Oral magnesium supplementation reduces the incidence of gastrointestinal complications following cardiac surgery: a randomized clinical trial

Moradian, Seyed Tayeb; Ghiasi, Mohammad Saeid; Mohamadpour, Alireza; Siavash, Yadollah

doi:10.1684/mrh.2017.0420

Cited by 14 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blood lymphocyte numbers showed the lowest values before parturition and then increased at parturition which is in line with previous study in cows [ 45 ], whereas stable numbers throughout the TP were reported by Eger et al, [ 7 ] and Cui et al, [ 27 ].…”

Section: Discussionsupporting

confidence: 91%

“…Activation of cellular proliferation is initiated by growth factors that increase glucose uptake and protein synthesis [ 23 ], since Mg is a key factor in both processes and in the activation of mammalian target of rapamycin (mTOR) complex [ 24 ]. Thus, Mg is undoubtedly involved, in cell signalling and proliferation, which confirms its immunomodulatory potential [ 25 – 27 ].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Blood leukocyte composition and function in periparturient ewes kept on different dietary magnesium supply

et al. 2020

View full text Add to dashboard Cite

Background Transition period (TP) is characterised by physiological and metabolic changes contributing to immunodysregulation. Since knowledge about this period in sheep is scarce, we analysed changes in selected immune variables during the TP in ewes and whether dietary magnesium (Mg) supplementation could modulate these immune variables. Pregnant ewes (2nd and 3rd lactation) were divided into a control group (CONT, n = 9) and a Mg group (MAG, n = 10) supplemented with Mg oxide resulting in a daily Mg intake of approximately 0.30 and 0.38% (MAG) of dry matter during ante- (a.p.) and post-partum (p.p.) periods, respectively. Blood samples were collected between days (d) 30 a.p. and d 30 p.p.. Whole blood neutrophil phagocytic activity, monocyte subset (classical cM, intermediate intM, non-classical ncM) composition and the proliferative capacity of lymphocytes were determined flow cytometrically. At d 14 a.p., all ewes were vaccinated against Mycobacterium avium subsp. paratuberculosis (MAP). Results Both groups showed a sharp increase in the total leukocyte counts (TLC) and neutrophil counts (P < 0.0001), at d 1 p.p., while, monocytes and their subpopulations displayed the highest values at d 30 p.p. (P ≤ 0.05). At d 1 p.p. the neutrophil phagocytic activity was higher (P < 0.05) in MAG ewes. Throughout the TP, the proliferative response of CD4+ cells was significantly higher in the MAG group (P < 0.05). Ewes in both groups responded with an increase in the TLC, neutrophil numbers (P ≤ 0.05) and ncM (P < 0.001) 24 h post vaccination, whereas monocytes and cM dropped in numbers (P ≤ 0.05). Numbers of intM only increased in MAG ewes (P < 0.05), whereas lymphocyte numbers decreased (P < 0.01). Mg supplementation did not affect the significant increase in MAP-specific antibodies at d 7 and 21 post vaccination. Total Mg and Ca serum levels did not show any differences between the two groups. Conclusion Whereas TP-associated fluctuations in blood leukocyte numbers are not influenced by Mg supplementation, neutrophil phagocytic activity, the proliferative capacity of CD4+ cells and the cellular response within 24 h after a vaccination are subject to modulation.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 98%

Blood leukocyte composition and function in periparturient ewes kept on different dietary magnesium supply

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The frequency of defecation in children receiving 30 mg/kg magnesium oxide of body weight per day, is effectively improved, and the stool consistency is significantly decreased at the fourth week ( Pickering et al, 2011 ). Recent research has further proven that oral magnesium supplementation (800 mg magnesium oxide daily) prevents the postoperative complications of cardiac surgery, including nausea, vomiting and constipation in patients from the admission to discharge from hospital ( Moradian et al, 2017 ). The data from a clinical trial including a total of 259 patients with gallbladder cancer, 701 patients with gallstones, and 851 population-based controls in Shanghai, China, have demonstrated that serum magnesium level is inversely related to gallbladder disease ( Lee et al, 2020 ).…”

Section: Therapeutic Application Of Magnesium In Other Diseasesmentioning

confidence: 99%

“… Digestive diseases Kim et al (2015) Korea Magnesium sulfate infusion Intravenous magnesium sulfate of 50 mg/kg over 10 min before the start of sedation Intravenous magnesium sulfate reduces analgesic requirements both during and after endoscopic submucosal dissection for gastric neoplasm without adverse effects. Moradian et al (2017) Iran Oral magnesium supplementation 800 mg magnesium oxide (2 tablets each of them containing 240 mg elemental magnesium) daily Magnesium supplementation improves less atrial fibrillation, nausea, vomiting, and constipation in patients undergoing cardiac surgery. Pickering G et al (2020) Japan Oral magnesium supplementation 30 mg/kg magnesium oxide of body weight per day Magnesium supplementation exhibits significant improvement in defecation frequency and decrease in stool consistency in young children with functional chronic constipation.…”

Section: Therapeutic Application Of Magnesium In Other Diseasesmentioning

confidence: 99%

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

Tang

Ding

Jiao

et al. 2020

European Journal of Pharmacology

100

View full text Add to dashboard Cite

Magnesium as an enzymatic activator is essential for various physiological functions such as cell cycle, metabolic regulation, muscle contraction, and vasomotor tone. A growing body of evidence supports that magnesium supplementation (mainly magnesium sulfate and magnesium oxide) prevents or treats various types of disorders or diseases related to respiratory system, reproductive system, nervous system, digestive system, and cardiovascular system as well as kidney injury, diabetes and cancer. The ongoing pandemic coronavirus disease 19 (COVID-19) characterized by respiratory tract symptoms with different degrees of important organ and tissue damages has attracted global attention. Particularly, effective drugs are still lacking in the COVID-19 therapy. In this review, we find and summarize the effectiveness of magnesium supplementation on the disorders or diseases, and provide a reference to the possibility of magnesium supplementation for supportive treatment in patients with COVID-19.

show abstract

“…Inhibition of N-methyl D-aspartate receptors such as magnesium and receivers leads to a painful stimuli-induced inhibition of central sensitivity of the environment [2].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Magnesium Sulfate in Reduction of Post Cardiac Surgery Arrhythmia, Agitation and Pain: A randomized controlled study

Hamed¹,

Farhan²

2018

Anesth Pain Res

View full text Add to dashboard Cite

Background: Arrhythmia, postoperative pain and agitation are a common complication after heart surgery and are a major source of morbidity and mortality. Aims: This study aimed to study the efficacy of magnesium sulfate (MgSO 4) for reduction of post cardiac surgery arrhythmia, postoperative pain and agitation. Setting and Design: This study design was a prospective randomized controlled double blinded clinical study. Patients and Methods: 140 adult patients that underwent elective cardiac surgery were randomized into 2 groups, Mg group (group magnesium), 70 patients received 30 mg.kg-1 MgSO 4 in 500 cc normal saline and in group C (control group), 70 patients received 500 cc normal saline alone.

show abstract

Oral magnesium supplementation reduces the incidence of gastrointestinal complications following cardiac surgery: a randomized clinical trial

Cited by 14 publications

References 0 publications

Blood leukocyte composition and function in periparturient ewes kept on different dietary magnesium supply

Blood leukocyte composition and function in periparturient ewes kept on different dietary magnesium supply

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

The Efficacy of Magnesium Sulfate in Reduction of Post Cardiac Surgery Arrhythmia, Agitation and Pain: A randomized controlled study

Contact Info

Product

Resources

About