Oral squamous cell carcinoma pathogenesis and role of p53 protein

Chandra, Akhilesh; Sebastian, Bastian Thattil; Agnihotri, Archna

doi:10.4103/2249-9725.123976

Cited by 1 publication

(2 citation statements)

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“…Due to many genotoxic or chemical insults when genomic DNA damage is being identified, p53 gene activated and stop cell to divide further at the G1-S boundary and it repairs rather than replicates the error in the genetic code. If the chromosomal damage is too great, p53 gene activate apoptotic pathways [15].…”

Section: Function Of P53 As a Tumor Suppressor Genementioning

confidence: 99%

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Molecular Pathogenesis of Oral Squamous Cell Carcinoma

Jain¹

2020

Squamous Cell Carcinoma - Hallmark and Treatment Modalities

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Oral carcinogenesis is a molecular and histological multistage process featuring genetic and phenotypic molecular markers which involves enhanced function of several protooncogenes, oncogenes and/or the deactivation of tumor suppressor genes, resulting in the over activity of growth factors and its cell surface receptors, which could enhance messenger signaling intracellularly, and/or leads to the increased production of transcription factors. Alone oncogenes are not responsible for carcinogenesis, genes having tumor suppressor activity, leads to a phenotypic change in cell which is responsible for increased cell proliferation, loss of cellular cohesion, and the ability to infiltrate local tissue and spread to distant sites. Understanding the molecular interplay of both onco and tumor genes will allow more accurate diagnosis and assessment of prognosis, which might lead the way for novel approaches to treatment.

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Section: Function Of P53 As a Tumor Suppressor Genementioning

confidence: 99%

“…This term refers to the acquisition of oncogenic properties by the mutant form of p53 protein, compared with the mere inactivation of the protein. During tumorigenesis both the dominant negative and GOF effects may play a significant role in missense mutations of TP53 protein [15].…”

Section: Gain Of Functionmentioning

confidence: 99%

Molecular Pathogenesis of Oral Squamous Cell Carcinoma

Jain¹

2020

Squamous Cell Carcinoma - Hallmark and Treatment Modalities

View full text Add to dashboard Cite

show abstract

Oral squamous cell carcinoma pathogenesis and role of p53 protein

Cited by 1 publication

References 1 publication

Molecular Pathogenesis of Oral Squamous Cell Carcinoma

Molecular Pathogenesis of Oral Squamous Cell Carcinoma

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