Oral mucositis in children suffering from acute lymphoblastic leukaemia

Pels, Elżbieta

doi:10.5114/wo.2012.27331

Cited by 16 publications

(25 citation statements)

References 32 publications

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“…It is extremely important to undergo the dental treatment in ALL individuals and to be screened to oral infections [17,18]. Curiously,ALL individuals could present good dental condition compared with other populations as mentioned in our study [19]. In our study both groups had similar access to dental care without any considerable sociodemographic differences [20].…”

Section: Discussionmentioning

confidence: 58%

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Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B

Monteiro

Ribeiro

Batista

et al. 2019

RGO, Rev. Gaúch. Odontol.

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Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin BCandida na cavidade oral de indivíduos pediátricos com LLA e sua susceptibilidade à nistatina e à anfotericina B ABSTRACT Objective: The aim of this study was to evaluate the prevalence of Candida colonizationon oral cavity of pediatric individuals with acute lymphocytic leukemia (ALL) and its susceptibility/resistance to nystatin and amphotericin B. Methods: This was a cross sectional study with observational, descriptive and analytic approach. Saliva was collected from40 individuals diagnosed with ALL and from40 healthy subjects, as a comparative group, matched by age and gender with ALL group. The mean age for both groups were 8 years-old. The isolation and identification of the Candidaspecies were performed using the CHROMagarCandidaTM and confirmed by polymerase chain reaction. The samples were subjected to antifungal susceptibility by microdilution assay for nystatin and amphotericin B. Salivary alterations and chemotherapy-induced oralmucositis were evaluated using modifiedOral Assessment Guide. Results: The positivity to Candida was higher inALL individuals (32.5%,13/40)than in a comparative group(2.5%, 1/40) (p<0.001). Candida albicans was the most prevalent strain (86.6%). The mucositis was directly associated with positive Candidacolonization (p=0.017) in the ALL group but not related with salivary alterations (p= 0.479). Six strains of C. albicans (54.5%), on ALL group, were resistant to nystatin oral mucositis in these individuals. C. albicans was the prevalent strain and most samples were resistant to antifungal agents tested, nystatin and amphotericin B. RESUMOObjetivo: o objetivo deste estudo foi avaliar a prevalência e colonização de Candida na cavidade oral de indivíduos pediátricos com leucemia linfocítica aguda (LLA) e sua susceptibilidade/resistência à nistatina e à anfotericina B. Métodos: estudo transversal observacional com abordagem descritiva e analítica. A saliva foi coletada de 40 indivíduos diagnosticados com LLA e de 40 indivíduos saudáveis, como grupo comparativo, combinados por idade e sexo com o grupo LLA. A idade média para ambos os grupos foi de 8 anos de idade. O isolamento e a identificação das espécies de Candida foram realizados utilizando o CHROMagarCandidaTM e confirmados pela reação em cadeia da polimerase. As amostras foram submetidas a susceptibilidade antifúngica por meio de ensaio de microdiluição para nistatina e anfotericina B. As alterações salivares e a mucosite oral induzida por quimioterapia foram avaliadas utilizando o Guia de avaliação modificada. Resultados: A positividade para Candida foi superior aos indivíduos in situ (32,5%, 13/40) do que em um grupo comparativo (2,5%, 1/40) (p <0,001). Candida albicans foi a cepa mais prevalente (86,6%). A mucosite foi diretamente associada à colonização positive por Candida (p = 0,017) no grupo LLA, mas não relacionada com alterações salivares (p = 0,479). Seis estirpes de C. albicans (54,5%), no grupo LLA, era...

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Section: Discussionmentioning

confidence: 58%

“…Probably, induction phase reduces inflammatory response, even on salivary level, favoring Candida colonization. As previously showed, the induction phase had more association of oral complications [19] but them could remain on maintenance phase. The association between the absence of candidosis and mucositis was evident.…”

Section: Discussionmentioning

confidence: 74%

Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B

Monteiro

Ribeiro

Batista

et al. 2019

RGO, Rev. Gaúch. Odontol.

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“…For these authors the most frequent oral lesions were mucositis [16,12], candidiasis [17,6], periodontitis [18] and gingivitis [17]. The most frequent sites of involvement of oral manifestations were oral mucosa and labial mucosa [19].…”

Section: Discussionmentioning

confidence: 99%

Oral Manifestations and Salivary pH Changes in Children undergoing Antineoplastic Therapy

Hanna¹,

Botti²,

Araújo

et al. 2016

Pesqui. bras. odontopediatria clín. integr.

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Objective: To identify the oral manifestations and salivary pH before and after chemotherapy in pediatric patients. Material and Methods: The sample consisted of 46 children. It was included children from 2 to 12 years, diagnosed with Acute Lymphoblastic Leukemia (ALL) and they would be subjected to chemotherapy. The first evaluation was performed before chemotherapy and consisted of anamnesis, oral clinical examination and saliva collection to measure the pH. The second evaluation was performed among 10 to 15 days after the start of chemotherapy treatment and consisted of new saliva collection and clinical examination. Results: The results showed that the gender most affected by childhood cancer was male. The predominant age group were children aged 8-12 years. The most frequent oral manifestations were mucositis (35%), xerostomia (26%), toothache and dysphagia (22%). There was also a significant reduction in salivary pH after chemotherapy, p <0.0001, indicating that the average pre and post chemotherapy are different (Δ = 10.6) with statistical significance at the 5% level. Conclusion: Patients with ALL can present any lesion in the oral cavity during or after the start of chemotherapy and undergo changes in the amount of salivary pH. The dentist needs and know the oral manifestations and intervene in the oral health of patients with ALL, contributing and assisting in their treatment.

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“…15 The Score 4= Ulcers and pseudomembranous that prevent eating. 18 Information on diseases such as step therapy, blood tests and patients' age were extracted from patients' medical records. Finally, the personal hygiene practices were taught to the participants.…”

Section: E T H O D Smentioning

confidence: 99%

Oral Health Status of South-Eastern Iranian Children with Acute Lymphoblastic Leukemia

Afshar¹,

Farahmandinia²,

torabi³

et al. 2020

jemds

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A B S T R A C T BACKGROUNDAcute leukemia is characterized by the progressive excessive production of leukocytes in the bone marrow as well as the arrival of immature cells into the peripheral blood. The present study aimed to evaluate the oral hygiene status in patients with acute leukemia. METHODSThe present study included 50 ALL patients referred to the affiliated oncology centers of Kerman University of Medical Sciences from April to December 2015 and 52 healthy children. Data collected from the oral examination included the DMFT/dmft and plaque indexes and the presence of mucositis. Information about the diseases, blood test results, the patients' age, and the type of drug was obtained from medical records. Data was analysed through SPSS software, T-test and Mann-Whitney test at a significance level of 0.05. RESULTSGrade 1 and 2 mucositis was observed in 6 (0.12%) and 1 (0.2%) patients respectively. The plaque index was significantly higher in patients than the healthy group (p= 0.033). The average missing teeth was higher in the ALL group, but it was not statistically significant. There were no statistically significant differences between the individuals with mucositis and those without mucositis (p=0.503). There were no statistically significant differences between the patients and healthy group in terms of the mean DMFT/dmft index. CONCLUSIONSThere were no statistically significant differences between the patients and healthy group in DMFT/dmft index. Statistically significant differences were seen between patients and healthy groups in terms of OHI-S index.

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Oral mucositis in children suffering from acute lymphoblastic leukaemia

Cited by 16 publications

References 32 publications

Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B

Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B

Oral Manifestations and Salivary pH Changes in Children undergoing Antineoplastic Therapy

Oral Health Status of South-Eastern Iranian Children with Acute Lymphoblastic Leukemia

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