Oral microbiota in human systematic diseases

Abstract

Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through two-way communication along the oral cavity and the systemic organs. The oral cavity is one of the most important interaction windows between the human body and the environment. The microenvironment at different sites in the oral cavity has different microbial compositions and is regulated by complex signaling, hosts, and external environmental factors. These processes may affect or reflect human health because certain health states seem to be related to the composition of oral bacteria, and the destruction of the microbial community is related to systemic diseases. In this review, we discussed emerging and exciting evidence of complex and important connections between the oral microbes and multiple human systemic diseases, and the possible contribution of the oral microorganisms to systemic diseases. This review aims to enhance the interest to oral microbes on the whole human body, and also improve clinician’s understanding of the role of oral microbes in systemic diseases. Microbial research in dentistry potentially enhances our knowledge of the pathogenic mechanisms of oral diseases, and at the same time, continuous advances in this frontier field may lead to a tangible impact on human health.

Mucosal immune cell populations and the bacteriome of adenoids and tonsils from people living with HIV on suppressive antiretroviral therapy

“…The oral microbiota has been extensively studied ( Li et al, 2022 ). This is due to the new insights into the role of the latter in periodontal diseases and systemic diseases including cardiovascular diseases ( Peng et al, 2022 ). Results in HIV infection have been inconsistent and contradictory ( Li et al, 2021 ).…”

Salivary microbiota of periodontitis aggravates bone loss in ovariectomized rats

“…The oral cavity, which is the entry site into the gastrointestinal tract, harbors diverse microbial communities (Peng et al, 2022), and previous reports support the hypothesis that oral and gastrointestinal mucosae are microbiologically connected (Read et al, 2021;Bao et al, 2022). In addition, the salivary microbiota of periodontitis, which is rich in oral pathobionts, can translocate from the oral cavity to the intestine and disrupt the colonization resistance of gut-resident microbiota (Kitamoto et al, 2020).…”

Natural products from traditional medicine as promising agents targeting at different stages of oral biofilm development

“…In recent years, large evidence proved the interaction between oral infectious diseases and oral microbiome, such as caries (Bowen et al, 2018), periodontitis (Lamont et al, 2018), and oral cancer (Irfan et al, 2020). Many systematic diseases, such as those from the gastrointestinal system and nervous system are also associated with oral microbial dysbiosis (Peng et al, 2022). The relationships between oral microbiome and oral or systematic health highlight the importance to maintain the balance of oral microbiome.…”