Oral stimulations induce apnoea in newborn kittens

Wallois, Fabrice; Khater-Boidin, Josette; Dusaussoy, Françoise; Duron, B

doi:10.1097/00001756-199307000-00016

Cited by 15 publications

(8 citation statements)

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“…Therefore, the effects of 5-HT resulted, at least in part, from activation of 5-HT2 receptors. The 5-HT-induced apnoeas exhibited much the same pattern as various reflex central apnoeas previously described in anaesthetized or decerebrate kittens (Trippenbach, Kelly & Marlot, 1985;Wallois, Khater-Boidin, Dusaussoy & Duron, 1993;Khater-Boidin, Wallois, Toussaint & Duron, 1994). Thus, 5-HT could be involved in the central mechanisms responsible for the generation of these apnoeas.…”

Section: Experimental Approachsupporting

confidence: 75%

“…250-1000 nmol in 0 05 ml artificial cerebrospinal fluid) used in in vitro preparations (NMorin et al 1991). (Trippenbach, Kelly & Marlot, 1985;Wallois, Khater-Boidin, Dusaussoy & Duron, 1993;Khater-Boidin, Wallois, Toussaint & Duron, 1994 (Skoglund, 1960;Duron & Marlot, 1980). Therefore, as postulated by Duron & Marlot (1980), the nervous control of breathing in the newborn may well depend essentially on the non-specific reticular formation.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Central effects of 5‐HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens.

Khater-Boidin¹,

Rose²,

Duron³

1996

The Journal of Physiology

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1. In decerebrate kittens (it = 29), electrical activity" was studied in the 3rd intercartilaginous (inspiratory), the 9th internal intercostal (expiratory) and the hypoglossally innervated muscles (geniohyoid m. and sternohyoid m.) evoked by the application of 5-HT (a = 16) or related agents (5-HTlA agonist, 8-OH-DPAT (a7 = 6) and 5-HT2 agonist, DOI (n = 4)) to the floor of the IVth ventricle. 2. The application of a control solution (n = 2) produced no significant changes either in minute inspiratory frequency (F1) or in the electrical activity of the muscles studied. Except for these controls, only one trial with one dose of one drug was performed in a given kitten. 3. A dose-related decrease in Fi was observed in response to 5-HT. Low doses (50-500 nmol,

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Section: Experimental Approachsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 96%

Central effects of 5‐HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens.

Khater-Boidin¹,

Rose²,

Duron³

1996

The Journal of Physiology

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“…Accordingly, mice lacking the NMDARl gene develop in utero but die rapidly after birth from inability to feed and respiratory failure (Forrest et al, 1994). However, some signs of immaturity of the autonomic functions are present at birth, such as a prolonged reflex apnea and changes in firing activity of inspiratory neurons (Suthers et al, 1977;Wallois et al, 1993). The alteration of NMDA-induced firing activity and the changes in spike characteristics might account for the slight but significant developmental changes in the operating of the autonomic functions.…”

Section: Discussionmentioning

confidence: 99%

Developmental Study of N‐Methyl‐d‐Aspartate‐induced Firing Activity and Whole‐cell Currents in Nucleus Tractus Solitarii Neurons

Vincent¹,

Jean²,

Tell³

1996

Eur J of Neuroscience

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Whole-cell recordings of rat nucleus tractus solitarii (NTS) neurons were performed on a slice preparation. We investigated possible postnatal changes in firing activities and currents induced by N-methyl-D-aspartate (NMDA) application. A total of 42 neurons were selected and fell into the following age groups: 0-5 days (n = 15), 10-15 days (n = 9) and 30-60 days (adult, n = 18). During this period, input resistance and spike duration decreased by approximately 40%. At all ages, bath application of NMDA elicited a bursting firing activity when the membrane potential was held between -60 and -75 mV. However, in the youngest cells the rhythmic bursting activity was irregular and was characterized by a progressive firing inactivation during a burst. In a tetrodotoxin-containing saline, NMDA-induced oscillations of membrane potential were retained in all age groups. The membrane current-voltage relationship of the NMDA-induced inward current (INMDA) was characterized by a region of negative slope conductance which was similar in all age groups. Thus the voltage-dependent block of INMDA is present in NTS neurons from birth, allowing NTS neurons to display membrane potential oscillations. However, postnatal maturation of repolarizing conductances, as suggested by changes in spike characteristics, could render the oscillatory activity more stable than at birth.

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“…However, depending on the in vitro preparation used, the developmental aspects, such as possible postnatal changes in the swallowing mechanisms, should not be overlooked. Interestingly, and somewhat paradoxically, some data have suggested that although swallowing is a vital function, the underlying mechanisms may be not fixed at birth (206,229,271,272,315,357,359). Finally, studies on complex pattern generators such as those operating in mammals will no doubt greatly benefit from the latest methodological approaches.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Brain Stem Control of Swallowing: Neuronal Network and Cellular Mechanisms

Jean¹

2001

Physiological Reviews

1,015

927

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Swallowing movements are produced by a central pattern generator located in the medulla oblongata. It has been established on the basis of microelectrode recordings that the swallowing network includes two main groups of neurons. One group is located within the dorsal medulla and contains the generator neurons involved in triggering, shaping, and timing the sequential or rhythmic swallowing pattern. Interestingly, these generator neurons are situated within a primary sensory relay, that is, the nucleus tractus solitarii. The second group is located in the ventrolateral medulla and contains switching neurons, which distribute the swallowing drive to the various pools of motoneurons involved in swallowing. This review focuses on the brain stem mechanisms underlying the generation of sequential and rhythmic swallowing movements. It analyzes the neuronal circuitry, the cellular properties of neurons, and the neurotransmitters possibly involved, as well as the peripheral and central inputs which shape the output of the network appropriately so that the swallowing movements correspond to the bolus to be swallowed. The mechanisms possibly involved in pattern generation and the possible flexibility of the swallowing central pattern generator are discussed.

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Oral stimulations induce apnoea in newborn kittens

Cited by 15 publications

References 0 publications

Central effects of 5‐HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens.

Central effects of 5‐HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens.

Developmental Study of N‐Methyl‐d‐Aspartate‐induced Firing Activity and Whole‐cell Currents in Nucleus Tractus Solitarii Neurons

Brain Stem Control of Swallowing: Neuronal Network and Cellular Mechanisms

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