Oral manifestation of Covid-19 as an inaugural symptom?

Chaux-Bodard, Anne-Gaëlle; Deneuve, Sophie; Desoutter, Aline

doi:10.1051/mbcb/2020011

Cited by 148 publications

(169 citation statements)

References 2 publications

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“…The reported oral ulcer was preceded by macular erythema and pain (probably associated with vasculitis) in an adult female patient, who also developed a skin lesion. In this case, the ulcer healed after 10 days 7 . In our cases, the lesions resolved during treatment and days after the infection.…”

Section: Discussionsupporting

confidence: 57%

“…The oral mucosae lesions were referred to as viral enanthemas 6 . Chaux‐Bodard et al and Martín Carreras‐Presas et al reported ulcerative and vesiculobullous lesions in the oral cavity in patients confirmed and suspicious of new coronavirus disease 7,8 . The salivary gland and oral epithelium present the ACE2 receptor, a membranous protein used as a mechanism of attachment for SARS‐COV‐2, and due to this epithelial tropism, it is considered a route of viral latency and transmission 9,10 .…”

Section: Introductionmentioning

confidence: 99%

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Oral mucosal lesions in patients with SARS‐CoV‐2 infection. Report of four cases. Are they a true sign of COVID‐19 disease?

Tapia

Labrador

Guimarães

et al. 2020

Special Care in Dentistry

103

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Background Vesiculobullous and macular lesions in the oral mucosa have been reported in patients positive for SARS‐CoV‐2 infection. Nonetheless, the significance and physiopathology of oral manifestations have not been clearly established in the clinical progression or outcome of the infection. Aim To describe the clinico‐pathological oral mucosal lesions in four patients with confirmed SARS‐CoV‐2 infection. Methods and Results Four patients with COVID‐19 disease and confirmed by polymerase chain reaction (PCR) presented angina bullosa hemorragica‐like lesion, vascular disorder, and nonspecific stomatitis, one patient with histological analysis demonstrated perivascular reactive lymphocitic infliltrate, focal capillary thrombosis, and hemorrhage. According to the discrimination of other local and systemic conditions and the synchronous onset of oral and systemic symptoms, the diagnosis of oral lesions probably associated with COVID‐19 was established. Conclusion Infection with SARS‐CoV‐2 may result in oral manifestations with various clinical presentations, which presumably support the hypothesis of thrombi formation and vasculitis; nevertheless, these findings need more evidence and a long‐term follow up of patients to accurately establish the significance of the oral mucosa affection in the COVID‐19 disease.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Oral mucosal lesions in patients with SARS‐CoV‐2 infection. Report of four cases. Are they a true sign of COVID‐19 disease?

Tapia

Labrador

Guimarães

et al. 2020

Special Care in Dentistry

103

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“…In literature, several cases of oral manifestations apparently related to SARS-CoV-2 have been described [ 19 , 20 , 21 ]. The importance of good oral hygiene could be an interesting aspect to evaluate a hypothetical relationship between SARS-CoV-2 and oral manifestations.…”

Section: Introductionmentioning

confidence: 99%

“…Periodontopathic bacteria, involved in several process like inflammation, bacteraemia, pneumonia, are also present in the metagenome of positive SARS-CoV-2 patients [ 23 ]. Several authors described case reports of SARS-CoV-2-positive patients with oral manifestations potentially compatible with this type of coronavirus [ 19 , 20 , 21 ]. Moreover, a key factor in the damage of the respiratory system and other organs could be related to the distribution of ACE2 receptors in the human system [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 and Oral Manifestation: An Observational, Human Study

Sinjari

D’Ardes

Santilli

et al. 2020

JCM

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The correlation between SARS-CoV-2 and oral manifestations is still controversial. The aim of this observational study was to determine the oral manifestation of the hospitalized patients for COVID-19. A total of 20 patients met the inclusion criteria and gave their signed informed consent. A questionnaire of 32 questions regarding the oral and systemic health condition was administrated to these patients during the convalescence. A descriptive statistic was performed. Data were analysed through the use of χ2 test, to assess the statistical significance. A statistically significant increase of about 30% of reporting xerostomia during hospitalization was observed (p = 0.02). Meanwhile, a decrease of oral hygiene was observed during the hospitalization, even if a non-statistically significant difference was shown between the two study time points (before and after hospitalization). During the hospitalization period, 25% of patients reported impaired taste, 15% burning sensation, and 20% difficulty in swallowing. An interesting result was that among the systemic conditions, hypertension was observed in 39% of patients and mostly in female patients (62.5%). Further studies are necessary to better understand the symptoms of this new virus in order to faster detect its presence in humans. Probably, a multidisciplinary team following the COVID-19 patients could be of key importance in treating this disease.

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“…Entre los síntomas orales que se han descrito en los pacientes COVID-19, están la ageusia (Vaira et al, 2020), la hipogeusia y la disgeusia (Vinayachandran & Balasubramanian, 2020), Esto es de particular importancia porque, el receptor de la enzima convertidora de angiotensina 2, al que se une el SARS-CoV-2 para poder entrar en la célula huésped, se expresa altamente en las células epiteliales, especialmente en la lengua, en comparación con los tejidos orales o gingivales de la cavidad oral (Xu et al, 2020). Por otro lado, hasta mediados de junio de 2020 se han publicado solo cuatro reportes (Chaux-Bodard et al, 2020;Galván et al, 2020;Jimenez-Cauhe et al, 2020;Carreras-Presas et al, 2020) y además otro, que es el único que incluye el estudio histopatológico y que menciona un posible mecanismo etipatologénico (Soares et al, 2020). Todos esos reportes abordan una escasa casuística, lo que sugiere, por un lado, que algunas lesiones orales pudieran ser expresión clínica de la infección por SARS-CoV-2, y por otro, que los pacientes deban ser evaluados con un examen oral completo para diagnosticar adecuadamente la presencia posible de estas lesiones y relacionarlas con la COVID-19.…”

Section: Sr Editorunclassified

COVID-19 y manifestaciones orales

Cornejo-Ovalle

Espinoza-Santander

2020

Int. J. Odontostomat.

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Oral manifestation of Covid-19 as an inaugural symptom?

Cited by 148 publications

References 2 publications

Oral mucosal lesions in patients with SARS‐CoV‐2 infection. Report of four cases. Are they a true sign of COVID‐19 disease?

Oral mucosal lesions in patients with SARS‐CoV‐2 infection. Report of four cases. Are they a true sign of COVID‐19 disease?

SARS-CoV-2 and Oral Manifestation: An Observational, Human Study

COVID-19 y manifestaciones orales

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