Oral squamous cell carcinoma: epidemiological study and risk factor assessment based on a 39-year series

Capote-Moreno, Ana; Muñoz-Guerra, M.F.; Sastre-Pérez, Jesús; Escorial-Hernández, V.; Rodríguez-Campo, F.J.; García, Tania García; Naval-Gías, Luis

doi:10.1016/j.ijom.2020.03.009

Cited by 63 publications

(50 citation statements)

References 29 publications

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“…[1] Although various treatment options are available for OSCC, such as surgery, radiotherapy, and chemotherapy, [2] their therapeutic potential has been limited due to high risk of tissue damages, systemic toxicity, and low therapeutic effects, leading to an average five-year survival rate below 60%. [3] Particularly, conventional anticancer therapy always induces severe oral disabilities and malfunctions, [4] such as eating, tasting, and speaking, and sometimes even induced unwanted facial disfigurement, which profoundly influence fundamental activities and life quality of survivors' daily life. [5] Therefore, an alternative treatment for OSCC with higher anticancer efficiency while minimal influence to oral functions and physical appearance is greatly needed.…”

Section: Doi: 101002/adma202005295mentioning

confidence: 99%

Mesenchymal Stem Cells Functionalized Sonodynamic Treatment for Improving Therapeutic Efficacy and Compliance of Orthotopic Oral Cancer

Sun

Zhang

et al. 2020

Advanced Materials

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Despite multiple treatment options being available, many critical challenges are still ongoing in the treatment of oral squamous cell carcinoma (OSCC). Particularly, the major hurdle is to avoid facial disfigurement and oral function disability during treatment. Herein, nanoengineered mesenchymal stem cells (MSCs) are developed as a supersonosensitizer, named M/LPV/O2, for improving nondestructive sonodynamic therapy (SDT) against OSCC along with good therapeutic compliance. M/LPV/O2 is composed of an MSCs membrane functionalized liposomal formulation of oxygen‐loading perfluorocarbon and sonosensitizer verteporfin (M/LPV/O2), which can not only increase circulation and targeting efficacy but also supply oxygen to overcome tumor‐hypoxia‐associated resistance in SDT, resulting in enhanced therapeutic outcomes in vitro and in vivo. It is identified that M/LPV/O2 effectively stimulates the generation of reactive oxygen species even in hypoxic conditions, and consequently tremendously induces cancer cell death. In addition, M/LPV/O2 displays good tumor accumulation and penetration under ultrasound stimulation, and efficiently induces tumor inhibition and even abrogation, leading to prolonged survival of tumor‐bearing mice. Importantly, M/LPV/O2‐based SDT exhibits minimal systemic adverse effects and successfully maintains oral functions with no facial tissue damage. Therefore, these studies provide a promising therapeutic strategy for OSCC, which has a potential to enhance life quality and compliance after treatment.

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Section: Doi: 101002/adma202005295mentioning

confidence: 99%

Mesenchymal Stem Cells Functionalized Sonodynamic Treatment for Improving Therapeutic Efficacy and Compliance of Orthotopic Oral Cancer

Sun

Zhang

et al. 2020

Advanced Materials

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“…Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity, representing 95% of all malignant neoplasms in this anatomical site ( 1 ). In spite of the strides which have been made in multimodal therapy, the low survival rates have not significantly improved over the last decades ( 1 , 2 ). Additionally, most patients with OSCC may be affected by several morbidities, including severe functional and cosmetic defects, mucositis, xerostomia and osteoradionecrosis, which impair the patients’ quality of life ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population

Jm¹,

Fs²,

Santos‐Silva³

et al. 2021

Med Oral

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Background Among the oral potentially malignant disorders, leukoplakia stands out as the most prevalent. The purpose of this study was to analyse the clinical-pathological features of oral leukoplakia in groups of patients from three major pathology centers in two different regions of Brazil, in order to determine which factors would be associated to the clinical risk of malignant transformation. Material and Methods A total of 148 patients was analyzed, and data regarding gender, age, site, classification of the clinical subtype, harmful habits such as use of tobacco and alcohol, time of evolution and presence of dysplasia were collected. The association between risk factors and malignant transformation was investigated using the chi-square test and Fischer's exact test for correlation of variables. A significance level of 5% ( p ≤0.05) was used. Results The mean age of the patients was 60 years, and 56% were female. Most of the lesions (34,5%) were located in the lateral and ventral regions of the tongue. Of the 148 patients, ninety had clinical follow-up. Malignant transformation occurred in 13 patients (8.8%), with an average of 44 months of follow up. Conclusions Non-smoker, nonhomogeneous clinical presentation, location at the tongue, and the presence of high degree of dysplasia were statistically relevant factors associated with a higher risk of transformation transformation. Key words: Potentially malignant disorders, leukoplakia, malignant transformation, squamous cell carcinoma.

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“…According to the GLOBO-CAN 2018 report, 117,384 of the 354,846 newly diagnosed OCSCC patients died from the disease [5]. Therefore, OCSCC poses a considerable burden to the healthcare systems in different regions [6][7][8][9][10][11]. The majority of OCSCC patients present with a locally advanced disease, and the main therapeutic strategy is tumor wide excision plus radical neck dissection, followed by adjuvant radiotherapy with or without chemotherapy [12,13].…”

Section: Introductionmentioning

confidence: 99%

Metronomic Therapy in Oral Squamous Cell Carcinoma

Chen

2021

JCM

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Metronomic therapy is characterized by drug administration in a low-dose, repeated, and regular manner without prolonged drug-free interval. The two main anticancer mechanisms of metronomic therapy are antiangiogenesis and immunomodulation, which have been demonstrated in several delicate in vitro and in vivo experiments. In contrast to the traditional maximum tolerated dose (MTD) dosing of chemotherapy, metronomic therapy possesses comparative efficacy but greatlydecreases the incidence and severity of treatment side-effects. Clinical trials of metronomic anticancer treatment have revealed promising results in a variety cancer types and specific patient populations such as the elderly and pediatric malignancies. Oral cavity squamous cell carcinoma (OCSCC) is an important health issue in many areas around the world. Long-term survival is about 50% in locally advanced disease despite having high-intensity treatment combined surgery, radiotherapy, and chemotherapy. In this article, we review and summarize the essence of metronomic therapy and focus on its applications in OCSCC treatment.

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Oral squamous cell carcinoma: epidemiological study and risk factor assessment based on a 39-year series

Cited by 63 publications

References 29 publications

Mesenchymal Stem Cells Functionalized Sonodynamic Treatment for Improving Therapeutic Efficacy and Compliance of Orthotopic Oral Cancer

Mesenchymal Stem Cells Functionalized Sonodynamic Treatment for Improving Therapeutic Efficacy and Compliance of Orthotopic Oral Cancer

Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population

Metronomic Therapy in Oral Squamous Cell Carcinoma

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