Oral Supplementation of Coconut Oil Attenuates Propanil-induced Oxidative Stress in the Testes of Rats

Salau, Bamidele Adewale; Otuechere, Chiagoziem A.; Avwioroko, Oghenetega J.; Tinuala, Simisola; Fayemi, Scott

doi:10.3923/ajbs.2020.70.76

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2022

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Cited by 2 publications

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“…Dose selection and duration of the study was based on the effective pharmacological data from pilot and previous studies in our laboratory (Otuechere et al, 2012(Otuechere et al, , 2019Otuechere, Avwioroko, et al, 2020). All animals were sacrificed 24 hr following the last treatment by dislocating the cervical vertebrae.…”

Section: Animals and Study Designmentioning

confidence: 99%

Pterocarpus mildbraedii(Harms) extract resolves propanil‐induced hepatic injury via repression of inflammatory stress responses in Wistar rats

Otuechere

Farombi

2020

J. Food Biochem.

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Section: Animals and Study Designmentioning

confidence: 99%

Pterocarpus mildbraedii(Harms) extract resolves propanil‐induced hepatic injury via repression of inflammatory stress responses in Wistar rats

Otuechere

Farombi

2020

J. Food Biochem.

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A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide-Induced Toxicity

Sule

Condon

Gomes

2022

Oxidative Medicine and Cellular Longevity

195

102

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Pesticides are important chemicals or biological agents that deter or kill pests. The use of pesticides has continued to increase as it is still considered the most effective method to reduce pests and increase crop growth. However, pesticides have other consequences, including potential toxicity to humans and wildlife. Pesticides have been associated with increased risk of cardiovascular disease, cancer, and birth defects. Labels on pesticides also suggest limiting exposure to these hazardous chemicals. Based on experimental evidence, various types of pesticides all seem to have a common effect, the induction of oxidative stress in different cell types and animal models. Pesticide-induced oxidative stress is caused by both reactive oxygen species (ROS) and reactive nitrogen species (RNS), which are associated with several diseases including cancer, inflammation, and cardiovascular and neurodegenerative diseases. ROS and RNS can activate at least five independent signaling pathways including mitochondrial-induced apoptosis. Limited in vitro studies also suggest that exogenous antioxidants can reduce or prevent the deleterious effects of pesticides.

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Oral Supplementation of Coconut Oil Attenuates Propanil-induced Oxidative Stress in the Testes of Rats

Cited by 2 publications

References 23 publications

Pterocarpus mildbraedii(Harms) extract resolves propanil‐induced hepatic injury via repression of inflammatory stress responses in Wistar rats

Pterocarpus mildbraedii(Harms) extract resolves propanil‐induced hepatic injury via repression of inflammatory stress responses in Wistar rats

A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide-Induced Toxicity

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