Central effects of 5‐HT on activity of respiratory and hypoglossally innervated muscles in newborn kittens.

Khater-Boidin, Josette; Rose, Dominique; Duron, B

doi:10.1113/jphysiol.1996.sp021590

Cited by 12 publications

(11 citation statements)

References 20 publications

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“…It would appear that after decerebration, the respiratory frequency remains within the physiological range but that decerebration does not alter the differences in respiratory rhythm existing between species. This is indicated by the results of Mortola & Noworaj (1985) showing that intact kittens breathe more slowly (mean F i = 80) than intact rat pups (mean F i = 109), and our finding that under our control conditions, after decerebration, the mean respiratory frequency of newborn kittens (55 ± 6 bursts/min; Khater‐Boidin et al . 1996) is lower than that of newborn rats (80 ± 18 bursts/min).…”

Section: Discussionsupporting

confidence: 74%

“…In vivo , in the present newborn rats as in newborn kittens (Khater‐Boidin et al . 1996), centrally applied 5‐HT had a depressant effect on respiratory rate that is mediated via activation of 5‐HT 2 receptors.…”

Section: Discussionmentioning

confidence: 98%

“…Nevertheless, as the 5‐HT central respiratory action differs between newborn and adult, as demonstrated in the cat (Rose et al . 1995; Khater‐Boidin et al . 1996), it is necessary to determine when during the postnatal period the change occurs from the immature to the adult pattern of response, as this could correspond to a critical period as far as SIDS is concerned (Kinney et al .…”

Section: Discussionmentioning

confidence: 99%

“…A recent study on the effect of 5-HT and related agents in decerebrate newborn kittens in vivo (Khater-Boidin et al, 1996) reported somewhat different results. In this preparation, 5-HT applied to the¯oor of the IVth ventricle, acting mainly via 5-HT 2 receptors, induced a dose-related decrease in Fi and a powerful activation of both expiratory muscles and tongue muscles, which are activated in the course of expiration.…”

Section: Introductionmentioning

confidence: 93%

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Central effects of 5‐HT on respiratory rhythm in newborn rats in vivo

Khater-Boidin

Rose

Glérant

et al. 1999

Eur J of Neuroscience

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The role of 5-HT in inducing apnoeas (a major element in sudden infant death syndrome) is controversial because while 5-HT is a respiratory depressant in vivo, it evokes respiratory analeptic effects when applied to the isolated brainstem of the newborn rat. In decerebrate newborn rats, the electrical activity of the diaphragm and that of a hypoglossally innervated tongue muscle, as well as the cardiac frequency (Fc), were recorded before and after the application of 5-HT and related agents to the floor of the IVth ventricle. To assess the spontaneous variability in inspiratory frequency (Fi) and Fc, a sham group was studied. A decrease in Fi was observed in response to 5-HT. This respiratory depressant effect was associated with an activation of the tongue muscle, but there was no change in Fc. Application of agonists elicited a small increase in Fi linked to activation of 5-HT1A receptors, and decreases in both Fi and the activity of the tongue muscle resulting predominantly from activation of 5-HT2 receptors. The decrease in Fi was much smaller in newborn rats than that reported in newborn kittens. Indeed, in newborn rats, we did not observe long-lasting apnoeas. Our results differ from those obtained from the newborn rat in vitro, inasmuch as in vivo 5-HT essentially depressed the respiratory rhythm generator. The role of the afferent system appears to be crucial in modulating the action of 5-HT.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Central effects of 5‐HT on respiratory rhythm in newborn rats in vivo

Khater-Boidin

Rose

Glérant

et al. 1999

Eur J of Neuroscience

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“…Some of these apnoeas showed airways obstructions (Hilaire et al, 1993). Application of 5-HT or other serotonergic drugs to the IVth ventricle in decerebrated kittens also induces apnoeas (Khater-Boidin et al, 1996). Also, transgenic mice lacking 5-HT 2A R showed increased incidence for SAS (Popa et al, 2005).…”

Section: 5-ht and Respiratory Disordersmentioning

confidence: 99%

The role of serotonin in respiratory function and dysfunction

Hilaire¹,

Voituron²,

Menuet³

et al. 2010

Respiratory Physiology & Neurobiology

144

121

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Serotonin (5-HT) is a neuro-modulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre-and postnatal development of neural circuits. The functional implications of 5-HT is particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration.

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