Oral squamous cell carcinoma (OSCC) – molecular, viral and bacterial concepts

Polz-Gruszka, Dorota; Macieląg, Paweł; Fołtyn, Sylwia; Polz‐Dacewicz, Małgorzata

doi:10.26444/jpccr/71469

Cited by 6 publications

(5 citation statements)

References 41 publications

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“…Oral cancer is a subtype of head and neck cancers occurred within oral cavity. There are several types of oral cancers with 90% as squamous cell carcinoma [5]. Squamous cell carcinoma is malignant neoplasm arised from stratified squamous cells commonly occurred at lip, tongue, and mouth floor [6].…”

Section: Issn: 2574 -1241mentioning

confidence: 99%

The Effect of Terung Belanda (Cyphomandra betacea Sendtn.) Peels Fruit Extract on Tongue Cancer Cells

Hague¹

2020

BJSTR

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Oral cancer is a common malignancy in developing countries that 90% is squamous cell carcinoma with its most frequent predilection on the tongue. Treatments for tongue cancer include surgery, radiotherapy, and chemotherapy. However, those treatments generate various side effects. Herbal based treatment from the peels of tamarillo (Cyphomandra betacea Sendtn.) fruit is a new alternative one that is expected to minimize the side effects of modern therapies. The peels of tamarillo fruit contain polyphenolic compounds such as phenolic acid and flavonoid which allegedly have anticancer effect. Therefore, this study was conducted to determine the effect of 70% ethanol extract of tamarillo peels fruit on tongue squamous cell carcinoma (HSC-3) cell line viability. This in vitro experimental study consisted of treatment, positive and negative control groups. The treatment groups which were given the extract consisted of seven concentrations namely 20%, 10%, 5%, 2.5%, 1.25%, 0.625%, and 0.3125%. The culture medium without treatment was used as the negative control while H 2 O 2 3% used as the positive control. The result indicator was the cell viability test using a spectrophotometer with 450 nm wavelength. Data analysis used in this study was Shapiro-Wilk normality test, one-way Analysis of Variance Test (ANOVA), and post hoc LSD test. The 5% concentration of 70% ethanol extract tamarillo peels was no significant difference (p > 0,05) compared to those of positive control of H 2 O 2 3%. Extract with 5% concentration is effective in decreasing the viability of HSC-3 cells. potency of natural herbal product to treat diseases like cancer [11].

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Section: Issn: 2574 -1241mentioning

confidence: 99%

The Effect of Terung Belanda (Cyphomandra betacea Sendtn.) Peels Fruit Extract on Tongue Cancer Cells

Hague¹

2020

BJSTR

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“…Head and neck cancer is the sixth most frequently occurring malignant tumour in the world [10,11]. About 550,000 new cases are diagnosed, leading to about 380,000 deaths annually worldwide due to this cancer [12].…”

Section: Objectivementioning

confidence: 99%

The role of oxidative stress in cancer associated with viral infection

Kliszczewska¹,

Strycharz-Dudziak²,

Polz‐Dacewicz³

2018

J Pre Clin Clin Res.

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Introduction. The role of oxidative stress in the pathogenesis of neoplastic diseases, including its connection with viral infections, is the subject of many publications. The results of numerous researches have revealed that virus-induced phagocyte activation is associated with oxidative stress, not only because reactive oxygen species (ROS) are released, but also because activated phagocytes can release cytokines, such as tumour necrosis factor (TNF-alpha) or interleukin-1 (IL-1). Objective. The purpose of this review is to analyze the role of ROS in the pathogenesis of head and neck cancer and correlation between ROS and viruses, especially Epstein-Barr virus (EBV) and Human papillomavirus (HPV), in malignant tumour development in this area. State of knowledge. The effects of an increased amount of ROS or reactive nitrate species (RNS) with a simultaneous reduction of antioxidants are noticed in various cancers, including head and neck cancer. Increased oxidative stress is also associated with disorders in the antioxidant defence system. HPV and EBV, which are important risk factors for head and neck cancer, can act via ROS-based mechanisms. Long-term expression of the Epstein-Barr nuclear antigen 1 (EBNA1) causes increased ROS and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase level. During expression of HPV16infected cells, RNS increase E6 and E7 levels, thereby increasing the level of DNA damage in the cell. ROS are also involved in many benign oral disorders. Conclusion. Reactive oxygen species are involved in various pathological processes in the environment of chronic oxidative stress, including carcinogenicity. ROS contribute to the development of head and neck cancer through many risk factors, such as connection with viruses.

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“…In accordance with their capacity to cause cancer, more than 130 different HPV kinds have been recognized and are divided into modestly dangerous and extremely dangerous categories [9][10][11]. Squamous cell carcinomas of the oropharynx (OPSCCs) with HPV are a separate clinical condition with significantly better survival than OPSCCs without HPV, which are frequently linked to both alcohol intake and tobacco addiction [12,13].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Oral Squamous Cell Carcinoma Patients Using Polymerase Chain Reaction Regarding the Prevalence of Human Papillomavirus Types 16 and 18

Jeergal,

Fatma

et al. 2024

Cureus

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Background: Epstein-Barr virus, human papillomavirus (HPV), and herpes simplex virus type 1 (HSV-1) are examples of viruses that have been associated with the development of oral squamous cell carcinoma (OSCC). These viruses can infect various epithelial tissues in the human body. The use of incredibly accurate cellular biology techniques, such as the polymerase chain reaction (PCR), which permits the rapid identification of viruses following infection, has increased. The parameters of human head and neck oncology have been widened. Aim: In this study, using the PCR, the presence of HPV variants such as HPV 18 and HPV 16 in patients with OSCC was assessed. Materials and methods: Tissue specimens were obtained from clinically presumed OSCC individuals taken as cases, and tissues from the retromolar region were obtained from people who experienced an operation for partially and completely impacted tooth and taken as controls. The study included 80 samples divided into two separate categories: case category (n = 40) = OSCC-diagnosed individuals; control category (n = 40) = controls with a comparable age. For verification of the diagnosis, a specimen of the tissue has been processed and sections have been stained and inspected for standard hematoxylin and eosin stain. Deoxyribonucleic acid (DNA) was extracted from the leftover histopathologically verified tissue specimens and then exposed to PCR for the assessment of HPV infiltration. Results: It was observed in this research that 22 cases out of 40 cases of OSCC were found positive for HPV-DNA. While 12 out of 40 age-matched healthy controls were found positive for HPV-DNA. Out of 40 cases of OSCC, 12 cases were found positive for HPV 16. While six out of 40 age-matched healthy controls were found positive for HPV 16. Six cases out of 40 cases of OSCC were found positive for HPV 16. While two out of 40 age-matched healthy controls were found positive for HPV 18. Four cases out of 40 cases of OSCC were found positive for HPV 16. While four out of 40 age-matched healthy controls were found positive for HPV 16 and HPV 18. On carrying out statistical analysis, the variation between the two categories was non-meaningful statistically (p = 0.662). However, the prevalence was greater in the case (OSCC) subgroup. Conclusion: When evaluated against controls in the current investigation, OSCC cases had a greater level of HPV expression and a greater proportion of HPV 16 positives. However, there was no statistically noteworthy change.

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Oral squamous cell carcinoma (OSCC) – molecular, viral and bacterial concepts

Cited by 6 publications

References 41 publications

The Effect of Terung Belanda (Cyphomandra betacea Sendtn.) Peels Fruit Extract on Tongue Cancer Cells

The Effect of Terung Belanda (Cyphomandra betacea Sendtn.) Peels Fruit Extract on Tongue Cancer Cells

The role of oxidative stress in cancer associated with viral infection

Evaluation of Oral Squamous Cell Carcinoma Patients Using Polymerase Chain Reaction Regarding the Prevalence of Human Papillomavirus Types 16 and 18

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