Mesenchymal Stem Cells Functionalized Sonodynamic Treatment for Improving Therapeutic Efficacy and Compliance of Orthotopic Oral Cancer

Abstract

Despite multiple treatment options being available, many critical challenges are still ongoing in the treatment of oral squamous cell carcinoma (OSCC). Particularly, the major hurdle is to avoid facial disfigurement and oral function disability during treatment. Herein, nanoengineered mesenchymal stem cells (MSCs) are developed as a supersonosensitizer, named M/LPV/O2, for improving nondestructive sonodynamic therapy (SDT) against OSCC along with good therapeutic compliance. M/LPV/O2 is composed of an MSCs membrane functionalized liposomal formulation of oxygen‐loading perfluorocarbon and sonosensitizer verteporfin (M/LPV/O2), which can not only increase circulation and targeting efficacy but also supply oxygen to overcome tumor‐hypoxia‐associated resistance in SDT, resulting in enhanced therapeutic outcomes in vitro and in vivo. It is identified that M/LPV/O2 effectively stimulates the generation of reactive oxygen species even in hypoxic conditions, and consequently tremendously induces cancer cell death. In addition, M/LPV/O2 displays good tumor accumulation and penetration under ultrasound stimulation, and efficiently induces tumor inhibition and even abrogation, leading to prolonged survival of tumor‐bearing mice. Importantly, M/LPV/O2‐based SDT exhibits minimal systemic adverse effects and successfully maintains oral functions with no facial tissue damage. Therefore, these studies provide a promising therapeutic strategy for OSCC, which has a potential to enhance life quality and compliance after treatment.

Polydopamine-coated UiO-66 nanoparticles loaded with perfluorotributylamine/tirapazamine for hypoxia-activated osteosarcoma therapy

“…Liang et al [ 38 ] demonstrated that PFC@porphyrin NPs could serve as an important oxygen reservoir and relieve tumor hypoxia to enhance PDT. Sun et al [ 39 ] developed a mesenchymal stem cell membrane-functionalized liposomal formulation of the sonosensitizer verteporfin and oxygen-loaded PFC, resulting in enhanced SDT therapeutic effects. Although PFC has a high affinity for oxygen, its oxygen release efficacy is quite low.…”

“…For example, Zhang et al [ 27 ] reported an erythrocyte membrane-cloaked MOF-based nanomaterial to reduce NP elimination by the immune system. Sun et al [ 39 ] constructed a mesenchymal stem cell membrane-functionalized biomimetic sonosensitizer, which increased circulation and targeting efficacy. Further studies should focus on enhancing the permeability and retention effect of nanomaterials in the tumor while reducing immune clearance.…”

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

“…The nanoliposomes showed approximately 84% release of DOX under LIFU irradiation for 8 h. The drug release can be prompted by LIFU in the nanoliposomes and enhances the inhibition of HepG2 cells proliferation [154]. For targeting the specific cancer cells, Sun et al, 2020 [155], reported the work of mimicking the mesenchymal stem cell membrane (coating material) and liposomes (core material). The developed mesenchymal stem cell membrane functionalized liposomal formulation delivered oxygen-loaded perfluorocarbon and verteporfin (sonosensitizer) to the target site.…”

Charge-reversal nanomedicine based on black phosphorus for the development of A Novel photothermal therapy of oral cancer

“…However, to prevent the spread of cancer cells, complete tumor resection is required. Therefore, a large number of patients' entire tongues or gums have been removed as well as faces have been cut, which may lead to the loss of language, masticatory, gustation, and other basic functions of the patient, and bring a very serious impact on the patient's life (Huang & O’Sullivan, 2013 ; Sun et al., 2020 ). So it is urgent to develop non-operative oral cancer treatment methods to ensure the treatment effect and the quality of life of patients to the maximum extent.…”