Oral oestrogen replacement therapy versus placebo for hot flushes

Comparative evaluation of raloxifene versus estrogen: Progestin on symptomatology, endometrium, and lipid profile in postmenopausal women

“…Similar to our observation, Campbell and Whitehead[ 7 ] demonstrated that estrogen was significantly more effective than placebo in reduction of vasomotor symptoms including hot flushes and also in the Cochrane reviews of published, randomized controlled trials of HRT, HRT reduced vasomotor symptoms compared with placebo [relative risk (RR), 0.10; 95% CI, 0.6-0.19]. [ 8 ] The improvements in the scores for sexual domain were similar to the study by Voss et al . [ 6 ] On in-group analysis, it was seen that raloxifene improved the scores in the depressed mood and somatic and sleep domains.…”

Comparative evaluation of raloxifene versus estrogen: Progestin on symptomatology, endometrium, and lipid profile in postmenopausal women

“…Similar to our observation, Campbell and Whitehead[ 7 ] demonstrated that estrogen was significantly more effective than placebo in reduction of vasomotor symptoms including hot flushes and also in the Cochrane reviews of published, randomized controlled trials of HRT, HRT reduced vasomotor symptoms compared with placebo [relative risk (RR), 0.10; 95% CI, 0.6-0.19]. [ 8 ] The improvements in the scores for sexual domain were similar to the study by Voss et al . [ 6 ] On in-group analysis, it was seen that raloxifene improved the scores in the depressed mood and somatic and sleep domains.…”

Yoga of Awareness program for menopausal symptoms in breast cancer survivors: results from a randomized trial

“…Another important limitation comes from the lack of an attention placebo control condition. The 31% reduction in hot flash total scores observed in this study fits within the range of changes often reported when placebos are administered in medication trials [22]. However, placebo effects may be smaller for behavioral interventions such as yoga than those seen in drug studies [9].…”

A Pilot Study to Examine a Combination Botanical for the Treatment of Menopausal Symptoms

“…Placebo-controlled studies of therapies for menopausal symptoms typically show hot flash severity and frequency decreasing by about 25% in treatment groups compared to control groups. 61,62 The 41.9% decrease in menopausal symptoms found in our study is encouraging, and further exploration of combination botanicals for menopausal women is warranted.…”

Comparative evaluation of raloxifene versus estrogen: Progestin on symptomatology, endometrium, and lipid profile in postmenopausal women

“…Similar to our observation, Campbell and Whitehead[ 7 ] demonstrated that estrogen was significantly more effective than placebo in reduction of vasomotor symptoms including hot flushes and also in the Cochrane reviews of published, randomized controlled trials of HRT, HRT reduced vasomotor symptoms compared with placebo [relative risk (RR), 0.10; 95% CI, 0.6-0.19]. [ 8 ] The improvements in the scores for sexual domain were similar to the study by Voss et al . [ 6 ] On in-group analysis, it was seen that raloxifene improved the scores in the depressed mood and somatic and sleep domains.…”

Yoga of Awareness program for menopausal symptoms in breast cancer survivors: results from a randomized trial

“…Another important limitation comes from the lack of an attention placebo control condition. The 31% reduction in hot flash total scores observed in this study fits within the range of changes often reported when placebos are administered in medication trials [22]. However, placebo effects may be smaller for behavioral interventions such as yoga than those seen in drug studies [9].…”

A Pilot Study to Examine a Combination Botanical for the Treatment of Menopausal Symptoms

“…Placebo-controlled studies of therapies for menopausal symptoms typically show hot flash severity and frequency decreasing by about 25% in treatment groups compared to control groups. 61,62 The 41.9% decrease in menopausal symptoms found in our study is encouraging, and further exploration of combination botanicals for menopausal women is warranted.…”

Comparative evaluation of raloxifene versus estrogen: Progestin on symptomatology, endometrium, and lipid profile in postmenopausal women

“…Similar to our observation, Campbell and Whitehead[ 7 ] demonstrated that estrogen was significantly more effective than placebo in reduction of vasomotor symptoms including hot flushes and also in the Cochrane reviews of published, randomized controlled trials of HRT, HRT reduced vasomotor symptoms compared with placebo [relative risk (RR), 0.10; 95% CI, 0.6-0.19]. [ 8 ] The improvements in the scores for sexual domain were similar to the study by Voss et al . [ 6 ] On in-group analysis, it was seen that raloxifene improved the scores in the depressed mood and somatic and sleep domains.…”

Yoga of Awareness program for menopausal symptoms in breast cancer survivors: results from a randomized trial

“…Another important limitation comes from the lack of an attention placebo control condition. The 31% reduction in hot flash total scores observed in this study fits within the range of changes often reported when placebos are administered in medication trials [22]. However, placebo effects may be smaller for behavioral interventions such as yoga than those seen in drug studies [9].…”

A Pilot Study to Examine a Combination Botanical for the Treatment of Menopausal Symptoms

“…Placebo-controlled studies of therapies for menopausal symptoms typically show hot flash severity and frequency decreasing by about 25% in treatment groups compared to control groups. 61,62 The 41.9% decrease in menopausal symptoms found in our study is encouraging, and further exploration of combination botanicals for menopausal women is warranted.…”