Oral Ondansetron in Management of Dehydrating Diarrhea with Vomiting in Children Aged 3 Months to 5 Years: A Randomized Controlled Trial

Systematic review with meta‐analysis: ondansetron for vomiting in children with acute gastroenteritis

“…In addition to the previously identified four RCTs, six new RCTs were included . In addition, six registered trials were identified.…”

“…All included trials were placebo‐controlled and full peer‐reviewed publications. The trials were conducted in countries such as India, Iran, Thailand, Turkey, USA and Venezuela . Two trials were carried out in hospitalised patients; and the remaining trials in emergency departments.…”

“…Altogether, 1215 participants, 609 in the experimental group and 606 in the control group, were randomised. The sample sizes ranged from 24 to 214 participants; of note, sample size calculations were available in four trials only . In most of the RTCs, the age of participants varied from 3 months to 15 years; only in one RTC was the age of patients 1 month to 22 years …”

“…Follow‐up ranged from 4 h to 7 days. The definitions of outcomes, as well as the assessment of the degree of dehydration, varied as the used scales were different and some authors did not mention the degree of dehydration at all …”

Ondansetron as the first approach in the management of the patients with acute gastroenteritis visiting the pediatric emergency department: A single-center experience

“…To the Editor, It has been recently shown that a single oral dose of ondansetron, given before starting oral rehydration therapy (ORT), in children aged 3 months to 5 years with diarrhea and vomiting resulted in better oral rehydration without significant adverse events (1). We retrospectively evaluated ondansetron use in our pediatric emergency department between May and June 2015.…”