Oral malodorous gases and oral microbiota: From halitosis to carcinogenesis

Tanda, Naoko; Hoshikawa, Yasushi; Ishida, Naoko; Sato, Takuichi; Takahashi, Nobuhiro; Hosokawa, Ryoichi; Koseki, Takeyoshi

doi:10.1016/j.job.2015.05.004

Cited by 4 publications

(2 citation statements)

References 51 publications

(59 reference statements)

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“… 34 35 36 It has also been reported that the bacteria responsible for malodor are mostly Fusobacterium nucleatum and Porphyromonas gingivalis . 37 38 39 There are two general ways for assessing malodor: organoleptic and instrumental technique. In organoleptic method, malodor is evaluated by the examiner's sense of smell.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Different Antimicrobial Agents on Malodor Prevention in Two-Stage Dental Implants: A Double-Blinded Randomized Clinical Trial

2022

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Objective Opening of a healing abutment in two-stage implant systems is usually followed by a bad smell. Previous studies have found that presence of bacteria in microleakages of the implant-abutment interface results in further malodor. However, studies focusing on preventive treatments for this issue are scarce. Therefore, the aim of this study is to evaluate the effectiveness of two antimicrobial agents on prevention of malodor followed by opening the healing abutments. Materials and Methods Current double-blinded randomized clinical trial was performed on 51 eligible patients who were referred for their exposure surgery. They were divided equally into three parallel groups. In two groups, either chlorhexidine or tetracycline was added to the internal surface of the fixtures before screwing the healing abutments. One group did not receive any intervention. Three to 4 weeks later malodor was scored by sniffing the healing abutments immediately after uncovering them (odorless = 0/odor = 1). The three groups were then compared regarding malodor scores. Results Our findings showed that malodor was more frequent in the control group (58.82%) in comparison with groups of intervention (17.65 and 23.53%). There was a statistically significant difference between malodor in patients in whom antimicrobial agents (chlorhexidine and tetracycline) were used in their implants and the control group (p-value = 0.023). However, malodor in the chlorhexidine group and tetracycline group did not show any significant difference (p-value = 1). Conclusion Based upon the data from this study, it appears that local antimicrobial agents including chlorhexidine and tetracycline result in less malodor production within the implant-abutment interface. Clinical Significance A specific type of malodor is commonly seen after opening the healing abutment of a two-stage dental implant. Not only this issue is noticed by the dentist, but also annoyed the patient. Using local antimicrobial agents in the fixtures is likely to be a simple, easily applicable solution that satisfies both patients and dentists, and eliminates the possibility of further inflammation.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Different Antimicrobial Agents on Malodor Prevention in Two-Stage Dental Implants: A Double-Blinded Randomized Clinical Trial

2022

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“…About 700 different microbial species cause a number of different infections and inflammation in the oral cavity (Kuramitsu et al 2007 ; Tsuzukibashi et al 2014 ). The most common microbial oral diseases are periodontal inflammation (Ke et al 2016 ) and halitosis (Tanda et al 2015 ). These diseases may be caused by various anaerobic bacteria such as Streptococcus mutans , Porphyromonas gingivalis , Prevotella intermedia , and Fusobacterium nucleatum (Zhen et al 2008 ; Patra et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis

Qiao

Wang

Xu³

et al. 2018

AMB Expr

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Porphyromonas gingivalis is a pathogenic Gram-negative anaerobic bacterium that colonizes the subgingival region of gums. These bacteria can invade periodontal tissues, form plaques, and produce volatile sulfur compounds (VSC) and volatile organic compounds (VOC). Egg yolk immunoglobulin (IgY) that was specifically produced in egg yolks after chickens were challenged with P. gingivalis could control and prevent oral diseases caused by P. gingivalis. The releases of P. gingivalis offensive metabolic odors in vitro and in vivo were determined using a Halimeter and GCMS. With IgY bacterial growth was inhibited, and the relative amounts of VOC and VSC were decreased. The scores for the oral health index and the levels of IL-6 and TNF-α are also decreased. All treatment groups showed significant anti-inflammatory effects, which strongly suggests that specifically IgY against P. gingivalis may be an effective treatment for the prevention and protection of periodontal inflammation and halitosis.

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Oral biosciences: The annual review 2015

Ohshima

2016

Journal of Oral Biosciences

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Oral malodorous gases and oral microbiota: From halitosis to carcinogenesis

Cited by 4 publications

References 51 publications

Effectiveness of Different Antimicrobial Agents on Malodor Prevention in Two-Stage Dental Implants: A Double-Blinded Randomized Clinical Trial

Effectiveness of Different Antimicrobial Agents on Malodor Prevention in Two-Stage Dental Implants: A Double-Blinded Randomized Clinical Trial

Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis

Oral biosciences: The annual review 2015

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