Tetracycline‐resistant micro‐organisms recovered from patients with refractory periodontal disease

Olsvik, Bente; Hansen, B. Frode; Tenover, Fred C.; Olsen, Ingar

doi:10.1111/j.1600-051x.1995.tb00166.x

Cited by 42 publications

(39 citation statements)

References 31 publications

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“…The tet (M) determinant is commonly found in some subgingival species considered "beneficial" such as oral streptococci, Veillonella and Actinomyces spp. 74,104,105,121 . Lacroix and Walker 74 (1995) subcultured and identified 204 tetracycline-resistant strains from 68 patients with chronic periodontitis.…”

Section: Mechanism Of Action and Resistancementioning

confidence: 99%

Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs

et al. 2012

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Antibiotics are important adjuncts in the treatment of infectious diseases, including periodontitis. The most severe criticisms to the indiscriminate use of these drugs are their side effects and, especially, the development of bacterial resistance. The knowledge of the biological mechanisms involved with the antibiotic usage would help the medical and dental communities to overcome these two problems. Therefore, the aim of this manuscript was to review the mechanisms of action of the antibiotics most commonly used in the periodontal treatment (i.e. penicillin, tetracycline, macrolide and metronidazole) and the main mechanisms of bacterial resistance to these drugs. Antimicrobial resistance can be classified into three groups: intrinsic, mutational and acquired. Penicillin, tetracycline and erythromycin are broad-spectrum drugs, effective against gram-positive and gram-negative microorganisms. Bacterial resistance to penicillin may occur due to diminished permeability of the bacterial cell to the antibiotic; alteration of the penicillin-binding proteins, or production of β-lactamases. However, a very small proportion of the subgingival microbiota is resistant to penicillins. Bacteria become resistant to tetracyclines or macrolides by limiting their access to the cell, by altering the ribosome in order to prevent effective binding of the drug, or by producing tetracycline/macrolide-inactivating enzymes. Periodontal pathogens may become resistant to these drugs. Finally, metronidazole can be considered a prodrug in the sense that it requires metabolic activation by strict anaerobe microorganisms. Acquired resistance to this drug has rarely been reported. Due to these low rates of resistance and to its high activity against the gram-negative anaerobic bacterial species, metronidazole is a promising drug for treating periodontal infections.

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Section: Mechanism Of Action and Resistancementioning

confidence: 99%

Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs

et al. 2012

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“…Several studies have shown that tetracyclines are active against A. actinomycetemcomitans (15,17,23). Tetracyclines are extensively used as adjuncts in the treatment of periodontitis, a disease affecting the tooth-supporting tissues (gingiva, periodontal ligament, and alveolar bone) and resulting in tooth loss (21,23).…”

mentioning

confidence: 99%

Iron-Chelating Activity of Tetracyclines and Its Impact on the Susceptibility of Actinobacillus actinomycetemcomitans to These Antibiotics

Grenier¹,

Huot²,

Mayrand

2000

Antimicrob Agents Chemother

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Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possess iron-chelating activity in a colorimetric siderophore assay. Determination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus actinomycetemcomitans was only slightly influenced by the presence of an excess of iron that likely saturates the antibiotic. On the other hand, the MICs of doxycycline and minocycline were significantly lower for A. actinomycetemcomitans cultivated under iron-poor conditions than under ironrich conditions.

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“…; Olsvik, 1995). Strains GF10, MK1, UM3 and W1219 T were isolated from periodontal pockets and W2274 was isolated from a dentoalveolar abscess.…”

mentioning

confidence: 99%

Bulleidia extructa gen. nov., sp. nov., isolated from the oral cavity.

Downes¹,

Olsvik²,

Hiom³

et al. 2000

International Journal of Systematic and Evolutionary Microbiology

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Five strains of anaerobic non-sporing Gram-positive bacilli isolated from advanced periodontitis (four strains) and a dentoalveolar abscess (one strain) that did not correspond to existing species were subjected to phenotypic and genetic characterization. Following 16S rDNA sequence analysis, they were found to constitute a novel branch of the low GMC Gram-positive division of the phylogenetic tree related to Erysipelothrix rhusiopathiae and Holdemania filiformis. A new genus Bulleidia, and the species Bulleidia extructa, are proposed. Growth of B. extructa in broth media was poor but was enhanced by the addition of fructose, glucose or maltose together with Tween 80. Glucose and maltose were fermented and arginine was hydrolysed. Acetate, lactate and trace amounts of succinate were the end products of glucose fermentation. The GMC content of the DNA of the type strain is 38 mol %. The type strain of Bulleidia extructa is DSM 13220 T .

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Tetracycline‐resistant micro‐organisms recovered from patients with refractory periodontal disease

Cited by 42 publications

References 31 publications

Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs

Mechanisms of action of systemic antibiotics used in periodontal treatment and mechanisms of bacterial resistance to these drugs

Iron-Chelating Activity of Tetracyclines and Its Impact on the Susceptibility of Actinobacillus actinomycetemcomitans to These Antibiotics

Bulleidia extructa gen. nov., sp. nov., isolated from the oral cavity.

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