Oral submucous fibrosis

Pindborg, J. J.; Sirsat, Satyavati M.

doi:10.1016/0030-4220(66)90367-7

Cited by 473 publications

(320 citation statements)

References 11 publications

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“…Although occasionally preceded by and/or associated with vesicle formation, it is always associated with a juxta-epithelial inflammatory reaction followed by fibro elastic change of the lamina propria, with epithelial atrophy leading to stiffness of oral mucosa and causing trismus and inability to eat [6,7]. Worldwide, estimates of OSMF shows a confinement to Indians and Southeast Asians, with overall prevalence rate in India to be about 0.2-0.5 % and prevalence by gender varying from 0.2 to 2.3 % in males and 1.2-4.57 % in females [8].…”

Section: Introductionmentioning

confidence: 99%

Concomitant Association of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma and Incidence of Malignant Transformation of Oral Submucous Fibrosis in a Population of Central India: A Retrospective Study

Chourasia

Borle²,

Vastani

2015

J. Maxillofac. Oral Surg.

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Aim To evaluate the incidence of oral squamous cell carcinoma concomitant with oral sub mucous fibrosis in central India and to correlate precipitating factors associated with oral submucous fibrosis and oral squamous cell carcinoma. This paper also aims to study the incidence of oral squamous cell carcinoma arising secondary to untreated oral submucous fibrosis. Materials and Methods Two hundred and twenty five cases of oral squamous cell carcinoma and one hundred and nineteen cases of oral submucous fibrosis of various regions in oral cavity were included in the study. All the included cases were clinically and histopathologically diagnosed and retrospective data was retrieved. Result In the present study of 119 patients of oral submucous fibrosis, 97.4 % were found to have betel nut chewing habit. Incidence of malignant transformation to oral squamous cell carcinoma in patients of untreated oral submucous fibrosis was found to be 4.2 % in the present study. The incidence of oral cancer concomitant with oral submucous fibrosis was found to be 25.77 %, which is statistically significant. Conclusion From the present study, it is evident that the malignant potential of OSF is underestimated. However, considering the small sample size and the fact that the study was carried out in a small geographical area, further study with a larger sample size and longer duration of follow up on a multicentric basis may be required to reveal the actual malignant potential of the disease.

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Section: Introductionmentioning

confidence: 99%

Concomitant Association of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma and Incidence of Malignant Transformation of Oral Submucous Fibrosis in a Population of Central India: A Retrospective Study

Chourasia

Borle²,

Vastani

2015

J. Maxillofac. Oral Surg.

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“…In this study, the fibrosis is more prominently seen in superficial muscle layer using Haematoxylin and Eosin(44%) Van gieson's(46%) and Masson's trichrome(46%). Observation of observer I is in par with observer II which is Haematoxylin and Eosin (42%), Van gieson's(50%), Masson's trichrome(48%), respectively( Table 1, 2,3,5,6,8). H and E staining which is the most commonly used stain in pathology, highlighted the fibrotic changes at the deeper muscle fiber level in very few samples when compared to special stains such as Van Giesonsand Masson's trichrome which revealed fibrotic changes even in the lamina propria level (Table 1, 2,3).…”

Section: Resultsmentioning

confidence: 96%

“…Although it is occasionally preceded by and/or associated with vesicle formation, it is always associated with a juxta-epithelial inflammatory reaction followed by fibro-elastic change of the lamina propria with epithelial atrophy leading to stiffness of the oral mucosa causing trismus and inability to eat. [3,4] When compared to other diseases, OSMF is considered to be potentially harmful as it induces the overlying epithelium to undergo malignant transformation. Thus, OSMF is called as a precancerous condition.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Fibrotic Changes in OSMF:A Retrospective Study Using Special Stains and Polarizing Microscopy

Ikram

Jeddy

2017

IJMDS

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“…OSE has been graded histologically into four stages, depending on fibroblastic response, hyalinization and inflammation [2]. Binnie and Cawson [3] have reported a homogenous collagenous subepithelial zone along with degeneration of muscle fibers.…”

Section: Discussionmentioning

confidence: 99%

Benefit of Using Muscle Relaxants in the Routine Treatment Protocol of Oral Submucosal Fibrosis: A Pilot Study

Nichlani

Jagade

Ganeshan

2011

Indian J Otolaryngol Head Neck Surg

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The aim of this present work is to describe the nature and extent of fibrosis within muscle and to correlate this with the mouth opening (MO) in OSE patients and to prove our results in improvement of mouth opening in patients with OSMF with use of ''muscle relaxants'' along with other modalities of treatment . The study was conducted on 40 patients who visited our outpatient department with grade 3 (\19 mm) mouth opening. 20 of these patients underwent the routine treatment protocol of weekly injection of hyaluronidase with hydrocortisone and antioxidant capsules with added lycopene for 1 month. The remaining test subjects in addition to the routine injections and antioxidants were given skeletal muscle relaxants like thiocolchicoside or chlorzoxazone. The mouth opening (interincisal distance of maxillary and mandibular incisors at maximum possible mouth opening) was measured and graded as follows: grade 1 ([40 mm), grade 2 (20-39 mm) and grade 3 (\19 mm) with the help of vernier callipers after the study period of 1 month. 17 out of the 20 test patients who received muscle relaxants in addition to the routine protocol showed marked improvement with shift from grade 3 (\19 mm) to grade 1 ([40 mm) i.e. a greater than 20 mm improvement in mouth opening. Using muscle relaxants as a adjuvant therapy in the routine protocol of treatment of oral submucosal fibrosis will not only cater and halt the problem of fibrosis but also will take care of the muscle spasm and inflammation which also inadvertently contribute to the restricted mouth opening. We found excellent improvement on adding muscle relaxants to the routine protocol which was not just an objective but also a subjective success.

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Oral submucous fibrosis

Cited by 473 publications

References 11 publications

Concomitant Association of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma and Incidence of Malignant Transformation of Oral Submucous Fibrosis in a Population of Central India: A Retrospective Study

Concomitant Association of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma and Incidence of Malignant Transformation of Oral Submucous Fibrosis in a Population of Central India: A Retrospective Study

Evaluation of Fibrotic Changes in OSMF:A Retrospective Study Using Special Stains and Polarizing Microscopy

Benefit of Using Muscle Relaxants in the Routine Treatment Protocol of Oral Submucosal Fibrosis: A Pilot Study

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