Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program

Batista-Jorge, Gislaine Cândida; Barcala-Jorge, Antônio Sérgio; Silveira, Marise Fagundes; Lelis, Deborah Farias; Andrade, João Marcus Oliveira; Paula, Alfredo Maurício Batista de; Guimarães, André L. S.; Santos, Sérgio Henrique Sousa

doi:10.1016/j.lfs.2020.117962

Cited by 33 publications

(31 citation statements)

References 51 publications

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“…Based on DSLD data, a number of the reviewed compounds are available in OTC supplements: the alkaloid BBR; the carboxylic acid derivatives cinnamic acid and ferulic acid; the carotenoids astaxanthin and crocetin; the coumarin osthole; curcumin; the flavonoids diosmin, EGCG, naringin, quercetin, resveratrol, chrysin, and rutin; the lignan magnolol; the natural steroids withaferin A and diosgenin; and the terpenes betulinic acid and paeoniflorin. Many of these supplements exert positive physiological effects; in particular, astaxanthin and curcumin positively influence the central nervous system [ 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ].…”

Section: Implications For Lifestyle Medicinementioning

confidence: 99%

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Zhai

Siddiqui

Abdellatif

et al. 2021

Cancers

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Glioblastoma (GBM) is an aggressive, often fatal astrocyte-derived tumor of the central nervous system. Conventional medical and surgical interventions have greatly improved survival rates; however, tumor heterogeneity, invasiveness, and chemotherapeutic resistance continue to pose clinical challenges. As such, dietary natural substances—an integral component of the lifestyle medicine approach to chronic diseases—are examined as potential chemotherapeutic agents. These heterogenous substances exert anti-GBM effects by upregulating apoptosis and autophagy, inducing cell cycle arrest, interfering with tumor metabolism, and inhibiting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis. Although these beneficial effects are promising, natural substances’ efficacy in GBM is constrained by their bioavailability and blood–brain barrier permeability; various chemical formulations are proposed to improve their pharmacological properties. Many of the reviewed substances are available as over-the-counter dietary supplements, underscoring their viability as lifestyle interventions. However, clinical trials remain necessary to substantiate the in vitro and in vivo properties of natural substances.

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Section: Implications For Lifestyle Medicinementioning

confidence: 99%

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Zhai

Siddiqui

Abdellatif

et al. 2021

Cancers

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“…have shown a variety of effects against subjects with MetS features, often with limited or even controversial results. [48][49][50][51] Although some trials with polyphenol-derived products have recruited some medicated MetS patients, [52,53] in general, the component "under drug therapy" has not been sufficiently addressed since either it is usually present in the exclusion criteria of the protocols or the statistical analyses do not include the type of medication as a crucial variable.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial

Cortés‐Martín

Iglesias‐Aguirre

Meoro

et al. 2021

Molecular Nutrition Food Res

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Scope Poly‐pharmacological therapy shapes the gut microbiota (GM) in metabolic syndrome (MetS) patients. The effects of polyphenols in poly‐medicated MetS patients are unknown. Methods and results A randomized, placebo‐controlled, double‐blinded, and crossover trial in poly‐medicated MetS patients (n=50) explored whether the effects of a pomegranate extract nutraceutical (PE, 320 mg phenolics/day for 1 month) are affected by the drug therapy. Considering the lipid‐lowering (LL‐), anti‐hypertensive (HP‐) and(or) anti‐diabetic (AD‐) treatments: GM (16S rRNA sequencing), short‐chain fatty acids, 40 inflammatory‐metabolic and endotoxemia‐related biomarkers, associations between biomarkers and GM with 53 cardiometabolic dysfunctions‐related single‐nucleotide polymorphisms (SNPs), and urolithin metabotypes (UMs) influence are evaluated. Representative SNPs‐GM associations after PE include Lactococcus and ClostridiumXIVa with rs5443‐GNB3 (G‐protein‐β‐polypeptide‐3) and ClostridiumXIVa with rs7903146‐TCF7L2 (transcription‐factor‐7‐like‐2) and rs1137101‐LEPR (leptin‐receptor). PE decreases sICAM‐1 in LL‐patients and the lipopolysaccharide‐binding protein in all the patients. PE does not affect the other patients’ markers as a group or stratifying by UMs. After PE, Lactococcus increases in AD‐, LL‐, and HP‐patients, Bifidobacterium increases in LL‐ and AD‐, while Clostridium XIVa decreases in non‐LL‐ and non‐HP‐patients. Conclusion The prebiotic effect of PE depends on the medication, mainly on HP‐treatments. Targeting GM can complement MetS therapy, but the patients’ drug therapy should be considered individually.

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“…For these reasons, interest in new approaches, such as the use of nutraceuticals, is growing. Among these, resveratrol has aroused much interest due to its multiple beneficial effects reported in humans [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Resveratrol Administration in Human Obesity

Mongioì

Vignera

Cannarella

et al. 2021

IJMS

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Obesity is a widespread disease that is associated with numerous and serious comorbidities. These include metabolic syndrome, diabetes mellitus, cardiovascular-cerebrovascular disease, hypertension, obstructive sleep apnea syndrome, cancer, and sexual and hormonal disorders. The treatment of obesity has therefore become a goal of great clinical and social relevance. Among the therapeutic strategies against obesity, resveratrol has aroused great interest. This polyphenol has anticancer and antioxidant properties and cytoprotective and anti-inflammatory effects. Other favorable effects attributed to resveratrol are anti-lipid, anti-aging, anti-bacterial, anti-viral, and neuroprotective actions. Administration of resveratrol appears to improve the metabolic profile in obese and/or insulin-resistant patients. This article aims to review the main results of clinical studies evaluating the effects of administering resveratrol alone in overweight/obese patients.

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Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program

Cited by 33 publications

References 51 publications

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial

The Role of Resveratrol Administration in Human Obesity

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