Oral Papillomatosis in a Dog and its Therapy with Taurolidine

Abstract

Biricik H.S., M. Cabalar, M.Y. Gulbahar: Oral Papillomatosis in a Dog and its Therapy with Taurolidine. Acta Vet. Brno 2008, 77: 373-375.The efficacy of taurolidine on the treatment of oral papillomatosis in a 1-year-old Turkish Kangal dog was evaluated. Diagnosis of the papillomatosis was based on clinical signs, histopathological and immunohistochemical examinations. The dog received 45 mg/kg taurolidine intravenously every 3 days. Regression of papillomas started to be observed after the beginning of treatment, and complete resolution occurred after the fifth application. Papillomatosis, taurolidine, dogOral papillomatosis is seen more commonly in young dogs, and warts usually begin on the lips and may spread to the buccal mucosa, tongue, palate, and pharynx. It is characterized by multiple papillomas in the oral cavity. The lesions occasionally become extensive, requiring veterinary attention (Bredal et al. 1996;Fenner et al. 1993). Furthermore, with the increasing number of papillomas, food consumption may become a problem.Taurolidine is a novel antimicrobial agent for local or parenteral use. It has a unique spectrum of antimicrobial activity, including gram negative and positive bacteria and fungi (Blenkharn 1988). It has been used extensively for its antimicrobial and antiendotoxemic properties, particularly in peritonitis (McCourt et al. 2000). Taurolidine also appears to possess immunoregulatory properties, reducing tumour growth and spread (Nici et al. 2004).Experimental studies proved that the systemic administration of taurolidine solution is well tolerated (Johnston et al. 1993;Torres-Viera et al. 2000). According to veterinary literature, no research was conducted to establish whether systemic administration of taurolidine influences oral papillomatosis. We hypothesized that taurolidine may have an effect on oral papillomatosis. Our aim was to examine the therapeutic effectiveness of taurolidine against canine oral papillomatosis. Materials and MethodsA 1-year-old Turkish Kangal dog was presented with severe papillomatous growths protruding from the oral mucous membranes (Plate X, Fig. 1). Wart-like growths were seen as reminiscent of a cauliflower in or around the mouth, buccal mucosa, tongue and gingiva. The dog had such a large number of papillomas that consuming food became a problem.A tentative diagnosis of canine oral papillomavirus (PV) infection was made on the gross appearance of the numerous lesions. Two warts from the oral mucosa were removed surgically for further diagnostic investigations. The diagnosis was established by histological examination in association with immunohistochemical analysis.Wart specimens were fixed in 10% neutral-buffered formalin solution, and then embedded in paraffin following the routine processing. Five-µm-thick sections obtained from the paraffin blocks were stained with haematoxylineosin. For immunohistochemistry, sections were prepared using a commercial avidin-biotin peroxidase complex (ABPC) kit (Zymed Laboratories, Inc., CA). Firstly, deparaffi...

Therapeutic evaluation of homeopathic treatment for canine oral papillomatosis

“…Various therapeutic regimes were used to alleviate COP. External application of apple cider vinegar, pod wart, and petroleum jelly [9] Thuja occidentalis [24], imiquimod, and 5-fluorouracil [8]; oral administration of levamisole [3], cimetidine [25], interferon alfa [7], human recombinant interferon-α 2a [26], T. occidentalis [27], acyclovir [28], etretinate [7], and azithromycin [23]; subcutaneous injection of tarantula cubenis extract [29], feline recombinant interferon-ω [30], autogenous vaccine [31], and T. occidentalis [32]; intramuscular injection of lithium antimony thiomalate [9]; intramuscular injection of Propionibacterium acnes [33]; intralesional administration of interferon alfa [7]; and intravenous injection of vincristine sulfate and immunoregulin [31], and taurolidine [3] were reported. Injectable interferon directly stimulates the immune system thereby helps to resolve warts.…”

“…Autogenous vaccine and immune modulation drugs such as levamisole and thiabendazole are used but proof for their efficiency is lacking [7]. Systemic or local chemotherapy drugs such as vincristine, vinblastine, cyclophosphamide, methotrexate, chlorambucil, and doxorobucin lead to inefficient or controversial results in the majority of papilloma cases, with longer duration of the treatment period and varying degrees of success [3,34].…”

“…Canine oral papillomatosis (COP) is the most common, self-limiting neoplastic disease of dogs caused by canine oral papillomavirus (COPV). Dogs of <4 years old are commonly affected and there is no difference in the prevalence of COP among different breeds of dogs with no gender predisposition [3]. COP is characterized by high morbidity and low mortality with good prognosis, and animal stays immune for the rest of life [4].…”

Tarantula cubensis extract (Theranekron®) ınhibits ınflammation in carrageenan-ınduced acute paw edema in rats

“…Today research focuses on finding anti-inflammatory agents with selective pharmacological effects and less toxicity (Lee et al, 2001;Picolo et al, 2000;Sadeghi et al, 2013;Viji and Helen, 2008). Theranekron ® (TCAE) is an alcoholic extract of the venom of Tarantula cubensis which remains active in pharmaceutical compounds for a considerable time and has been used to treat a wide variety of conditions ranging from tumors to abscesses, septicemia, and toxemic injuries (Albay et al, 2010;Biricik et al, 2008;Cam et al, 2007;Gultiken and Vural, 2007;Kaçar et al, 2007;Lotfollahzadeh et al, 2012;Oryan et al, 2012;Sardari et al, 2007;Stampa, 1986). Sardari et al (2007) claimed that TCAE reduces inflammation and stimulates re-epithelialization of the full-thickness cutaneous wounds in cows during the first 14 days after injury.…”

Papilomatose canina

“…Um outro relato defende também o uso de taurolide a cada 3 dias em casos de infecção por papilomavírus oral canino 20 .…”