Cytokine Levels and Human Herpesviruses in Saliva from Clinical Periodontal Healthy Subjects with Peri-Implantitis: A Case-Control Study

Filho, Jaime S. Marques; Gobara, Jorge; Salomão, Gustavo Vargas da Silva; Sumita, Laura Masami; Shibli, Jamil Awad; Viana, Renato G.; Schwartz-Filho, Humberto Osvaldo; Pannuti, Cláudio Sérgio; Braz‐Silva, Paulo Henrique; Pallos, Débora

doi:10.1155/2018/6020625

Cited by 21 publications

(23 citation statements)

References 30 publications

(40 reference statements)

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“…A higher percentage of human herpes viruses were detected in saliva of subjects with Peri-implantitis [29]. HHV8 is detected in the saliva and the clinically healthy oral mucosa of HIV negative immune compromised cases.…”

Section: Discussionmentioning

confidence: 92%

PCR Detection of HHV8 DNA in the Saliva of Removable Denture Wearers Compared to Dentate Cases in Shiraz, South of Iran

Derafshi

Ghapanchi

Rezazadeh

et al. 2020

BioMed Research International

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Background and aim. Removable dentures may act as reservoir for pathogens that can cause serious infections. Human herpesvirus 8 (HHV8) is an oncogenic virus that was found in the saliva more than genital secretions. Thus, this study was designed to evaluate HHV8 in the saliva of patients with removable dentures. Method and material. In this cross-sectional study from March-July 2019, saliva samples were collected from 50 denture wearers as a case group and 50 ages and gender matched dentate subjects as a control. Whole-mouth saliva, parotid saliva, buccal, and palatal exfoliates were collected and processed for HHV8-DNA amplification by nested PCR. A confirmatory real-time PCR was also performed in order to prevent false result. Result. In the denture wearers, HHV8 DNA was detected in 11 cases. Two of the controls amplified HHV8 DNA. Fisher’s exact test demonstrates a significant difference between virus infection and using removable dentures (p=0.015). Conclusion. Our findings suggested that HHV8 detection could be associated with use of denture.

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Section: Discussionmentioning

confidence: 92%

PCR Detection of HHV8 DNA in the Saliva of Removable Denture Wearers Compared to Dentate Cases in Shiraz, South of Iran

Derafshi

Ghapanchi

Rezazadeh

et al. 2020

BioMed Research International

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“…Three of the included articles were cross-sectional studies [21,27,35] and the other two were case-control studies [19,34] (Table 1). The papers were published between 2011 and 2018.…”

Section: Study Methods and Characteristicsmentioning

confidence: 99%

“…Of these 14 articles, five were discarded after reading the titles and three after reading the abstract as they did not meet the inclusion criteria. Of the six full-text articles with potential for inclusion [18,19,21,27,34,35], one was excluded as it appeared to be the same study as another included paper but in earlier stage [18]. Finally, a total of five studies were included in the qualitative analysis [19,21,27,34,35] (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis

Roca-Millan

Domínguez-Mínger

Schemel-Suárez

et al. 2021

Viruses

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The exponential growth in the use of dental implants in the last decades has been accompanied by an increase in the prevalence of peri-implant disease. It appears that viruses may have pathogenic potential for the development of this pathology. The objective of this systematic review is to study the possible association between the presence of Epstein–Barr virus and the development of peri-implantitis. An electronic search was conducted in PubMed/MEDLINE, Scielo and Embase databases for cross-sectional and case–control studies in humans published up to and including 4 January 2021. Five studies were included in the qualitative analysis. The meta-analysis did not show a statistically significant difference regarding the prevalence of Epstein–Barr virus in the peri-implant sulcus between implants with peri-implantitis and healthy implants. In conclusion, no association between the human herpesvirus 4 and peri-implantitis was found. Further research on this topic is essential to develop more effective treatments.

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“…26 This composition allows the detection of pathogens in saliva and also the quantification of biomarkers that can provide information on the immunological, inflammatory, endocrine, and metabolic status of each individual. 27,28,29,30 Viral infections can be diagnosed in the saliva by directly targeting the genetic material of the virus (i.e. DNA or RNA) or indirectly, by searching for signatures left by these infections, such as proteins (proteomic analysis), metabolites (metabolomic analysis), miRNAs and other transcriptomic analyses and immunoglobulin profiles (IgA, IgG and IgM).…”

Section: Saliva-based Diagnosis and Screening Of Covid-19 In Childrenmentioning

confidence: 99%

Saliva: an important alternative for screening and monitoring of COVID-19 in children

et al. 2020

Self Cite

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The increasing number of cases of COVID-19 worldwide poses challenges to healthcare systems not only in effectively identifying individuals positive for SARS-CoV-2, but also in isolating cases to minimise contagion in early diagnosing more severe cases that will need hospitalization. Less-invasive collection methods are indispensable in a pandemic scenario as large-scale tests are necessary to understand the actual evolution of contagion in different populations, thus enabling decision-making based on scientific evidence. Saliva has been shown to be an alternative for diagnosing viral infections as this biological fluid can be easily and quickly collected without using specific devices and causing less discomfort during collection, which is an important factor for use in children. Despite the smaller percentage of severe cases of COVID-19 among children, they seem to play an important role in the contagion as they have the same potential of transmission as that of adults. Knowing the evolution of COVID-19 pandemic in children is extremely important, mainly regarding the changing in rules of social distancing, such as reopening schools and recreational activities spaces. In addition, countless cases of a severe multi-systemic inflammatory syndrome that shares clinical and laboratory features with Kawasaki's disease have been recently related to SARS-CoV-2 infections in children, adolescents and young adults. In view of this scenario, the aim of this study was to present saliva as an alternative for seeking diagnostic and prognostic markers of COVID-19 in children, including adequate sample collection techniques for different age groups.

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Cytokine Levels and Human Herpesviruses in Saliva from Clinical Periodontal Healthy Subjects with Peri-Implantitis: A Case-Control Study

Cited by 21 publications

References 30 publications

PCR Detection of HHV8 DNA in the Saliva of Removable Denture Wearers Compared to Dentate Cases in Shiraz, South of Iran

PCR Detection of HHV8 DNA in the Saliva of Removable Denture Wearers Compared to Dentate Cases in Shiraz, South of Iran

Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis

Saliva: an important alternative for screening and monitoring of COVID-19 in children

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