Single-dose of ondansetron for vomiting in children and adolescents with acute gastroenteritis—an updated systematic review and meta-analysis

Fugetto, Francesco; Filice, Emanuele; Biagi, Carlotta; Pierantoni, Luca; Gori, Davide; Lanari, Marcello

doi:10.1007/s00431-020-03653-0

Cited by 11 publications

(5 citation statements)

References 34 publications

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“…Oral rehydration solutions are recommended, while antibiotics and anti-diarrheal medications are discouraged, aligning with international guidelines [ 27 ]. In the Netherlands, the recommended single dose of oral ondansetron is 0.1 mg/kg, while Australia advises a higher single dosage regimen [8-15kg 2mg; 15-30kg 4mg; >30kg 6-8mg] [ 19 , 28 ] consistent with previous research [ 29 , 30 ]. The lower dosage strategy in the Netherlands is based on a more recent randomized controlled trial that found [cost-]effectiveness at a lower dosage [ 31 , 32 ].…”

Section: Discussionsupporting

confidence: 78%

Comparing healthcare systems between the Netherlands and Australia in management for children with acute gastroenteritis

Weghorst,

Sanci,

Berger

et al. 2024

PLoS ONE

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Background Acute gastroenteritis is a highly contagious disease demanding effective public health and clinical care systems for prevention and early intervention to avoid outbreaks and symptom deterioration. The Netherlands and Australia are both top-performing, high-income countries where general practitioners (GPs) act as healthcare gatekeepers. However, there is a lower annual incidence and per-case costs for childhood gastroenteritis in Australia. Understanding the systems and policies in different countries can lead to improvements in processes and care. Therefore, we aimed to compare public health systems and clinical care for children with acute gastroenteritis in both countries. Methods A cross-country expert study was conducted for the Netherlands and Australia. Using the Health System Performance Assessment framework and discussions within the research group, two questionnaires (public health and clinical care) were developed. Questionnaires were delivered to local experts in the Netherlands and the state of Victoria, Australia. Data synthesis employed a narrative approach with constant comparison. Results In Australia, rotavirus vaccination is implemented in a national program with immunisation requirements and legislation for prevention, which is not the case in the Netherlands. Access to care differs, as Dutch children must visit their regular GP before the hospital, while in Australia, children have multiple options and can go directly to hospital. Funding varies, with the Netherlands providing fully funded healthcare for children, whilst in Australia it depends on which GP (co-payment required or not) and hospital (public or private) they visit. Additionally, the guideline-recommended dosage of the antiemetic ondansetron is lower in the Netherlands. Conclusions Healthcare approaches for managing childhood gastroenteritis differ between the Netherlands and Australia. The lower annual incidence and per-case costs for childhood gastroenteritis in Australia cannot solely be explained by the differences in healthcare system functions. Nevertheless, Australia’s robust public health system, characterized by legislation for vaccinations and quarantine, and the Netherland’s well-established clinical care system, featuring fully funded continuity of care and lower ondansetron dosages, offer opportunities for enhancing healthcare in both countries.

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Section: Discussionsupporting

confidence: 78%

Comparing healthcare systems between the Netherlands and Australia in management for children with acute gastroenteritis

Weghorst,

Sanci,

Berger

et al. 2024

PLoS ONE

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“…This indicates a significant positive impact of applying the acupressure (p =.0001). **highly statistical significance differences Table (5) displays a comparison of the study and control groups' overall mean Rhodes scale scores for nausea and vomiting at 12-hour intervals over the 48-hour period that follows the delivery of chemotherapy. Using the Mann-Whitney test, there was a very significant drop in the mean scores beginning after the first twelve-hour period and continuing until the end of forty-eight hours after the administration of chemotherapy (p =.0001).…”

Section: Discussionmentioning

confidence: 99%

“…It kills cancer cells in three stages: induction of remission, consolidation (or intensification), and maintenance (or continuation) therapies; it also includes prophylactic treatment for the central nervous system and relapse management. Regrettably, chemotherapy has adverse consequences in addition to its therapeutic benefits, as nausea as well as vomiting (ZEKRI, et al, 2016) & (Fugetto, et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effect of Acupressure on Nausea and Vomiting among Children with Leukemia

Abolwafa,

Hasan,

Shehata

2024

Minia Scientific Nursing Journal

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Background: One non-pharmacological technique that has been successful in lowering the frequency of vomiting in children with leukemia is acupressure. Aim: This study aimed to evaluate the effect of acupressure on nausea and vomiting among children with leukemia. Method: A quasi-experimental (pretest/ posttest) research design was used. Setting: The study will be conducted at Minia Oncology Centre. Sample: (80 children) were randomly assigned to either study or control groups at the Minia Oncology Centre over the period of 6 months period. Tools: One tool was used to collect data including two parts (I) A demographic as well as clinical data interview questionnaire. Part (II) Rhodes scale for Nausea as well as Vomiting. Results: In comparison to the control group, the applying of acupressure in children with acute leukemia undergoing chemotherapy resulted in a highly statistically significant reduction (P.value 0.0001) in the frequency, distress, and severity of nausea as well as in the duration, frequency, as well as severity of vomiting through forty eight hours of the start administration of chemotherapy. Conclusion: Acupressure must be performed as a supportive nursing intervention to minimize Chemotherapy-induced nausea as well as vomiting (CINV) in children with leukemia. Recommendations: Acupressure may be suggested as a useful, nonpharmacologic treatment for nausea and vomiting brought on by leukemia-related chemotherapy.

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“…Seeing as the primary goal of AGE management is the prevention/correction of dehydration, the use of antiemetics could be considered in children older than 6 months of age for the reduction of dehydration due to vomiting. Available studies support the use of a single dose of ondansetron in paediatric AGE and report its efficacy in reducing the failure of oral rehydration therapy and the subsequent need for IV rehydration, in addition to reducing hospitalisation rates [ 54 ]. While evidence remains of relatively low quality, ondansetron was the only antiemetic that proved safe and effective in paediatric AGE [ 55 ] and is the only antiemetic recommended or considered in international guidelines [ 15 , 26 ].…”

Section: Management Of Agementioning

confidence: 99%

National Consensus for the Management of Acute Gastroenteritis in Jordanian Children: Consensus Recommendations Endorsed by the Jordanian Paediatric Society

Rawashdeh

Al-Zoubi²,

Barbar

et al. 2022

International Journal of Pediatrics

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Diarrhoeal diseases are one of the leading worldwide preventable causes of death among children under 5 years of age. Almost half of children do not receive optimal acute gastroenteritis (AGE) treatment in Jordan. With neither regional nor local guidelines available for AGE, consensus recommendations on the management of paediatric AGE in Jordan were developed by a panel of senior paediatricians and paediatric gastroenterologists and are endorsed by the Jordanian Paediatric Society. Recommendations are based on international guidelines and available relevant literature in relation to the AGE landscape and the healthcare system in Jordan. The prevention of diarrhoeal diseases should focus on the improvement of nutrition, hygiene, and sanitation, the introduction of routine vaccination against rotavirus, and the adoption of a standardised approach for AGE management (oral rehydration solution (ORS) use±adjunct therapies, continued feeding, and avoiding routine antibiotic use). Ondansetron, diosmectite, racecadotril, probiotics, and zinc can be considered adjunct to ORS, if needed. Local data gaps should be addressed. The clinical algorithm for the management of paediatric AGE could promote adherence to practice recommendations and by extension improve health outcomes in children.

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Single-dose of ondansetron for vomiting in children and adolescents with acute gastroenteritis—an updated systematic review and meta-analysis

Cited by 11 publications

References 34 publications

Comparing healthcare systems between the Netherlands and Australia in management for children with acute gastroenteritis

Comparing healthcare systems between the Netherlands and Australia in management for children with acute gastroenteritis

Effect of Acupressure on Nausea and Vomiting among Children with Leukemia

National Consensus for the Management of Acute Gastroenteritis in Jordanian Children: Consensus Recommendations Endorsed by the Jordanian Paediatric Society

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