Oral squamous cell carcinoma: Key clinical questions, biomarker discovery, and the role of proteomics

Riparsaponin isolated from Homonoia?riparia Lour induces apoptosis of oral cancer cells

“…OSCC exhibits a marked propensity for invasive growth and metastasis, leading to damage of the original tissues or that of distant organs (2,4). The predominant treatment strategy for OSCC is radical surgery and postoperative chemoradiation (4). Marked improvements have been made in clinical diagnosis and management of OSCC; however, high recurrence rates and low 5-year survival rates have remained constant for several decades (7).…”

“…OSCC commonly occurs in the tissues of the oral cavity, including the gingiva, tongue, lip, hard palate, buccal mucosa and mouth floor (4,6). OSCC exhibits a marked propensity for invasive growth and metastasis, leading to damage of the original tissues or that of distant organs (2,4). The predominant treatment strategy for OSCC is radical surgery and postoperative chemoradiation (4).…”

“…It has been reported that developing countries have the highest incidence rates of OSCC and it is expected that the incidence will continue to increase (4); furthermore, OSCC commonly occurs in middle-aged and elderly males because of tobacco and alcohol use (5). OSCC commonly occurs in the tissues of the oral cavity, including the gingiva, tongue, lip, hard palate, buccal mucosa and mouth floor (4,6). OSCC exhibits a marked propensity for invasive growth and metastasis, leading to damage of the original tissues or that of distant organs (2,4).…”

“…The AE was subjected to column chromatography (CC) over a silica gel (200-300 mesh), eluting with ethyl acetate-acetone (20:1, 15:1, 10:1, 5:1, 3:1 and 1:1) to yield four subfractions I-IV on the basis of the results of thin layer chromatography (TLC) analysis: The aforementioned CC elution samples (3 µl) were analyzed using silica gel G thin layer plate, and the chromatography was run for 8 cm using an ethyl acetate-acetone mobile phase (10:1, 5:1 and 2:1) and the TLC spots were visualized using 10% sulfuric acid alcohol chromogenic agent. Fraction III was repeatedly subjected to CC over a silica gel (200-300 mesh), eluting with ethyl acetate-acetone (15:1, 10:1, 5:1, 3:1 and 1:1) to yield four subfractions III 1 -III 4 . RSP was crystallized from III 2 .…”

Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers

“…In SCC, the metastatic rates are estimated as high as 5% [14]. In oral SCC, for instance, cell adhesion molecules (specifically CD44, members of the tumor necrosis factor, cytokine family like FasL and TRAIL, some interleukins, ILs, such as IL-6, IL-8, IL-12, and IL-23, vascular endothelial growth factor, and epidermal growth factor receptor, EGFR) play an important role in metastases [15]. The dermoscopic pattern of invasive SCC has been shown to depend on the grade of histopathological differentiation, namely (i) well-differentiated SCC displays signs of keratinization as opaque, yellow scales, a central mass of keratin, structureless white areas, and yellow keratotic follicular plugs surrounded by a white rim (white circle) and (ii) poorly differentiated subtypes commonly lack signs of keratinization, displaying a predominant red color, which results from dense vascularity [16] .…”