2018
DOI: 10.1080/20002297.2018.1476643
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Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

Abstract: Background: Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective: The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruses and xerostomia in patients with squamous cell carcinoma of head and neck submitted to radio/chemotherapy. Methods: In this study, oral rinse samples were collected weekly from 20 patients during radiotherapy. The … Show more

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Cited by 6 publications
(11 citation statements)
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References 37 publications
(43 reference statements)
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“…In the fourth week of RT, most of patients developed severe grades of dysphagia (grade ≥ 2) and they may only eat liquid food and may require tube feeding. 4,10,13,16,17,25 Similar findings were also observed in our study, where 50% of patients reported dysphagia in the first week of RT (25% with grade 1 and 25% with grade 3). Studies report that the severity of dysphagia may be associated with the cumulative dose of radiation, 12,17,26 -28 a finding corroborated by our study as this acute complication was more common and more severe along the weeks of RT.…”
Section: Discussionsupporting
confidence: 91%
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“…In the fourth week of RT, most of patients developed severe grades of dysphagia (grade ≥ 2) and they may only eat liquid food and may require tube feeding. 4,10,13,16,17,25 Similar findings were also observed in our study, where 50% of patients reported dysphagia in the first week of RT (25% with grade 1 and 25% with grade 3). Studies report that the severity of dysphagia may be associated with the cumulative dose of radiation, 12,17,26 -28 a finding corroborated by our study as this acute complication was more common and more severe along the weeks of RT.…”
Section: Discussionsupporting
confidence: 91%
“…15,16 The first stages of xerostomia are usually observed in the first weeks of RT. 4,10,13,16,21,23,24 In our group, 3 of 20 patients presented xerostomia in the first week and 9 of 20 in the second week of RT. A worsening of xerostomia occurred throughout the weeks of RT, with all patients (20/20) presenting some degree of xerostomia in the fourth week of RT as they had a reduction in their salivary flow rate.…”
Section: Discussionmentioning
confidence: 99%
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“…Two primers, HSVP1/P2 and VZVP1/P2, were designed to flank a well-conserved region of the DNA polymerase gene, based on an alignment of DNA sequences from the eight known human herpesviruses as described by Johnson et al in 2000 [ 24 ]. The positive samples were submitted to enzymatic digestion with BamHI and BstUI restriction enzymes (New England Biolabs) for specific determination of each one of the eight herpesviruses, also described in previous works of our group [ 25 27 ].…”
Section: Methodsmentioning
confidence: 99%