Oral Microbiome: Potential Link to Systemic Diseases and Oral Cancer

Vasquez, Adrian A.; Ram, Jeffrey L.; Qazazi, Milad S.; Sun, Jun; Kato, Ikuko

doi:10.1007/978-1-4939-7534-1_9

Cited by 5 publications

(10 citation statements)

References 283 publications

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“…Action of such bacteria in the tumour microenvironment are primarily driven by heightening of the innate immunity against them 47 . Streptococcus and Prevotella have also been postulated to have similar effect on the change in cytokine profile and to activate of innate immunity 36 . Porphyromonas gingivalis is also reported to increase the invasiveness of the oral cancer cells, via induction and activation of pro‐MMP9 48 .…”

Section: Microbes Associated With Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Influence of pathogens on host genome and epigenome in development of head and neck cancer

Desai

2023

Cancer Reports

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BackgroundHead and neck cancer (HNSCC) is a heterogeneous group of cancers, affecting multiple regions such as oral cavity, pharynx, larynx, and nasal region, each showing a distinct molecular profile. HNSCC accounts for more than 6 million cases worldwide, soaring mainly in the developing countries.Recent findingsThe aetiology of HNSCC is complex and multifactorial, involving both genetic and environmental factors. The critical role of microbiome, which includes bacteria, viruses, and fungi, is under spotlight due to the recent reports on their contribution in the development and progression of HNSCC. This review focuses on the effect of opportunistic pathogens on the host genome and epigenome, which contributes to the disease progression. Drawing parallels from the host‐pathogen interactions observed in other tumour types arising from the epithelial tissue such as colorectal cancer, the review also calls attention to the potential explorations of the role of pathogens in HNSCC biology and discusses the clinical implications of microbiome research in detection and treatment of HNSCC.ConclusionOur understanding of the genomic effects of the microbes on the disease progression and the mechanistic insights of the host‐pathogen interaction will pave way to novel treatment and preventive approaches in HNSCC.

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Section: Microbes Associated With Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Influence of pathogens on host genome and epigenome in development of head and neck cancer

Desai

2023

Cancer Reports

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“…The human oral cavity harbours one of the most diverse microbiomes in the human body; it consists of more than 2000 bacterial taxa and includes viruses, fungi, protozoa, archaea and bacteria, as well as a large number of opportunistic pathogens that are involved in dental, periodontal and systemic diseases [ 14 , 15 , 16 ]. The oral virome often includes viruses known to be oncogenic to humans, i.e., HPV, EBV, KSHV and HIV-1 [ 6 ].…”

Section: Head and Neck Cancermentioning

confidence: 99%

“…The most extensively studied is Porphyromonas gingivalis (Pg) is a member of the red complex, which consist of the three most pathogenic bacteria in periodontitis [ 21 , 22 ]. Pg is a non-motile Gram-negative obligate anaerobic intracellular bacterium which expresses an array of virulence factors [ 16 , 23 , 24 ]. A recent meta-analysis by Xiao et al presented the summary odd ratio (OR) of 2.16 (95% confidence interval (CI) 1.34–3.47) for the risk of developing various cancers combined, including oral, oesophageal and gastric cancer [ 25 ].…”

Section: Head and Neck Cancermentioning

confidence: 99%

Bacterial-Viral Interactions in Human Orodigestive and Female Genital Tract Cancers: A Summary of Epidemiologic and Laboratory Evidence

Kato

Zhang

Sun

2022

Cancers

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Infectious agents, including viruses, bacteria, fungi, and parasites, have been linked to pathogenesis of human cancers, whereas viruses and bacteria account for more than 99% of infection associated cancers. The human microbiome consists of not only bacteria, but also viruses and fungi. The microbiome co-residing in specific anatomic niches may modulate oncologic potentials of infectious agents in carcinogenesis. In this review, we focused on interactions between viruses and bacteria for cancers arising from the orodigestive tract and the female genital tract. We examined the interactions of these two different biological entities in the context of human carcinogenesis in the following three fashions: (1) direct interactions, (2) indirect interactions, and (3) no interaction between the two groups, but both acting on the same host carcinogenic pathways, yielding synergistic or additive effects in human cancers, e.g., head and neck cancer, liver cancer, colon cancer, gastric cancer, and cervical cancer. We discuss the progress in the current literature and summarize the mechanisms of host-viral-bacterial interactions in various human cancers. Our goal was to evaluate existing evidence and identify gaps in the knowledge for future directions in infection and cancer.

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“…The Human microbiome has been annotated to determine the association between microbiota perturbation and health/disease [ 2 , 4 ]. Microorganisms residing in the human oral cavity are termed oral microbiome; they are one of the essential components of the human microbiome [ 5 ]. These microorganisms are crucial to host health by resisting pathogens, maintaining delicate homeostasis and their profound modulating influence on immune cell function [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening

Oyeyemi,

Kaur,

Paramraj

et al. 2023

Heliyon

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Oral Microbiome: Potential Link to Systemic Diseases and Oral Cancer

Cited by 5 publications

References 283 publications

Influence of pathogens on host genome and epigenome in development of head and neck cancer

Influence of pathogens on host genome and epigenome in development of head and neck cancer

Bacterial-Viral Interactions in Human Orodigestive and Female Genital Tract Cancers: A Summary of Epidemiologic and Laboratory Evidence

Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening

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