Oral malignant melanoma in Japan

Tanaka, Nobuyuki; Amagasa, Teruo; Iwaki, Hiroshi; Shioda, Shigetoshi; Takeda, Masamune; Ohashi, Kennichi; Reck, Steven F.

doi:10.1016/0030-4220(94)90121-x

Cited by 88 publications

(43 citation statements)

References 33 publications

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“…In most cases, there is a male predominance in a ratio of 2.8:1. [4] The 1995 Westop Banff workshop endorsed to classify OMM separately from cutaneous lesions and to include terminologies such as melanoma in situ and invasive melanoma. [5] The criteria for the diagnosis of primary oral melanoma described by Greene et al are confirmation of oral mucosal melanoma, presence of junctional activity, and inability to identify any other primary site.…”

Section: Discussionmentioning

confidence: 99%

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Malignant melanoma of the mandibular gingiva

Aroquiadasse¹,

Malik²,

Ramesh³

et al. 2017

IJMDCR

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Malignant melanoma is a perilous tumor originating from melanocytes. Malignant melanoma of the oral cavity has a sporadic occurrence and accounts for about <1% of all oral malignancies. The tumor most commonly occurs in the palate and the maxillary gingiva in the oral cavity, and seldom involves the mandibular gingiva. In this article, we report a 41-year-old man with primary oral malignant melanoma, which presented as a pedunculated pigmented growth involving the mandibular ridge associated with the lower front teeth. Focus is laid on early identification and reporting of such cases. Appropriate knowledge coupled with a high index of clinical suspicion about melanotic lesions may help in early diagnosis of this rare pathology.

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Section: Discussionmentioning

confidence: 99%

“…The incidence of mucosal melanoma is believed to remain stable, unlike cutaneous melanoma. [4] The most important task after diagnosis is identifying if the lesion is a primary tumor or metastatic. The most common sites of occurrence of metastatic melanoma are the mandible, buccal mucosa, and tongue.…”

Section: Discussionmentioning

confidence: 99%

Malignant melanoma of the mandibular gingiva

Aroquiadasse¹,

Malik²,

Ramesh³

et al. 2017

IJMDCR

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“…An excisional biopsy with a 1 to 2 mm margin for small lesion or an incisional biopsy through the thickest or the most suspicious part of the tumor in case of large lesion is required. 8 Fine needle aspiration or exfoliative cytology of primary pigmented lesion is contraindicated. It has been suggested that cutting into malignant neoplasm during an incisional biopsy or other invasive procedure could result in accidental dissemination of malignant cells within the adjacent tissues or even in the blood or lymphatic stream, with the subsequent risk of local recurrences or regional or distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Surgical Decision Making in Oral Mucosal Melanoma with Lymphadenopathy: Review of Literature

Bakshi¹,

Mukherjee²,

Chauhan³

2014

International Journal of Head and Neck Surgery

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The oral mucosal melanoma (OMM) comprises less than 1% of all malignant melanomas. Most mucosal melanomas occur in occult site, which together with lack of early and specific signs contribute to late and poor diagnosis. Because of their rare ness, the knowledge about their pathogenesis and risk factors is insufficient, and also there are not well-established protocols for staging and treatment of mucosal melanomas with lympha denopathy. Surgery is the mainstay of treatment. Radiotherapy and other adjunctive therapies can provide better local control in some locations, but did not show improvement in survival. In this article, we present a case of 52yearold female with OMM (excision performed elsewhere) presenting with large left upper cervical swelling after 2 years postexcision. We will review the literature that help us in taking decision in the management of OMMs in light of following patient.

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“…Although MMs with characteristic melanin-pigmented tumor cells are easy to diagnose, amelanotic MMs (AMMs) are extremely difficult to diagnosis due to the absence of these cells (3,4). AMM can be divided into the following five types based on the varied clinical features observed: The pigmented nodular type, the non-pigmented nodular type, the pigmented macular type, the pigmented mixed type and the non-pigmented mixed type (5,6). The non-pigmented nodular type is an amelanotic tumor that lacks a radial growth phase, while the non-pigmented mixed type is an amelanotic nodular tumor that is surrounded by a radial growth phase.…”

Section: Introductionmentioning

confidence: 99%

A rare case of amelanotic malignant melanoma in the oral region: Clinical investigation and immunohistochemical study

et al. 2015

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Abstract. Amelanotic malignant melanoma (AMM) is rare in the oral region. The present study examined the clinical features of this tumor in an attempt to establish diagnostic criteria. The expression of three melanocytic differentiation markers, HMB-45, S-100 and Melan-A, was also measured in primary oral AMMs in order to determine whether the markers could be used to diagnose primary oral AMMs and to find out which marker was the most sensitive. It may be particularly difficult to correctly diagnose AMM that lacks a radial growth phase without immunohistochemical assistance. In the present study, mixtures of polygonal and spindle cells at different ratios were observed in the tumors with and without a radial growth phase. Immunohistochemistry was used to examine the HMB-45, S-100 and Melan-A expression in the formalin-fixed paraffin-embedded specimens of primary oral AMMs. Comparison of staining intensities (SIs) and labeling indices (LIs) of the markers was also performed. The immunostaining results revealed that the SI of Melan-A was significantly higher than that of S-100 (P= 0.0011). HMB-45, S-100 and Melan-A also exhibited high positive rates and LIs in AMMs and, therefore, may be good markers for the immunohistochemical diagnosis of primary oral AMMs. Furthermore, Melan-A may be a more sensitive marker than S-100 and HMB-45, as it has a higher SI.

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Oral malignant melanoma in Japan

Cited by 88 publications

References 33 publications

Malignant melanoma of the mandibular gingiva

Malignant melanoma of the mandibular gingiva

Surgical Decision Making in Oral Mucosal Melanoma with Lymphadenopathy: Review of Literature

A rare case of amelanotic malignant melanoma in the oral region: Clinical investigation and immunohistochemical study

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