Oral manifestations and the role of the oral healthcare workers in COVID‐19

Spirito, Federica Di; Pelella, Sergio; Argentino, Salvatore; Sisalli, Laura; Sbordone, Ludovico

doi:10.1111/odi.13688

Cited by 33 publications

(22 citation statements)

References 10 publications

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“…7 Additionally, studies during the COVID-19 pandemic have demonstrated the importance of oral care in patients seeking hospital service due to the possible correlations between oral health status and overall clinical status and for the possibility of oral lesion onset before the respiratory condition. [7][8][9] Corroborating previous studies with similar populations 10 the inpatients analyzed in this study presented a higher prevalence of oral disorders, with dysphagia, xerostomia, candidiasis, and mucositis being the most frequent conditions. These alterations are frequently observed in patients undergoing oncologic therapy such as radiotherapy (RT) and chemotherapy (CT), especially in the head and neck region.…”

supporting

confidence: 77%

Evaluation of oral alterations in patients of a private hospital in the southern region of Brazil

Locatelli

Santos

Visioli

et al. 2021

Special Care in Dentistry

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Oral health impact the overall health of patients in hospital care because they patients are particularly vulnerable to oral infections and may present complications resulting from their medical condition. 1,2 Studies have demonstrated an association between oral cavity infections and systemic diseases as well as the worsening of these comorbidities due to imbalanced oral conditions. [1][2][3][4][5] The need for dental assessment in hospitals seems to present differences beyond the underlying disease and the treatment the patient is undergoing. The pattern of oral complications may be related to geographic heterogeneity between countries and within a country, as well as to the level of care complexity. 5,6 Thus, this study aimed to investigated the prevalence of the most common reasons for dental assessment among outpatients and inpatients at a private hospital in southern Brazil.The present study was approved by the Ethics and

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supporting

confidence: 77%

Evaluation of oral alterations in patients of a private hospital in the southern region of Brazil

Locatelli

Santos

Visioli

et al. 2021

Special Care in Dentistry

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show abstract

“…Such multi-system involvement characterizing COVID-19 may be attributable to the wide topographic distribution of the viral Angiotensin Converting Enzyme 2 (ACE2) binding receptor, mediating cell invasion, which has been detected in upper and lower respiratory apparatus; gastrointestinal tract, including oral epitheliocytes; exocrine glands, along with salivary ones; cardiovascular and genitourinary systems; skeletal muscles and skin [ 5 , 6 , 7 ]. Consistently, multiple case reports and series, as well as letters to the Editor and comments [ 8 , 9 , 10 , 11 ], have later described several lesions of the oral mucosa potentially ascribable to SARS-CoV-2 infection or observed in patients with COVID-19, clearly highlighting heterogeneous macroscopic features and uncertain prevalence.…”

Section: Introductionmentioning

confidence: 59%

“…A large body of evidence has described lesions of the oral mucosa, potentially ascribable to SARS-CoV-2 infection or observed in patients with COVID-19, clearly highlighting heterogeneous macroscopic features and uncertain prevalence [ 8 , 9 , 10 , 11 ]. Therefore, the present systematic review of systematic reviews aims, primarily, to point out the overall prevalence of cases diagnosed with oral lesions among adult SARS-CoV-2-positive subjects and to, secondarily, estimate the degree of association between oral lesions and SARS-CoV-2 infection [ 12 ] and grade, based on the reported frequency, the primary oral lesions, with related clinical presentations and microscopic features, in relation to COVID-19 forms [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Features and Degree of Association of Oral Lesions in COVID-19: A Systematic Review of Systematic Reviews

Spirito

Iandolo

Amato

et al. 2022

IJERPH

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Regardless of rapidly emerging findings on oral lesions described in adult SARS-CoV-2-positive subjects, the evidence level remains quite low and rather contrasting; therefore, the present systematic review of systematic reviews primarily aims to point out the overall prevalence of diagnosed cases. Secondary aims are to estimate the degree of association between oral lesions and SARS-CoV-2 infection and to grade, based on the reported frequency, the primary oral lesions, with related clinical presentations and microscopic features, in relation to COVID-19 forms. A study protocol compliant with the PRISMA statement was developed. Twelve studies were included, reporting highly heterogeneous and incomplete findings, thus precluding a meta-analysis. Further studies should be conducted to assess the overall prevalence of cases diagnosed with oral lesions among adult SARS-CoV-2-positive subjects, especially considering novel viral variants, and to determine their degree of association with SARS-CoV-2 infection and COVID-19 forms. Moreover, the reported findings noticed the need to evaluate the putative role both of SARS-CoV-2 in oral lesions genesis and of periodontitis and periodontal microbiome in COVID-19 worsening and re-activations. Deeper insights into oral lesions in adult SARS-CoV-2-positive subjects could enhance the comprehension of illness pathogenesis, natural history and clinical presentation, thus improving the preparedness of health professionals in the inter-disciplinary management of COVID-19.

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“…The hypothesized bi-directional relationship between periodontitis and peri-implantitis, on the one side, and hyperlipidemia, on the other side, may rely on the shared etiologic factors, comprising genetic susceptibility, smoking, stress, altered immune and inflammatory response, and on the common pathogenic pathways [1]. Specifically, periodontal pathogens may gain access to the systemic circulation, colonize atheromatous plaques [43], and, along with their toxins and the proinflammatory cytokines from inflamed periodontal tissues, determine the so-called "systemic inflammation", which is considered to be the key associating link between periodontitis and several systemic inflammatory and neoplastic diseases [1,8,[10][11][12][13][14]44,45]. Consequently, the causal treatment of such disorders may positively affect both periodontal conditions around teeth and implants, as well as the lipidemic status [17,19].…”

Section: Discussionmentioning

confidence: 99%

Periodontal and Peri-Implant Diseases and Systemically Administered Statins: A Systematic Review

et al. 2021

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Hyperlipidemia is a well-recognized risk factor for cardiovascular disease, which, in turn, acts as a contributory factor in periodontitis development. Periodontitis has been associated with benign tumors and cancers and withseveral disorders, including hyperlipidemia. Correspondingly, periodontal treatment may exert a positive effect on lipid metabolism, although opposite evidence has also been reported. As a counterpart, the therapy for hyperlipidemia, conventionally based on statins, has been proposed to positively affect periodontal conditions, mainly due to statin pleiotropic effects, reducing periodontal inflammation and promoting osseointegration. Therefore, the present systematic review aimed to evaluate, in subjects with untreated periodontitis and peri-implant disease (Population), the effect of routine systemically administered statins (Intervention), compared to non-statin use (Comparison), on periodontal parameters around natural teeth and implants (Outcome). Discordant results were found in periodontal parameters, and the current lack of such data related to peri-implant tissues and to alveolar bone loss highlights the need for further studies on the topic, potentially paving the way for a more comprehensive approach to periodontitis and peri-implantitis management. Indeed, the validation of the beneficial effect provided by systemically delivered statins on periodontal and peri-implant tissues may direct recall scheduling, predict response to therapy and, therefore, guide treatment strategies of periodontal and peri-implant treatments in statin users.

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Oral manifestations and the role of the oral healthcare workers in COVID‐19

Cited by 33 publications

References 10 publications

Evaluation of oral alterations in patients of a private hospital in the southern region of Brazil

Evaluation of oral alterations in patients of a private hospital in the southern region of Brazil

Prevalence, Features and Degree of Association of Oral Lesions in COVID-19: A Systematic Review of Systematic Reviews

Periodontal and Peri-Implant Diseases and Systemically Administered Statins: A Systematic Review

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