Oral peripheral ameloblastoma: A retrospective series study of 25 cases

Abstract

BackgroundPeripheral ameloblastoma (PA) is a rare and unusual variant of odontogenic tumor, which was described only in isolated case reports in literature. The objective of this study was to investigate the clinical profile, treatment and outcome of PA in a consecutive case series.Material and MethodsA total of 25 patients with histologically confirmed PA from 2001 to 2015 were retrospectively reviewed in our institution.ResultsOf the 25 patients, 22 males and 3 females were identified (male: female = 7.3:1). The average age was 48.3 years (range 11-81 years) with lingual or palate gingival region being the most common site (76%). The course of disease was less than 6 months in 92.0% (23/25) of all patients (mean, 3.3 months; range, 1-12 months). All patients underwent complete surgical removal of the lesions, and one lesion recurrence occurred during the follow-up period.ConclusionsThe clinical profile and outcome of PA from Eastern China were elucidated in this retrospective analysis based on a case series. Our experience may provide some insights into the differential diagnosis and clinical management of PA. The first choice of treatment is surgical excision, which can result in a good prognosis. Key words:Peripheral ameloblastoma, clinical profile, outcome.

Peripheral ameloblastoma of the gingiva

“…In 1959 Stanley and Krogh took the privilege of documenting the first case of peripheral ameloblastoma. 6 PA predominantly occurs in the gingiva and also named as "Gingival ameloblastoma". 7 Though, PA is an indolent tumor with the recurrence rate 16-19%; their recurrence as ameloblastic carcinomas, makes the follow up mandatory.…”

Recurrent peripheral ameloblastoma in an elderly patient: A case report

“…It is an uncommon type of ameloblastoma, accounting for 1%‐10% of the cases . Approximately, only 235 cases of PA have been previously reported in the English‐language literature …”

“…PA usually presents as a sessile and painless nodule located in the gingiva or alveolar mucosa of edentulous areas, especially in the mandible . Although some extragingival cases have been reported, the correct definition of PA exclude these locations .…”

“…The most common hypotheses are fibrous hyperplasia, pyogenic granuloma, ossifying fibroma, peripheral giant cell granuloma and benign tumours. In denture‐wearing patients, a condition seen especially in the elderly, the main diagnosis hypothesis is often a denture‐related inflammatory fibrous hyperplasia …”

“…PA commonly presents as a nodule located in the gingiva or alveolar mucosa of edentulous areas, especially in the mandible . Its main clinical differential diagnosis are common reactive hyperplastic lesions of the oral mucosa, such as denture‐related inflammatory fibrous hyperplasia and pyogenic granuloma . An important feature of this lesion is its incidence in a higher age range when compared to intraosseous ameloblastomas .…”