Oral potentially malignant disorders: Revisited

Ray, Jharna

doi:10.4103/jomfp.jomfp_224_17

Cited by 15 publications

(10 citation statements)

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“…European physicians originally introduced OPMDs in 1805 as “pre-cancer,” suggesting that oral pre-cancers are benign conditions that may eventually develop into invasive malignancies in the long run ( Ray, 2017 ). Thereafter, constant efforts were made to characterize and define the term oral pre-cancerous conditions, and in 1978 the WHO proposed the terms “pre-cancerous conditions” and “pre-cancerous lesion.” Later, the WHO merged the term lesions and condition to represent all the clinical manifestations that carry a risk to oral cancer as “oral potentially malignant disorders” (OPMDs) ( Table 1 ) ( Van der Waal, 2019 ).…”

Section: Oral Potentially Malignant Disordersmentioning

confidence: 99%

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

2022

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Section: Oral Potentially Malignant Disordersmentioning

confidence: 99%

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

2022

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“…[ 2 ] As per World Health Organization (WHO), oral potentially malignant disorders (OPMDs) are the lesions with morphologically altered tissue having higher likelihood to progress to oral cancer. [ 3 ] The common subtypes of OPMDs include leukoplakia, erythroplakia, oral submucus fibrosis (OSMF), lichen planus, and oral ulcers.…”

Section: Introductionmentioning

confidence: 99%

Association of micronuclear frequency with dysplasia and cytogenetic changes (p53 mutation and p16 expression) in oral potentially malignant disorders

Tammewar

Gadkari

2022

J Cytol

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Aims: The present study evaluated the frequency of micronuclei in oral potentially malignant disorders (OPMDs) and their association with the presence of dysplasia on cytology and biopsy as well as their association with p53 mutation and p16 expression. Cytological findings of dysplastic changes in OPMDs were compared to histological diagnoses. Material and Methods: This was a cross-sectional, observational, descriptive study. Scrape smears ( n = 74) were collected from lesions in patients with OPMDs. Punch biopsy was collected in patients showing dysplastic changes. Tissue microarray for p53 mutation and p16 expression was performed using paraffin embedded blocks. Cases were classified into grades of dysplasia using both scrape smears and biopsy. Micronuclei frequency was calculated per 100 cells using scrape smears. Mann–Whitney U test was used for correlation of cytology and histology for grade of dysplasia as well as micronuclear frequency with p53 mutation and p16 expression. Results: Micronuclear frequency was found to be increased in patients with dysplasia. A significant association of micronuclear frequency with dysplastic changes was seen on cytology. Sensitivity of cytological evaluation was found to be 64.7%. The association of the micronuclear frequency of samples with p53 mutation and p16 expression was nearly significant (n = 28, P = 0.069 and 0.095, respectively). Conclusion: Micronuclear frequency can be a reliable marker of mutagenic change in OPMDs. Cytological assessment of micronuclei can serve as useful, non-invasive, and relatively inexpensive tool to predict cancerous changes in OPMDs.

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“…Some lesions can precede oral cancer and are called oral potentially malignant disorders, however, not all potentially malignant disorders progress to cancer, and not all cancer originates from them. In 2005, the WHO recommended abandoning of the terminology premalignant and instead proposed to use the term 'oral potentially malignant disorders' (OPMDs) [5].…”

Section: Introductionmentioning

confidence: 99%

Histopathological diagnosis of oral lesions at a Pathology Institute in Brazil

Zimmer

Garbin

Vogel

et al. 2022

Preprint

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Background: This study analyzed the most prevalent diagnoses of oral lesions submitted to biopsy using data from a pathology laboratory and associations between malignant and oral potentially malignant disorders with patient’s demographic variables and the anatomical location. Methods: This is a cross-sectional study. All 1,298 histopathological reports of oral lesions recorded in the database of the Institute of Pathology were reviewed. Demographic variables, anatomical location of the lesion, histopathological diagnosis of the lesions and their biological behavior were analyzed using a logistic regression. Results: Regarding the biological behavior of the identified lesions, benign lesions were predominant (70%), followed by lesions of undetermined behavior (14.3%), malignant lesions (14.2%), absence of histological alteration in the sample (1.2%), and finally, oral potentially malignant disorders (0.5%). The anatomical locations of the most prevalent oral lesions potentially malignant disorders and malignant were in the following structures of the oral cavity: gums, roof of the mouth, floor of the mouth, inner lining of the cheeks (P=49.2%), and tongue (P=48.7%). In the final adjusted model, the probability of malignant and premalignant lesions was higher among males (PR= 4.21; 95% CI 2.08-6.22), the increase in age (PR = 1.06; 95% CI 1, 05-1.08), and in the tongue region (PR = 5.48; 95% CI 1.67; 17.92). Conclusion: This study suggests that the probability of identifying malignant and oral potentially malignant disorders is higher in males whit age advanced and specimens from the tongue.

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Oral potentially malignant disorders: Revisited

Cited by 15 publications

References 0 publications

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

Association of micronuclear frequency with dysplasia and cytogenetic changes (p53 mutation and p16 expression) in oral potentially malignant disorders

Histopathological diagnosis of oral lesions at a Pathology Institute in Brazil

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