Oral mucosal soft tissue necrosis caused by superinfection

Helovuo, Hilkka; Forssell, K; Hakkarainen, Kati

doi:10.1016/0030-4220(91)90358-j

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…An increasing prevalence of β‐lactamase activity among oral bacterial isolates has been reported , which is largely thought to be the result of plasmid and transposon‐mediated conjugal transfer and dissemination of β‐lactamase‐encoding genes among microorganisms surviving following selective pressure from β‐lactam antibiotics . Beta‐lactamases may predispose systemic penicillin monotherapy, unprotected by β‐lactamase inhibitors, to oral cavity treatment failures, such as recalcitrant orofacial infections and periodontal surgical flap necrosis , as well as enhance periodontal abscess risk in untreated periodontitis subjects .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of β‐lactamase‐producing bacteria in human periodontitis

Rams

Degener

Winkelhoff

2012

J of Periodontal Research

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The occurrence of β-lactamase-positive subgingival bacterial species in more than half of the subjects with severe chronic periodontitis raises questions about the therapeutic potential of single-drug regimens with β-lactam antibiotics in periodontal therapy. The in vitro effectiveness of metronidazole against nearly all recovered β-lactamase-producing subgingival bacterial species further supports clinical periodontitis treatment strategies involving the combination of systemic amoxicillin plus metronidazole.

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Section: Discussionmentioning

confidence: 99%

Prevalence of β‐lactamase‐producing bacteria in human periodontitis

Rams

Degener

Winkelhoff

2012

J of Periodontal Research

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“…Micro-organisms uncommon to the oral cavity have also been identified from necrotic oral mucosal soft tissue after oral flap surgery procedures combined with antimicrobial agents (Helovuo et al 1991). Micro-organisms uncommon to the oral cavity have also been identified from necrotic oral mucosal soft tissue after oral flap surgery procedures combined with antimicrobial agents (Helovuo et al 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Overgrowth of yeast, enteric bacterial species and staphylococci in refractory periodontal patients after doxycycline therapy has been reported earlier, but its importance for the outcome of periodontal treatment has not been thoroughly studied (Rams et al 1990). Micro-organisms uncommon to the oral cavity have also been identified from necrotic oral mucosal soft tissue after oral flap surgery procedures combined with antimicrobial agents (Helovuo et al 1991). In the present study a small number of yeasts, enteric bacteria or staphylococci were isolated from the periodontal pockets of 11 out of 17 refractory periodontitis patients.…”

Section: Discussionmentioning

confidence: 99%

Tetracycline‐resistant micro‐organisms recovered from patients with refractory periodontal disease

Olsvik

Hansen

Tenover

et al. 1995

J Clinic Periodontology

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Tetracycline in combination with scaling and root planing is frequently used to treat refractory periodontal disease. This study examined tetracycline resistance in bacteria recovered from periodontal pockets of patients with refractory periodontitis. Bacterial isolates resistant to 10 micrograms/ml of tetracycline were isolated from plaque samples of 17 patients, of whom 6 had received tetracycline within 8 weeks prior to sampling. Minimal inhibitory concentrations (MICs) of tetracycline and minocycline were determined by agar dilution. In the 6 patients who had received tetracycline, a mean of 22.9% (+/- 38.2) of the total cultivable subgingival flora were resistant to tetracycline, compared with a mean of 7.2% (+/- 8.5) in the untreated group. Although various organisms were isolated, in most patients, the tetracycline-resistant organisms were dominated by Streptococcus spp. Overgrowth of Candida was found in one patient, and of Enterobacteriaceae in another patient, while small numbers of yeast or Staphylococcus spp. were isolated from the plaque samples of 9 others. 3 out of 4 patients who did not respond to tetracycline treatment had a variety of tetracycline-resistant anaerobic Gram-negative rods present. No correlation was found between increased proportions of tetracycline resistance in the whole bacterial sample and the presence of resistant periodontal pathogens.

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“…Finally, Helovuo et al described oral infections due to "multiply resistant bacteria" including Enterobacter spp. and other gram-negative bacilli (95). Previous courses of antimicrobial agents for periodontal infections may have selected for these resistant strains (95).…”

Section: Infections Of Skin and Soft Tissuesmentioning

confidence: 99%

Enterobacter spp.: pathogens poised to flourish at the turn of the century

1997

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Knowledge of the genus Enterobacter and its role in human disease has expanded exponentially in recent years. The incidence of infection in the hospital and the community has increased. New clinical syndromes have been recognized. Enterobacter spp. have also been implicated as causes of other syndromes that traditionally have been associated almost exclusively with more easily treatable pathogens, such as group A streptococci and staphylococci. Rapid emergence of multiple-drug resistance has been documented in individual patients during therapy and in populations and environments with strong selective pressure from antimicrobial agents, especially the cephalosporins. Therapeutic options for patients infected with multiply resistant strains have become severely limited. Carbapenems or, alternatively, fluoroquinolones are the most predictively active options, although resistance to both classes has been observed on rare occasions. Enterobacter spp. appear well adapted for survival and even proliferation as the turn of the century approaches.

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Oral mucosal soft tissue necrosis caused by superinfection

Cited by 7 publications

References 3 publications

Prevalence of β‐lactamase‐producing bacteria in human periodontitis

Prevalence of β‐lactamase‐producing bacteria in human periodontitis

Tetracycline‐resistant micro‐organisms recovered from patients with refractory periodontal disease

Enterobacter spp.: pathogens poised to flourish at the turn of the century

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