Oral microbial carriage in oral squamous cell carcinoma patients at the time of diagnosis and during radiotherapy – A comparative study

Sonalika, Wanjari Ghate; Tayaar, S Amsavardani; Bhat, Kishore; Patil, B. R.; Muddapur, M.V.

doi:10.1016/j.oraloncology.2012.03.018

Cited by 35 publications

(48 citation statements)

References 39 publications

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“…The oral microbiota of patients with head and neck cancer presented several peculiarities, such as a higher frequency of colonization of yeasts of the genus Candida 22,23 , which have been implicated in the production of nitrosamines capable to activate proto-oncogenes responsible for the development of the head and neck cancer 24 , besides Gram-positive anaerobes of the genus Actinomyces, Gram-negative anaerobes of genera Fusobacterium, Prevotella, and Porphyromonas, microaerophillics such as Capnocytophaga, and Gramnegative enteric rods of the family Enterobacteriaceae 25 . The high prevalence of the species of Enterobacteriaceae on the surface of malignant neoplasms in the mouth may have impact on oral and/or systemic infectious diseases and could reflect the microbial adhesion abilities of bacteria and receptors of the neoplastic cells 23 .…”

Section: Oral Microbiota Of the Patient With Head And Neck Cancermentioning

confidence: 99%

“…The high prevalence of the species of Enterobacteriaceae on the surface of malignant neoplasms in the mouth may have impact on oral and/or systemic infectious diseases and could reflect the microbial adhesion abilities of bacteria and receptors of the neoplastic cells 23 . In addition, the presence of enteric Gram-negative rods on the surface of oral soft tissues could exacerbate microbial proteolytic activity on fibronectin and expose receptors for adhesion of other members of the family Enterobacteriaceae.…”

Section: Oral Microbiota Of the Patient With Head And Neck Cancermentioning

confidence: 99%

“…Mucositis is associated with ulcerated areas, hinder nutrition and might facilitate the deployment of local or systemic infections 5 , usually caused by opportunistic microorganisms, such as enteric pathogens, anaerobic Gramnegative rods and yeasts 7,19,20,41,42 sometimes already present in higher proportions in cancer patients before RT 23 . The presence, severity and persistence of xerostomia seem to be the main factors associated with the presence of candidiasis in irradiated patients, facilitating the colonization of surfaces that previously did not harbor these fungi, allowing the growth of yeast populations 43,44 .…”

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

“…This phenomenon is also exacerbated by the acidification of the oral biofilm and the reduction of the buffer capacity of the residual saliva. The prevalence and populations of yeasts are directly related to RT 23,34,44 , being involved in the severity of mucositis and secondary infections.…”

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

“…varies from 20 to 70% in patients undergoing RT, and some studies suggest that other species besides C. albicans are more favored in the irradiated patients 7,45 . However, literature has failed to discover any advantage for non-albicans Candida during or after RT 23,34,44,46,47 . The prevention/control of oral candidiasis, by improving oral hygiene standards, use of antifungal solutions and nutritional support, could also be a measure with impact on mucositis intensity in irradiated patients 7,34 , particularly the systemic use of fluconazole and aqueous solution of nystatin 20,21,34,47 .…”

Section: Radio-induced Mucositis and Candidiasismentioning

confidence: 99%

See 4 more Smart Citations

Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review

Jardim¹,

Cunha-Correia²,

Okamoto³

et al. 2017

Arch Health Invest

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Oral microbiota and mucositis in patients with head and neck cancer undergoing radiotherapy: literature review AbstractThe occurrence and severity of mucositis are the main complaints of patients with head and neck cancer submitted to radiotherapy (RT). This condition appears to be associated with changes in the oral microbiota and other side effects of RT, such as xerostomia and candidiasis. The aim of this study was to evaluate the effect of RT on the oral microbiota and its impact on radioinduced mucositis through literature review. Descriptors were selected for the collection of information in different databases, especially SciELO, BIREME, LILACS and PubMed. It was decided to consider only articles published since 1985. The descriptors radiotherapy, mucositis, dental caries, xerostomia, head and neck neoplasms and health promotion were used. It was selected 91 articles specifically discussing the microbiological aspects of mucositis, dental caries, oral candidiasis and microbial effects on the oral health of cancer patients, and 59 were included in the review. It was observed that microbial contamination is a secondary phenomenon capable of exacerbate the inflammation induced by the interaction of the radiation with the oral tissues, aggravating mucositis mainly in patients who present precarious conditions of oral hygiene, which reinforces the role of preventive dentistry in the follow up of the irradiated patient. Descriptors: Radiotherapy; Mucositis; Dental Caries; Xerostomia; Head And Neck Neoplasms; Health Promotion. ResumoA ocorrência e a severidade da mucosite constituem as principais queixas dos pacientes com câncer de cabeça e pescoço submetidos à radioterapia (RT). Essa condição parece estar associada às modificações da microbiota bucal e aos demais efeitos colaterais da RT, como xerostomia e a candidíase. O presente trabalho de revisão da literatura teve como objetivo avaliar o efeito que a RT exerce sobre a microbiota bucal e seu impacto na mucosite radioinduzida através de revisão de literatura. Foram selecionados os descritores para a coleta de informações em diferentes bancos de dados, destacando-se SciELO, BIREME, LILACS e PubMed. Decidiu-se considerar apenas artigos publicados desde 1985. Utilizou-se como descritores os termos radioterapia, mucosite, cárie dentária, xerostomia, neoplasias de cabeça e pescoço e promoção da saúde. Foram selecionados 91 artigos que discutiam especificamente os aspectos microbiológicos da mucosite, cárie dentária, candidíase oral e efeitos microbianos na saúde bucal de pacientes oncológicos e 59 foram incluídos na revisão. Observou-se que a contaminação microbiana é fenômeno secundário capaz de agravar a inflamação induzida pela interação da radiação com os tecidos bucais, agravando-se, principalmente, em pacientes que apresentam condições precárias de higiene bucal, o que reforça o papel da odontologia preventiva no acompanhamento do paciente irradiado. Descritores: Radioterapia; Mucosite; Cárie Dentária; Xerostomia; Neoplasias de Cabeça e Pescoço; Promoção da...

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