2015
DOI: 10.1016/j.ijid.2015.04.007
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Oral Manifestations of Secondary Syphilis

Abstract: Known as "the great imitator," secondary syphilis may clinically manifest itself in myriad ways, involving different organs including the oral mucosa, and mimicking, both clinically and histologically, several diseases, thereby making diagnosis a challenge for clinicians. We highlight the clinical aspects of oral manifestation in 7 patients with secondary syphilis. Clinicians should consider secondary syphilis in the differential diagnosis of ulcerative and/or white oral lesions.

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Cited by 56 publications
(56 citation statements)
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“…Although oral lesions and skin manifestations may occur at any stage of the disease, they are mainly associated with secondary syphilis 13,14 , which occurs in approximately 30% of untreated patients. In this phase, several systemic and mucocutaneous manifestations of the disease, such as fever, malaise, weight loss, pharyngitis, and lymphadenopathy 5,6,14,15 occur.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although oral lesions and skin manifestations may occur at any stage of the disease, they are mainly associated with secondary syphilis 13,14 , which occurs in approximately 30% of untreated patients. In this phase, several systemic and mucocutaneous manifestations of the disease, such as fever, malaise, weight loss, pharyngitis, and lymphadenopathy 5,6,14,15 occur.…”
Section: Discussionmentioning
confidence: 99%
“…Different from primary syphilis, that is presented as a single painless chancre, the oral lesions of secondary syphilis are usually symptomatic and multiple 11 . The most common oral lesions associated with secondary syphilis are ulcers or erosions and "mucous patches" with two subtypes: slightly elevated-type plaques with ulcerated surface occasionally; or multiple mucous patches that may coalesce to give rise to serpiginous lesions, described as snail track ulcers [4][5][6][12][13][14] . As seen in our patient, the usually affected sites are soft palate, tongue, lips, buccal mucosa, and vestibular mucosa 5,14 .…”
Section: Discussionmentioning
confidence: 99%
“…Aunque las lesiones orales pueden manifestarse en todas las etapas se asocian principalmente con la sífilis secundaria. Se observan manifestaciones orales en el 30% de los casos de los pacientes, pero rara vez como únicas manifestaciones de la infección [16][17][18][19]. Se caracterizan por lesiones eritematosas, erosivas, papulosas o ulcerosas, incluso vegetantes.…”
Section: Palabrasunclassified
“…Un 25% de pacientes tienen episodios recurrentes de sífilis secundaria fundamentalmente en el primer año durante la fase latente precoz, que puede manifestarse exclusivamente en la mucosa oral como en el caso que presentamos [20]. La etapa secundaria de la enfermedad toma una variedad de manifestaciones orales, imitando otras lesiones más frecuentes en la cavidad oral, permaneciendo sin tratamiento adecuado [16][17][18][19][20][21][22]. El análisis de la historia clí-nica de un paciente sospechoso, combinado con el examen físico y los exámenes serológi-cos, normalmente proporcionan un diagnóstico concluyente de la enfermedad, y la biopsia no se requiere normalmente como un diagnóstico inicial [22].…”
Section: Palabrasunclassified
“…A doença adquirida pode ser classificada em quatro estágios: primário, secundário, latente e terciário. As lesões orais são, principalmente, associadas à sífilis secundária, embora todas as etapas possam apresentar manifestações bucais 2 . A sífilis também pode ocorrer como coinfecção em pacientes HIV positivos 1 .…”
Section: Introductionunclassified