Oral Squamous Cell Carcinoma: Diagnosis and Treatment Planning

Deshmukh, Vijay Dnyandev; Shekar, K. Chandra

doi:10.1007/978-981-15-1346-6_81

Cited by 15 publications

(12 citation statements)

References 32 publications

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“…Consequently, the success of OSCC treatment depends on an appropriate and quick intervention at the first stage of the tumor [ 18 ]. The conventional therapeutic approaches are based on surgery, radiotherapy, systemic chemotherapy, or combinations thereof [ 19 ]; however, these strategies are often aggressive, thus negatively affecting patients’ quality of life, while likewise being often unsatisfactory in terms of survival rate. Considering the high incidence of OSCC, it is still necessary to identify novel bioactive compounds as well as to design new drug delivery systems aimed at increasing the efficacy of conventional treatments, minimizing their adverse effects and thus allowing their drawbacks to be overcome.…”

Section: Oral Squamous Cell Carcinoma (Oscc)mentioning

confidence: 99%

Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma

et al. 2023

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Oral squamous cell carcinoma (OSCC) is one of the most prevailing and aggressive head and neck cancers, featuring high morbidity and mortality. The available conventional treatments suffer from several adverse effects and are often inefficient in terms of their survival rates. Thus, seeking novel therapeutic agents and adjuvants is of the utmost importance for modern society. Natural polyphenolic compounds have recently emerged as promising chemopreventive and anticancer agents. Specifically, the natural compound resveratrol (RSV) has recently gained momentum for this purpose. RSV is useful for treating OSCC due to its antiproliferative, antimetastatic, and proapoptotic effects. Additionally, RSV acts against tumor cells while synergically cooperating with chemotherapeutics, overcoming drug resistance phenomena. Despite these wide-spectrum effects, there are few specific investigations regarding RSV’s effects against OSCC animal models that consider different routes and vehicles for the administration of RSV. Interestingly, an injectable RSV-loaded liposome-based formulation was proven to be effective against both in vitro and in vivo OSCC models, demonstrating that the development of RSV-loaded drug delivery systems for systemic and/or loco-regional applications may be the turning point in oral cancer treatment, leading to benefits from both RSV’s properties as well as from targeted delivery. Given these premises, this review offers a comprehensive overview of the in vitro and in vivo effects of RSV and its main derivative, polydatin (PD), against OSCC-related cell lines and animal models, aiming to guide the scientific community in regard to RSV and PD use in the treatment of oral precancerous and cancerous lesions.

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Section: Oral Squamous Cell Carcinoma (Oscc)mentioning

confidence: 99%

Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma

et al. 2023

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“…Each year, approximately 263,000 new cases are detected worldwide. Tragically, the disease claims the lives of 127,000 individuals annually ( 1 , 2 ). OSCC accounts for more than 90% of oral cancer ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Oral microbiota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms

Sukmana,

Saleh,

Najim

et al. 2024

Front. Oncol.

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Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer worldwide. Emerging research suggests a strong association between OSCC and the oral microbiota, a diverse community of bacteria, fungi, viruses, and archaea. Pathogenic bacteria, in particular Porphyromonas gingivalis and Fusobacterium nucleatum, have been closely linked to OSCC. Moreover, certain oral fungi, such as Candida albicans, and viruses, like the human papillomavirus, have also been implicated in OSCC. Despite these findings, the precise mechanisms through which the oral microbiota influences OSCC development remain unclear and necessitate further research. This paper provides a comprehensive overview of the oral microbiota and its relationship with OSCC and discusses potential carcinogenic pathways that the oral microbiota may activate or modulate are also discussed.

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“…The usual treatment for patients with early stage OSCC is surgery that can totally remove the tumors. The main clinical management for patients with advanced stage OCSS is diverse medical therapies i.e., radiotherapy, chemotherapy, immunotherapy, and combination therapy ( Nandini et al, 2020 ; Deshmukh et al, 2021 ). Although these medical therapies have been optimized over the last several decades, however, they are still far from ideal therapeutic efficacy ( Siegel et al, 2020 ; Surer et al, 2021 ) and the overall 5-year survival rate is less than 60% ( Yu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles as drug delivery systems in the treatment of oral squamous cell carcinoma: current status and recent progression

2023

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Oral squamous cell carcinoma (OSCC) is a common human malignancy with an estimated incidence of around 377,713 new cases worldwide in 2020. Despite the advance in clinical management, some of OSCC patients still miss the opportunity of completable resection of tumor, and have to accept medical therapies, e.g., chemotherapy, radiotherapy, or immunotherapy when the disease develops into the advanced stage. However, these therapies have been reported to be far from ideal due to the low efficiency of conventional delivery approaches. To obtain a better therapeutic effect, considerable attempts have been made toward to develop an effective drug delivery system (DDS). Nanoparticles (NPs) including inorganic NPs, polymer NPs, lipid NP, extracellular vesicles and cell membrane-based NPs have been evaluated as the better DDS candidates that can specifically accumulate in the tumor microenvironment along with a large amount of blood vessels. Emerging evidence suggested that NPs formulated with anticancer drugs including chemotherapeutic drugs, radiotherapy and immunotarget antibodies could remarkably improve the release and increase concentration of these drugs at the tumor site and show a better therapeutic efficacy, suggesting that NPs might serve as promising DDSs in the treatment of OSCC. Therefore, we have conducted this review to summarize recent progression and current status of diverse NPs as DDSs in this research field.

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Oral Squamous Cell Carcinoma: Diagnosis and Treatment Planning

Cited by 15 publications

References 32 publications

Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma

Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma

Oral microbiota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms

Nanoparticles as drug delivery systems in the treatment of oral squamous cell carcinoma: current status and recent progression

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