Oral manifestations of gold allergy

Laeijendecker, Ronald; Joost, Th. van

doi:10.1016/s0190-9622(94)70018-4

Cited by 107 publications

(57 citation statements)

References 17 publications

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“…Apart from these drugs, gold was probably the most common agent recognized as initiating an LP-like eruption (Penneys et al, 1974). Gold salts can cause a range of mucocutaneous lesions (Hakala et al, 1986), of which oral lichenoid lesions may be the first (Brown et al, 1993;Laeijendecker and Van loost, 1994).…”

Section: (3) Drugsmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

467

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Section: (3) Drugsmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

467

461

View full text Add to dashboard Cite

show abstract

“…1,3,12 The concept of contact allergy to dental restorative materials aggravating or inducing OLP is well recognized but somewhat controversial. [13][14][15] However, several authors have reported resolution of signs and symptoms in OLP after replacement of amalgam, particularly if there was a positive patch test result to mercury, which is the most important allergen in amalgam. 6,[16][17][18] The aim of this study was to determine contact allergies in patients with OLP and amalgam fillings and to investigate whether there are specific subgroups of patients with OLP, based on differences in the relationship between oral lesions and amalgam fillings.…”

mentioning

confidence: 99%

Oral Lichen Planus and Allergy to Dental Amalgam Restorations

Laeijendecker

Dekker²,

Burger³

et al. 2004

Arch Dermatol

107

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To determine contact allergies in patients with oral lichen planus and to monitor the effect of partial or complete replacement of amalgam fillings following a positive patch test reaction to ammoniated mercury, metallic mercury, or amalgam. Design:In group A (20 patients), the oral lesions were confined to areas in close contact with amalgam fillings. In group B (20 patients), the lesions extended 1 cm beyond the area of contact with amalgam fillings. In group C (20 patients), the oral lesions had no topographic relationship with amalgam fillings. Partial or complete replacement of amalgam fillings was recommended if there was a positive patch test reaction to ammoniated mercury, metallic mercury, or amalgam. Control group D (20 patients) had signs of allergic contact dermatitis.Results: Amalgam fillings were replaced in 13 patients of group A, with significant improvement. Dental amalgam

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“…A more recent case report discussed a case of systemic dermatitis after placement of a cobalt-chromiummolybdenum implant in total knee arthroplasty (TKA); thanks to a revision TKA with a zirconium-niobium implant, pruritus resolved 3 days and eczema 2 months after surgery [16]. Apart from orthopedic implants, there are numerous case reports linking adverse immune reactions to metallic implants used in cardiovascular [17][18][19], plastic [20], and dental surgery [21][22][23]. There are more case reports concerning the use of stainless steel and cobalt alloy implants than titanium alloy implants [9].…”

Section: The Rising Potential Impact Of Metal Hypersensitivitymentioning

confidence: 99%

Hypersensitivity Reactions to Implanted Metal Devices: Facts and Fictions

2016

J Investig Allergol Clin Immunol

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The use of metals in the medical field has become increasingly prevalent over the past few decades. Patients find themselves being exposed to metals in a variety of ways, ranging from external exposure to instruments such as the stainless steel in surgical blades to internal exposure via medical devices being implanted in their bodies. There has been growing interest in the possibility of developing hypersensitivity reactions to constituent metals in medical implant devices, both in cutaneous and systemic forms. Hypersensitivity reactions to metals are uncommon, but they are reported and require appropriate evaluation and management, particularly if they are symptomatic. In view of the lack of consensus in the field on the appropriate steps to evaluate and manage patients with suspected metal hypersensitivity reactions, this review aims to analyze current evidence on hypersensitivity reactions to metallic implants in orthopedic surgery, endovascular surgery, obstetrics and gynecology, and dental surgery. Key words: Metal hypersensitivity. Metallic implants. ResumenEl empleo de metales dentro de la medicina ha ido aumentando de forma progresiva en las últimas décadas. Los pacientes se exponen a metales de diferentes formas desde fuentes externas, como instrumental quirúrgico como el presente en las hojas de acero de los bisturíes, hasta implantes metálicos. Como consecuencia de ello se está produciendo un interés creciente por la posibilidad de desarrollar reacciones de hipersensibilidad a metales presentes en los materiales y objetos implantados, tanto en forma de reacciones cutáneas como sistémicas. Las reacciones de hipersensibilidad a metales no son frecuentes, pero pueden desarrollarse, y por ello, requieren de un diagnóstico y tratamiento adecuado, especialmente en aquellos pacientes que desarrollen síntomas. No existe un consenso en el proceso diagnóstico ni en el tratamiento de estas reacciones en los pacientes con sospecha de alergia a metales. Esta revisión tiene por objeto actualizar la evidencia existente sobre las reacciones de hipersensibilidad a implantes metálicos en cirugía ortopédica, cirugía endovascular, cirugía obstétrica y ginecológica (OB-GYN) así como la dental. Palabras clave: Hipersensibilidad a metales. Implantes metálicos.

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Oral manifestations of gold allergy

Cited by 107 publications

References 17 publications

Update On Oral Lichen Planus: Etiopathogenesis and Management

Update On Oral Lichen Planus: Etiopathogenesis and Management

Oral Lichen Planus and Allergy to Dental Amalgam Restorations

Hypersensitivity Reactions to Implanted Metal Devices: Facts and Fictions

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