecological impacts of antibiotic administration on the human intestinal microbiota

“…Previous studies have shown that the administration of clindamycin often leads to major short-term ecological disturbances (Nord et al, 1997;Sullivan et al, 2003). The antibiotic is excreted in bile at high concentrations and thereby it leads to strong suppression of the anaerobic community (Nord et al, 1997;Sullivan et al, 2001).…”

“…The antibiotic is excreted in bile at high concentrations and thereby it leads to strong suppression of the anaerobic community (Nord et al, 1997;Sullivan et al, 2001). In this study, using the anaerobic Bacteroides spp.…”

Linex forte in the prevention and treatment of gastrointestinal diseases

“…Бакте-риоцины, выделяемые обоими микроорганизмами, также актив-ны в отношении Helicobacter pylori [40][41][42]. При этом в отличие от антибиотиков бактериоцины мало влияют на нормальную ки-шечную микрофлору, преимущественно угнетая колонизацию не обычными представителями микробиоты, а «чужеродными» па-тогенными микроорганизмами [21,35] и таким образом предот-вращают или устраняют нарушения микрофлоры, вызываемые антибиотиками широкого спектра действия [43][44][45].…”

“…Результаты многочисленных двойных слепых рандомизиро-ванных клинических испытаний (РКИ) подтверждают профи-лактический эффект ВB-12 и LА-5 и их комбинации в отноше-нии антибиотикоассоциированной диареи (ААД) [43][44][45][67][68][69] и диареи путешественников [70]. Даже в случае, когда не удава-лось полностью предотвратить развитие ААД, применение ком-бинации BB-12 и LА-5 приводило к значительному уменьшению ее продолжительности [71].…”

In vitro gastrointestinal resistance of Lactobacillus acidophilus La-5 and Bifidobacterium animalis Bb-12 in soy and/or milk-based synbiotic apple ice creams

“…Lactobacillus. acidophilus and B. animalis Bb-12 are two strains with demonstrated beneficial health effects such as recolonization of the intestinal microbiota (Nord et al, 1997), reduction of the duration of stomach upset (de Vrese et al, 2011), and intestinal microbiota modulation (Savard et al, 2011).…”