Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

Kumari, Pratima; Debta, Priyanka; Dixit, Anshuman

doi:10.3389/fphar.2022.825266

Cited by 69 publications

(41 citation statements)

References 193 publications

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“…This disturbance could be caused by a lack of moisture in the mucosa or a defect in the lubrication function of saliva, which may be related to mucin glycosylation 25 . Chronic inflammatory infiltrates in the oral cavity may also lead to mutations in the epithelium and further increase the risk of cancer development 26 …”

Section: Discussionmentioning

confidence: 99%

Increased prevalences of head and neck cancers in patients with Sjögren's syndrome

Yang,

Cheng,

Chen

et al. 2023

Head & Neck

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ObjectiveThis study aimed to investigate prevalences of head and neck cancers in patients with and those without Sjögren's syndrome using a population‐based dataset.MethodsWe retrieved sampled patients from Taiwan's Longitudinal Health Insurance Database. This study included 38 930 patients with Sjögren's syndrome and 155 720 propensity‐score matched comparison patients without Sjögren's syndrome.ResultsChi‐squared tests revealed that there was a statistically significant difference in the prevalences of head and neck cancers between patients with Sjögren's syndrome and comparison patients (1.77% vs. 1.22%, p < 0.001). The odds ratio for head and neck cancers for patients with Sjögren's syndrome relative to the comparison group was 1.452 (95% CI = 1.325–1.592).ConclusionsOur study demonstrated that patients with Sjögren's syndrome face increased odds of head and neck cancers, encompassing several sites including the oral cavity, oropharynx, nasopharynx, and thyroid.

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Section: Discussionmentioning

confidence: 99%

Increased prevalences of head and neck cancers in patients with Sjögren's syndrome

Yang,

Cheng,

Chen

et al. 2023

Head & Neck

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“…These cells are physically present and actively recognize the antigen and attack the target, which is a slower process [21]. These diseases are generally associated with a higher risk of developing HNC, as the chronic inflammation and tissue damage caused by these diseases can create a favorable environment for the development of malignant changes [22]. GVHD especially, which is related to hematopoietic stem cell transplantation, has been associated with the development of malignancies, namely oral carcinoma [23][24][25][26][27].…”

Section: Cell-mediated Inflammatory Diseasesmentioning

confidence: 99%

Systemic Inflammatory Disorders, Immunosuppressive Treatment and Increase Risk of Head and Neck Cancers—A Narrative Review of Potential Physiopathological and Biological Mechanisms

Vale,

Pereira,

Mendes

2023

Cells

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Head and neck cancers (HNCs) are known to present multiple factors likely to influence their development. This review aims to provide a comprehensive overview of the current scientific literature on the interplay between systemic inflammatory disorders, immunosuppressive treatments and their synergistic effect on HNC risk. Both cell-mediated and humoral-mediated systemic inflammatory disorders involve dysregulated immune responses and chronic inflammation and these inflammatory conditions have been associated with an increased risk of HNC development, primarily in the head and neck region. Likewise, the interaction between systemic inflammatory disorders and immunosuppressive treatments appears to amplify the risk of HNC development, as chronic inflammation fosters a tumor-promoting microenvironment, while immunosuppressive therapies further compromise immune surveillance and anti-tumor immune responses. Understanding the molecular and cellular mechanisms underlying this interaction is crucial for developing targeted prevention strategies and therapeutic interventions. Additionally, the emerging field of immunotherapy provides potential avenues for managing HNCs associated with systemic inflammatory disorders, but further research is needed to determine its efficacy and safety in this specific context. Future studies are warranted to elucidate the underlying mechanisms and optimize preventive strategies and therapeutic interventions.

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“…Transformation of normal oral mucosa into OSCC involves multiple steps, of which oral potentially malignant disorders (OPMDs) have received increasing attention owing to the high risk of malignant transformation (the overall malignant conversion rate is 7.9% [13]). More than 80% of oral cancer cases develop from OPMDs [14]. Common OPMDs with a high risk of transformation include oral leukoplakia, proliferative verrucous leukoplakia, erythroplakia, oral lichen planus (OLP), and oral submucous fibrosis.…”

Section: Oral Microbiota Participating In the Occurrence Development ...mentioning

confidence: 99%

Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma

Wang,

Gao

2023

Current Oncology

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Microorganisms in the oral cavity are abundant in the human body. At present, more than 700 species of oral microorganisms have been identified. Recently, a lot of literature has indicated that the oral microbiota plays an important role in the occurrence, development, and prognosis of oral squamous cell carcinoma (OSCC) through various mechanisms. And researchers are now trying to utilize oral microbiota in cancer diagnosis and treatment. However, few articles systematically summarize the effects of oral microbes in the diagnosis, treatment, and disease outcomes of oral cancer. Herein, we made a summary of the microbial changes at cancerous sites and placed more emphasis on the mechanisms by which the oral microbiome promotes cancerization. Moreover, we aimed to find out the clinical value of the oral microbiome in OSCC.

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Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer

Cited by 69 publications

References 193 publications

Increased prevalences of head and neck cancers in patients with Sjögren's syndrome

Increased prevalences of head and neck cancers in patients with Sjögren's syndrome

Systemic Inflammatory Disorders, Immunosuppressive Treatment and Increase Risk of Head and Neck Cancers—A Narrative Review of Potential Physiopathological and Biological Mechanisms

Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma

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