The Effect of Terung Belanda (Cyphomandra betacea Sendtn.) Peels Fruit Extract on Tongue Cancer Cells

Abstract

Oral cancer is a common malignancy in developing countries that 90% is squamous cell carcinoma with its most frequent predilection on the tongue. Treatments for tongue cancer include surgery, radiotherapy, and chemotherapy. However, those treatments generate various side effects. Herbal based treatment from the peels of tamarillo (Cyphomandra betacea Sendtn.) fruit is a new alternative one that is expected to minimize the side effects of modern therapies. The peels of tamarillo fruit contain polyphenolic compounds such as phenolic acid and flavonoid which allegedly have anticancer effect. Therefore, this study was conducted to determine the effect of 70% ethanol extract of tamarillo peels fruit on tongue squamous cell carcinoma (HSC-3) cell line viability. This in vitro experimental study consisted of treatment, positive and negative control groups. The treatment groups which were given the extract consisted of seven concentrations namely 20%, 10%, 5%, 2.5%, 1.25%, 0.625%, and 0.3125%. The culture medium without treatment was used as the negative control while H 2 O 2 3% used as the positive control. The result indicator was the cell viability test using a spectrophotometer with 450 nm wavelength. Data analysis used in this study was Shapiro-Wilk normality test, one-way Analysis of Variance Test (ANOVA), and post hoc LSD test. The 5% concentration of 70% ethanol extract tamarillo peels was no significant difference (p > 0,05) compared to those of positive control of H 2 O 2 3%. Extract with 5% concentration is effective in decreasing the viability of HSC-3 cells. potency of natural herbal product to treat diseases like cancer [11].

Anti-inflammatory Effect of Tamarillo (Solanum betaceum Cav.) Fruit Peel Ethanol Extract: Study of Carrageenan-Induced Buccal Mucosa on Rats

“…6 Indonesia has a lot of herbal trees, at least there are 30.000 herbal trees with 7.500 among them have herbal medicine properties. [7][8][9] Parts of herbal trees can be used as herbal medicine such as fruit, flower, skin, leaves, and rhizome. 10 One of the herbal trees that started to be used a lot as herbal remedies is Dutch eggplant or Tamarillo (Solanum betaceum Cav.).…”