Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis

Qiao, Wu; Wang, Fang; Xu, Xiang; Wang, Shujun; Regenstein, Joe M.; Bao, Bin; Ma, Ming

doi:10.1186/s13568-018-0706-0

Cited by 4 publications

(2 citation statements)

References 53 publications

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“…There is evidence linking malodorous breath to certain species in the saliva microbiome (Takeshita et al, 2010). Moreover, recent research was able to connect certain pathogens such as Porphyromonas gingivalis and its volatile sulfur compound, 3-bromo-5-chloro-1-tosyl-1Hpyrrolo[2,3-b]pyridine, to malodorous breath (Qiao et al, 2018). Dental caries is a recurrent disease, which is associated with poor oral hygiene.…”

Section: Promising Areas Of Research In Bacterial Infection Volatilomementioning

confidence: 99%

Volatilomes of Bacterial Infections in Humans

Elmassry

Piechulla

2020

Front. Neurosci.

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Sense of smell in humans has the capacity to detect certain volatiles from bacterial infections. Our olfactory senses were used in ancient medicine to diagnose diseases in patients. As humans are considered holobionts, each person's unique odor consists of volatile organic compounds (VOCs, volatilome) produced not only by the humans themselves but also by their beneficial and pathogenic micro-habitants. In the past decade it has been well documented that microorganisms (fungi and bacteria) are able to emit a broad range of olfactory active VOCs [summarized in the mVOC database (http://bioinformatics.charite.de/mvoc/)]. During microbial infection, the equilibrium between the human and its microbiome is altered, followed by a change in the volatilome. For several decades, physicians have been trying to utilize these changes in smell composition to develop fast and efficient diagnostic tools, particularly because volatiles detection is non-invasive and non-destructive, which would be a breakthrough in many therapies. Within this review, we discuss bacterial infections including gastrointestinal, respiratory or lung, and blood infections, focusing on the pathogens and their known corresponding volatile biomarkers. Furthermore, we cover the potential role of the human microbiota and their volatilome in certain diseases such as neurodegenerative diseases. We also report on discrete mVOCs that affect humans.

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Section: Promising Areas Of Research In Bacterial Infection Volatilomementioning

confidence: 99%

Volatilomes of Bacterial Infections in Humans

Elmassry

Piechulla

2020

Front. Neurosci.

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“…One of the members of this species P. gingivalis is a Gram-negative anaerobic bacterium common in oral microbiota that can overcolonise the subgingival region resulting in a bad, putrid mouth odour. A number of studies used egg yolk immunoglobulin (IgY) produced in egg yolks after chickens were challenged 19 or immunised 20 with P. gingivalis that could control and prevent oral diseases caused by P. gingivalis as an effective treatment for halitosis. There are no benefits reported from any of the members of this genus; its many species are members of human or animal oral microbiota associated with oral pathogenesis or emerging pathogens like Porphyromonas levii commonly reported in cattle rumen and several veterinary clinical cases, including bovine interdigital necrobacillosis 21 .…”

Section: Discussionmentioning

confidence: 99%

Phytogenic supplement containing menthol, carvacrol and carvone ameliorates gut microbiota and production performance of commercial layers

Bajagai

Petranyi

et al. 2022

Sci Rep

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Consumer push towards open and free-range production systems makes biosecurity on farms challenging, leading to increased disease and animal welfare issues. Phytogenic products are increasingly becoming a viable alternative for the use of antibiotics in livestock production. Here we present a study of the effects of commercial phytogenic supplement containing menthol, carvacrol and carvone on intestinal microbiota of layer hens, microbial functional capacity, and intestinal morphology. A total of 40,000 pullets were randomly assigned to two sides of the experimental shed. Growth performance, mortality, egg production and egg quality parameters were recorded throughout the trial period (18–30 weeks of age). Microbial community was investigated using 16S amplicon sequencing and functional difference using metagenomic sequencing. Phytogen supplemented birds had lower mortality and number of dirty eggs, and their microbial communities showed reduced richness. Although phytogen showed the ability to control the range of poultry pathogens, its action was not restricted to pathogenic taxa, and it involved functional remodelling the intestinal community towards increased cofactor production, heterolactic fermentation and salvage and recycling of metabolites. The phytogen did not alter the antimicrobial resistance profile or the number of antibiotic resistance genes. The study indicates that phytogenic supplementation can mimic the action of antibiotics in altering the gut microbiota and be used as their alternative in industry-scale layer production.

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In Vivo and In Vitro Volatile Organic Compounds (VOCs) Analysis in Bacterial Diagnostics: Case Studies in Agriculture and Human Diseases

Elmassry

Farag

2020

Bacterial Volatile Compounds as Mediators of Airborne Interactions

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Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis

Cited by 4 publications

References 53 publications

Volatilomes of Bacterial Infections in Humans

Volatilomes of Bacterial Infections in Humans

Phytogenic supplement containing menthol, carvacrol and carvone ameliorates gut microbiota and production performance of commercial layers

In Vivo and In Vitro Volatile Organic Compounds (VOCs) Analysis in Bacterial Diagnostics: Case Studies in Agriculture and Human Diseases

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