2001
DOI: 10.1111/j.1574-695x.2001.tb01549.x
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Oral probiotics can resolve urogenital infections

Abstract: We report the first clinical evidence that probiotic lactobacilli can be delivered to the vagina following oral intake. In 10 women with a history of recurrent yeast vaginitis, bacterial vaginosis (BV) and urinary tract infections, strains Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14 suspended in skim milk and given twice daily for 14 days, were recovered from the vagina and identified by morphology and molecular typing within 1 week of commencement of therapy. In six cases of asymptomatic BV… Show more

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Cited by 368 publications
(166 citation statements)
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“…Probiotics mechanisms of action vary, however, some are known to produce various antimicrobial agents such as organic acids, hydrogen peroxide, carbon peroxide, diacetyl, low molecular weight antimicrobial substances and bacteriocins (Merk et al, 2005). In addition, probiotics have long been known also for the capacity to interfere with the adhesion and formation of biofilms of pathogens to epithelial cells of urogenital and intestinal tracts (Reid et al, 1998(Reid et al, , 2001). The mechanisms of this interference include the release of surface active molecules (Gudiña et al, 2010;Rodrigues et al, 2006d).…”
Section: Probiotics Biosurfactants Activitymentioning
confidence: 99%
“…Probiotics mechanisms of action vary, however, some are known to produce various antimicrobial agents such as organic acids, hydrogen peroxide, carbon peroxide, diacetyl, low molecular weight antimicrobial substances and bacteriocins (Merk et al, 2005). In addition, probiotics have long been known also for the capacity to interfere with the adhesion and formation of biofilms of pathogens to epithelial cells of urogenital and intestinal tracts (Reid et al, 1998(Reid et al, , 2001). The mechanisms of this interference include the release of surface active molecules (Gudiña et al, 2010;Rodrigues et al, 2006d).…”
Section: Probiotics Biosurfactants Activitymentioning
confidence: 99%
“…Установлено, что способность лактобацилл к формированию биопленок зависит от свойств штам-ма, его концентрации, а также физико-химических свойств среды [12,13]. Более двух десятилетий назад выявили, что лактобациллы прямой кишки являют-ся источником колонизации влагалища [14], и этот факт был подтвержден более поздними исследова-ниями [15,16]. Конечно, способность к перемеще-нию из прямой кишки присуща не только отдельным штаммам лактобацилл, но и другим микроорганиз-мам желудочно-кишечного тракта, имеющим специ-фический вагинальный тропизм [17].…”
Section: Discussionunclassified
“…Probiotics (L. rhamnosus GR-1 and L. fermentum RC-14) are considered to have theraupetic benefits in vaginosis. Probably this is due to the large numbers of lactobacilli in the healthy vaginal microflora [72,73]. c. Other ailments.…”
Section: Other Disordersmentioning
confidence: 99%